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Source: RSC - Chem. Commun. latest articles
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Total 58 results found since Jan 2013.
Directed arrangement of siRNA via polymerization-induced electrostatic self-assembly
Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/C9CC08858J, CommunicationLiangliang Shen, Yahui Li, Qunzan Lu, Xiaoliang Qi, Xuan Wu, Zaigang Zhou, Jianliang Shen Herein, polymerization-induced electrostatic self-assembly (PIESA) is conducted to mediate the self-assembly behavior of short interfering RNA (siRNA) for the first time. In PIESA, siRNA not only formed a simple electrostatic... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - January 17, 2020 Category: Chemistry Authors: Liangliang Shen Source Type: research
A bioreducible linear poly(small beta-amino ester) for siRNA delivery
, 2013, Accepted ManuscriptDOI: 10.1039/C3CC40718G, CommunicationKristen Lynn Kozielski, Stephany Yi Tzeng, Jordan J GreenDescribed here is the synthesis and characterization of a novel, bioreducible linear poly([small beta]-amino ester) designed to condense siRNA into nanoparticles and efficiently release it upon entering the cytoplasm. Delivery of...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - April 15, 2013 Category: Chemistry Authors: Kristen Lynn Kozielski Source Type: research
Intracellular buildup reaction of active siRNA species from short RNA fragments
Chem. Commun., 2013, Accepted ManuscriptDOI: 10.1039/C3CC47529H, CommunicationHideto Maruyama, Yuko Nakasima, Satoshi Shuto, Akira Matsuda, Yoshihiro Ito, Hiroshi AbeHere we report a new strategy for buildup reaction of active siRNA species from short RNA fragments in living cells, using a chemical ligation reaction. This strategy could decrease undesired...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - December 2, 2013 Category: Chemistry Authors: Hideto Maruyama Source Type: research
An intracellular buildup reaction of active siRNA species from short RNA fragments
Chem. Commun., 2014, Advance ArticleDOI: 10.1039/C3CC47529H, CommunicationHideto Maruyama, Yuko Nakashima, Satoshi Shuto, Akira Matsuda, Yoshihiro Ito, Hiroshi AbeAn intracellular buildup reaction of active siRNA species from short RNA fragments provided a potent RNAi effect without stimulation of immune response.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - December 24, 2013 Category: Chemistry Authors: Hideto Maruyama Source Type: research
Biocompatible, Chimeric Peptide-Condensed Supramolecular Nanoparticles for Tumor Cell-Specific siRNA Delivery and Gene Silencing
Chem. Commun., 2014, Accepted ManuscriptDOI: 10.1039/C4CC01061B, CommunicationHangxiang Wang, Wei Chen, Haiyang Xie, Xuyong Wei, Shengyong Yin, Lin Zhou, Xiao Xu, Shusen ZhengWith the increased potential of RNA interference (RNAi) as a therapeutic modality, there is broad interest in the development of biocompatible vehicles for efficient, cell-specific delivery of siRNA agents. To...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - May 12, 2014 Category: Chemistry Authors: Hangxiang Wang Source Type: research
Self-assembled DNA nanostructures prepared by rolling circle amplification for the delivery of siRNA conjugates
Chem. Commun., 2014, Advance ArticleDOI: 10.1039/C4CC03834G, CommunicationCheol Am Hong, Bora Jang, Eun Hye Jeong, Hansaem Jeong, Hyukjin LeeLarge-scale preparation of DNA nanostructures for siRNA delivery has been achieved by an isothermal enzymatic amplification process.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - June 26, 2014 Category: Chemistry Authors: Cheol Am Hong Source Type: research
Biological Stability and Activity of siRNA in Ionic Liquids
Chem. Commun., 2014, Accepted ManuscriptDOI: 10.1039/C4CC05086J, CommunicationRomiza Mazid, Upulie Divisekera, Wenjuan Yang, Vijayaraghavan Ranganathan, Doug MacFarlane, Christina Cortez-Jugo, Wenlong Cheng: Small interfering RNA (siRNA) is extremely promising as a therapeutic due to its efficient and specific gene silencing in both in vitro and in vivo studies. However, siRNAs are...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - September 5, 2014 Category: Chemistry Authors: Romiza Mazid Source Type: research
Cellular activity of siRNA oligonucleotides containing synthetic isomorphic nucleoside surrogates
