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Source: RSC - Chem. Commun. latest articles
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Total 58 results found since Jan 2013.
Efficient siRNA-peptide conjugation for specific targeted delivery to tumor cells
Chem. Commun., 2017, Accepted Manuscript DOI: 10.1039/C6CC10287E, CommunicationAlbert Gandioso, Anna Massaguer, Nuria Villegas, Candida Salvans, Dani Sanchez, Isabelle Brun-Heath, Vicente Marchan, Modesto Orozco, Montserrat Terrazas Despite the broad applicability of the Huisgen cycloaddition reaction, the click functionalization of RNAs with peptides remains still a challenge. Here we describe a straightforward method for the click functionalization... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - February 13, 2017 Category: Chemistry Authors: Albert Gandioso Source Type: research
Intercalation-mediated Nucleic Acid Nanoparticles for siRNA Delivery
Chem. Commun., 2016, Accepted Manuscript DOI: 10.1039/C6CC06024B, CommunicationKejin Zhou, Petra Kos, Yunfeng Yan, Xiong Hu, Yi-Li Min, Karina Kinghorn, Jonathan Minnig, Jason B Miller, Daniel Siegwart Tremendous effort has been made to improve stability and delivery efficacy of small RNA therapeutics. However, nearly all current nano-encapsulation carriers utilize the critical balance between only two interacting parameters:... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - September 14, 2016 Category: Chemistry Authors: Kejin Zhou Source Type: research
One-step Gene Delivery into Cytoplasm in a Fusion-Dependent Manner Based on a New Membrane Fusogenic Lipid
Chem. Commun., 2016, Accepted ManuscriptDOI: 10.1039/C6CC01996J, CommunicationHongzhang Deng, Xuefei Zhao, Dongxuan He, Weisheng Guo, Keni Yang, Anjie Dong, Xing-Jie LiangA new type of membrane fusogenic lipid was prepared to delivery DNA or siRNA into the cytoplasm directly in a fusion-dependent manner in order to bypass the cellular endocytosis to...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - April 26, 2016 Category: Chemistry Authors: Hongzhang Deng Source Type: research
Multifunctional organic nanoparticles with aggregation-induced emission (AIE) characteristics for targeted photodynamic therapy and RNA interference therapy
We report the design of AIE fluorogen (AIEgen)-based multifunctional organic nanoparticles with surface siRNA decoration for targeted photodynamic therapy and RNA interference therapy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - January 14, 2016 Category: Chemistry Authors: Guorui Jin Source Type: research
Catalytic self-assembly of a DNA dendritic complex for efficient gene silencing
Chem. Commun., 2016, Advance ArticleDOI: 10.1039/C5CC06937H, CommunicationYifan Lv, Ruizi Peng, Yu Zhou, Xiaobing Zhang, Weihong TanA catalytic self-assembled DNA dendritic complex was herein reported for efficient and convenient siRNA-based gene silencing with low cytotoxicity.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - December 2, 2015 Category: Chemistry Authors: Yifan Lv Source Type: research
Construction of negatively charged and environment-sensitive nanomedicine for tumor-targeted efficient siRNA delivery
Chem. Commun., 2016, Advance ArticleDOI: 10.1039/C5CC09181K, CommunicationYong Wang, Hong Xiao, Jing Fang, Xingsu Yu, Zhenwei Su, Du Cheng, Xintao ShuaiA siRNA delivery system with pH and reduction dual-sensitivity was developed for efficient target gene silencing in cancer therapy.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - November 25, 2015 Category: Chemistry Authors: Yong Wang Source Type: research
Catalytic Self-assembly of DNA Dendritic Complex for Efficient Gene Silencing
Chem. Commun., 2015, Accepted ManuscriptDOI: 10.1039/C5CC06937H, CommunicationYifan Lv, Ruizi Peng, Yu Zhou, xiaobing Zhang, Weihong TanA catalytic self-assembled DNA dendritic complex was herein reported and used for siRNA-based gene silencing. This kind of one-pot DNA dendrimer can be conveniently prepared as needed, and it was...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - November 20, 2015 Category: Chemistry Authors: Yifan Lv Source Type: research
Construction of negatively charged and environment-sensitive nanomedicine for tumor-targeted efficient siRNA delivery
Chem. Commun., 2015, Accepted ManuscriptDOI: 10.1039/C5CC09181K, CommunicationDu Cheng, Yong Wang, Hong Xiao, Zhen Wei Su, Jing Fang, Xingsu Yu, Xintao ShuaiA novel siRNA delivery system based on triblock copolymer with pH and reduction dual-sensitivity was introduced. The polyplex has high delivery efficiency not depending on surface charge reversion in response...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - November 16, 2015 Category: Chemistry Authors: Du Cheng Source Type: research
