Cellular activity of siRNA oligonucleotides containing synthetic isomorphic nucleoside surrogates

Chem. Commun., 2014, Accepted ManuscriptDOI: 10.1039/C4CC08809C, CommunicationDongwon Shin, Peter Lonn, Steven Dowdy, Yitzhak TorSingly and multiply modified synthetic siRNA oligonucleotides, containing isomorphic surrogate nucleobases, show high interference potency in cell culture, suggesting the highly isomorphic RNA alphabet, based on a thieno[3,4-d]-pyrimidine core, is...The content of this RSS Feed (c) The Royal Society of Chemistry

http://feeds.rsc.org/~r/rss/CC/~3/y-RUpZLPbDY/C4CC08809C

Source: RSC - Chem. Commun. latest articles - December 5, 2014 Category: Chemistry Authors: Dongwon Shin Source Type: research

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