Chem. Commun., 2014, Accepted ManuscriptDOI: 10.1039/C4CC08809C, CommunicationDongwon Shin, Peter Lonn, Steven Dowdy, Yitzhak TorSingly and multiply modified synthetic siRNA oligonucleotides, containing isomorphic surrogate nucleobases, show high interference potency in cell culture, suggesting the highly isomorphic RNA alphabet, based on a thieno[3,4-d]-pyrimidine core, is...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - December 5, 2014 Category: Chemistry Authors: Dongwon Shin Source Type: research
Synthetic fluorescent probes capable of selective recognition of 3prime or minute-overhanging nucleotides for siRNA delivery imaging
Chem. Commun., 2015, Advance ArticleDOI: 10.1039/C4CC08800J, CommunicationTakaya Sato, Yusuke Sato, Kenta Iwai, Shusuke Kuge, Seiichi Nishizawa, Norio TeramaePeptide nucleic acid (PNA)-thiazole orange (TO) conjugates are developed as fluorescent probes capable of selective recognition of 3[prime or minute]-overhanging nucleotides of siRNAs for an accurate analysis of the siRNA delivery process.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - December 9, 2014 Category: Chemistry Authors: Takaya Sato Source Type: research
Cellular activity of siRNA oligonucleotides containing synthetic isomorphic nucleoside surrogates
Chem. Commun., 2015, Advance ArticleDOI: 10.1039/C4CC08809C, CommunicationDongwon Shin, Peter Lonn, Steven F. Dowdy, Yitzhak TorSingly and multiply modified synthetic siRNA oligonucleotides, containing highly isomorphic surrogate nucleobases, show high interference activity in cell culture.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - December 15, 2014 Category: Chemistry Authors: Dongwon Shin Source Type: research
Regulated protonation of polyaspartamide derivatives bearing repeated aminoethylene side chains for efficient intracellular siRNA delivery with minimal cytotoxicity
Chem. Commun., 2015, Accepted ManuscriptDOI: 10.1039/C4CC09859E, CommunicationHui Gao, Hiroyasu Takemoto, Qixian Chen, Mitsuru Naito, Hirokuni Ucida, Xueying Liu, Kanjiro Miyata, Kazunori KataokaEffects of repeated number (RN) of aminoethylene (AE) units in polyaspartamide side chains were investigated for polyion complex (PIC)-based siRNA delivery. Reduction of apparent RN from 3 to 2 by...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - January 9, 2015 Category: Chemistry Authors: Hui Gao Source Type: research
Cationic Fluorescent Polymer Core-Shell Nanoparticles for Encapsulation, Delivery, and Non-Invasively Tracking Intracellular Release of siRNA
Chem. Commun., 2015, Accepted ManuscriptDOI: 10.1039/C4CC09685A, CommunicationJi-Cheng Yu, Sha Zhu, Pei-Jian Feng, Cheng-Gen Qian, Jun Huang, Min-Jie Sun, Qun-Dong ShenA multifunctional nanocarrier for encapsulation and delivery of short interfering RNA (siRNA) has been realized using cationic fluorescent polymer core-shell nanoparticles. The nanocarrier has good biocompatibility and high transfection efficiency...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - January 14, 2015 Category: Chemistry Authors: Ji-Cheng Yu Source Type: research
Gold-Installed Biostable Nanocomplexes for Tumor-Targeted siRNA Delivery In Vivo
Chem. Commun., 2015, Accepted ManuscriptDOI: 10.1039/C5CC05639J, CommunicationRoun Heo, Hong Yeol Yoon, Hyewon Ko, Jung Min Shin, Jueun Jeon, Yee Soo Chae, Young Mo Kang, Dukjoon Kim, Doo Sung Lee, Jae Hyung ParkThe key issues, associated with nanocarriers for small interfering RNAs (siRNAs), are their poor stability and lack of tumor targetability in vivo. To address these needs, we developed gold-installed polyethyleneimine/siRNA...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - September 21, 2015 Category: Chemistry Authors: Roun Heo Source Type: research
Construction of negatively charged and environment-sensitive nanomedicine for tumor-targeted efficient siRNA delivery
Chem. Commun., 2015, Accepted ManuscriptDOI: 10.1039/C5CC09181K, CommunicationDu Cheng, Yong Wang, Hong Xiao, Zhen Wei Su, Jing Fang, Xingsu Yu, Xintao ShuaiA novel siRNA delivery system based on triblock copolymer with pH and reduction dual-sensitivity was introduced. The polyplex has high delivery efficiency not depending on surface charge reversion in response...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - November 16, 2015 Category: Chemistry Authors: Du Cheng Source Type: research