Gold-Installed Biostable Nanocomplexes for Tumor-Targeted siRNA Delivery In Vivo
Chem. Commun., 2015, Accepted ManuscriptDOI: 10.1039/C5CC05639J, CommunicationRoun Heo, Hong Yeol Yoon, Hyewon Ko, Jung Min Shin, Jueun Jeon, Yee Soo Chae, Young Mo Kang, Dukjoon Kim, Doo Sung Lee, Jae Hyung ParkThe key issues, associated with nanocarriers for small interfering RNAs (siRNAs), are their poor stability and lack of tumor targetability in vivo. To address these needs, we developed gold-installed polyethyleneimine/siRNA...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - September 21, 2015 Category: Chemistry Authors: Roun Heo Source Type: research
Cationic Fluorescent Polymer Core-Shell Nanoparticles for Encapsulation, Delivery, and Non-Invasively Tracking Intracellular Release of siRNA
Chem. Commun., 2015, Accepted ManuscriptDOI: 10.1039/C4CC09685A, CommunicationJi-Cheng Yu, Sha Zhu, Pei-Jian Feng, Cheng-Gen Qian, Jun Huang, Min-Jie Sun, Qun-Dong ShenA multifunctional nanocarrier for encapsulation and delivery of short interfering RNA (siRNA) has been realized using cationic fluorescent polymer core-shell nanoparticles. The nanocarrier has good biocompatibility and high transfection efficiency...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - January 14, 2015 Category: Chemistry Authors: Ji-Cheng Yu Source Type: research
Regulated protonation of polyaspartamide derivatives bearing repeated aminoethylene side chains for efficient intracellular siRNA delivery with minimal cytotoxicity
Chem. Commun., 2015, Accepted ManuscriptDOI: 10.1039/C4CC09859E, CommunicationHui Gao, Hiroyasu Takemoto, Qixian Chen, Mitsuru Naito, Hirokuni Ucida, Xueying Liu, Kanjiro Miyata, Kazunori KataokaEffects of repeated number (RN) of aminoethylene (AE) units in polyaspartamide side chains were investigated for polyion complex (PIC)-based siRNA delivery. Reduction of apparent RN from 3 to 2 by...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - January 9, 2015 Category: Chemistry Authors: Hui Gao Source Type: research
Cellular activity of siRNA oligonucleotides containing synthetic isomorphic nucleoside surrogates
Chem. Commun., 2015, Advance ArticleDOI: 10.1039/C4CC08809C, CommunicationDongwon Shin, Peter Lonn, Steven F. Dowdy, Yitzhak TorSingly and multiply modified synthetic siRNA oligonucleotides, containing highly isomorphic surrogate nucleobases, show high interference activity in cell culture.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - December 15, 2014 Category: Chemistry Authors: Dongwon Shin Source Type: research
Synthetic fluorescent probes capable of selective recognition of 3prime or minute-overhanging nucleotides for siRNA delivery imaging
Chem. Commun., 2015, Advance ArticleDOI: 10.1039/C4CC08800J, CommunicationTakaya Sato, Yusuke Sato, Kenta Iwai, Shusuke Kuge, Seiichi Nishizawa, Norio TeramaePeptide nucleic acid (PNA)-thiazole orange (TO) conjugates are developed as fluorescent probes capable of selective recognition of 3[prime or minute]-overhanging nucleotides of siRNAs for an accurate analysis of the siRNA delivery process.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - December 9, 2014 Category: Chemistry Authors: Takaya Sato Source Type: research
Cellular activity of siRNA oligonucleotides containing synthetic isomorphic nucleoside surrogates
Chem. Commun., 2014, Accepted ManuscriptDOI: 10.1039/C4CC08809C, CommunicationDongwon Shin, Peter Lonn, Steven Dowdy, Yitzhak TorSingly and multiply modified synthetic siRNA oligonucleotides, containing isomorphic surrogate nucleobases, show high interference potency in cell culture, suggesting the highly isomorphic RNA alphabet, based on a thieno[3,4-d]-pyrimidine core, is...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - December 5, 2014 Category: Chemistry Authors: Dongwon Shin Source Type: research
Synthetic Fluorescent Probes Capable of Selective Recognition of 3'-Overhanging Nucleotides for siRNA Delivery Imaging
Chem. Commun., 2014, Accepted ManuscriptDOI: 10.1039/C4CC08800J, CommunicationTakaya Sato, Yusuke Sato, Kenta Iwai, Shusuke Kuge, Seiichi Nishizawa, Norio TeramaeSmall interferring RNAs (siRNAs) hold great potential as therapeutic agents due to their gene silencing abilities in a sequence-specific manner through an RNA interference (RNAi) process. The tools to analyze...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - November 29, 2014 Category: Chemistry Authors: Takaya Sato Source Type: research
