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Source: RSC - Chem. Commun. latest articles
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Total 58 results found since Jan 2013.
Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex
Chem. Commun., 2023, Accepted Manuscript DOI: 10.1039/D3CC01143G, CommunicationDhrubajyoti Datta, Christopher Theile, June Qin, Kelly Wassarman , Karyn Schmidt, Tim Racie, Rachel Sigel, Yongfeng Jiang, Maja M. Janas, Martin Egli, Muthiah Manoharan To ensure specificity of small interfering RNAs (siRNAs), the antisense strand must be selected by the RNA induced silencing complex (RISC). We have previously demonstrated that a 5 ʹ-morpholino-modified nucleotide at... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - April 10, 2023 Category: Chemistry Authors: Dhrubajyoti Datta Source Type: research
Reactive oxygen species - responsive RNA interference
Chem. Commun., 2022, Accepted Manuscript DOI: 10.1039/D2CC00651K, CommunicationJennifer R ühle, Insa Klemt, Tatiana O. Abakumova, Olga Sergeeva, Polina Vetosheva, Timofei S. Zatsepin, Andriy Mokhir Due to oxidative instability, arylboronic acids are not compatible with solid phase synthesis of nucleic acids. We solved this problem and, based on these findings, developed siRNA prodrugs, activated in... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - March 8, 2022 Category: Chemistry Authors: Jennifer R ühle Source Type: research
A biodegradable amphiphilic poly(aminoester) dendrimer for safe and effective siRNA delivery
Chem. Commun., 2022, Accepted Manuscript DOI: 10.1039/D1CC06655B, CommunicationChi Ma, Dandan Zhu, Wenyi Lin, Ying Li, Yuanzheng Huang, Huiling Zhu, Mengyun Ye, Yang Wang, Ling Peng, Xiaoxuan Liu Small interfering RNA (siRNA)-based therapeutics represent a novel and compelling drug modality, provided that safe and competent vectors are available for their delivery. Here, we report a biodegradable amphiphilic poly(aminoester)... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - January 16, 2022 Category: Chemistry Authors: Chi Ma Source Type: research
A functional and self-assembling octyl-phosphonium-tagged esculetin as an effective siRNA delivery agent
Chem. Commun., 2021, Advance Article DOI: 10.1039/D1CC03497A, CommunicationAltab Shaikh, Praveen Kumar Neeli, Gajalakshmi Singuru, Sravya Panangipalli, Rajkumar Banerjee, Sridhar Reddy Maddi, Rajamannar Thennati, Surendar Reddy Bathula, Srigiridhar Kotamraju Herein, we describe the self-assembling ability of an amphiphilic phosphonium cationic lipid to form nanoparticles and deliver MnSOD siRNA into MDA-MB-231 cells. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - November 11, 2021 Category: Chemistry Authors: Altab Shaikh Source Type: research
Delivery of siRNA by tailored cell-penetrating urea-based foldamers
Chem. Commun., 2021, Accepted Manuscript DOI: 10.1039/D0CC06285E, CommunicationM égane Bornerie, Anaïs Brion, Gilles Guichard, Antoine Kichler, Céline Douat Cell-penetrating foldamers (CPFs) have recently shown promises as efficient and safe nucleic acid delivery systems. However applications of CPFs to siRNA transport remain scarce. Here, we report helical CPFs tailored... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - December 21, 2020 Category: Chemistry Authors: M égane Bornerie Source Type: research
Dual-targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells
Chem. Commun., 2020, Advance Article DOI: 10.1039/D0CC01848A, CommunicationTaehyung Kim, Ha Na Hyun, Roun Heo, Keonwook Nam, Kyungjik Yang, Young Min Kim, Yoon Suk Lee, Jae Yoon An, Jae Hyung Park, Ki Young Choi, Young Hoon Roh A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed. The Dual-PSNP showed significantly enhanced cancer-specific intracellular delivery, gene regulation efficacy, and apoptosis-mediated cytotoxicity through additive receptor-mediated interactions of the two ligands. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this ...
Source: RSC - Chem. Commun. latest articles - May 29, 2020 Category: Chemistry Authors: Taehyung Kim Source Type: research
Dual targeting RNA nanoparticles for efficient delivery of polymeric siRNA to cancer cells
Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/D0CC01848A, CommunicationTaehyung Kim, Hana Hyun, Roun Heo, Keonwook Nam, Kyungjik Yang, Young Min Kim, Yoon Suk Lee, Jae Yoon An, Jae Hyung Park, KI YOUNG CHOI, Young Hoon Roh A new dual-targeting polymeric siRNA nanoparticle (Dual-PSNP) was developed via multiple processes; rolling circle transcription, condensation, electrostatic deposition, and click chemistry. The Dual-PSNP showed significantly improved cancer specific intracellular delivery,... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - April 25, 2020 Category: Chemistry Authors: Taehyung Kim Source Type: research
Highly Efficient Photocontrolled Targeted Delivery of siRNA by a Cyclodextrin-Based Supramolecular Nanoassembly
In this study, we fabricated a binary supramolecular nanoassembly composed of α-cyclodextrin-modified hyaluronic acid and an azobenzene-modified diphenylalanine derivative with a positively charged imidazole group.This nanoassembly can bind with siRNA... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - February 29, 2020 Category: Chemistry Authors: Feng-Qing Li Source Type: research
Directed arrangement of siRNA via polymerization-induced electrostatic self-assembly
Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/C9CC08858J, CommunicationLiangliang Shen, Yahui Li, Qunzan Lu, Xiaoliang Qi, Xuan Wu, Zaigang Zhou, Jianliang Shen Herein, polymerization-induced electrostatic self-assembly (PIESA) is conducted to mediate the self-assembly behavior of short interfering RNA (siRNA) for the first time. In PIESA, siRNA not only formed a simple electrostatic... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - January 17, 2020 Category: Chemistry Authors: Liangliang Shen Source Type: research
Intracellular build-up RNAi with single-strand circular RNAs as siRNA precursors
Chem. Commun., 2020, Advance Article DOI: 10.1039/C9CC04872C, CommunicationYasuaki Kimura, Zhaoma Shu, Mika Ito, Naoko Abe, Kosuke Nakamoto, Fumiaki Tomoike, Satoshi Shuto, Yoshihiro Ito, Hiroshi Abe We herein report a new approach for RNA interference, so-called “build-up RNAi” approach, where single-strand circular RNAs with a photocleavable unit or disulfide moiety were used as siRNA precursors. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - December 12, 2019 Category: Chemistry Authors: Yasuaki Kimura Source Type: research
Intracellular Build-up RNAi with Single-Strand Circular RNAs as siRNA Precursors
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC04872C, CommunicationYasuaki Kimura, Zhaoma Shu, Mika Ito, Naoko Abe, Kosuke Nakamoto, Fumiaki Tomoike, Satoshi Shuto, Yoshihiro Ito, Hiroshi Abe We herein report a new approach for RNA interference, so-called “build-up RNAi” approach, where single-strand circular RNAs with a photocleavable unit or disulfide moiety were used as siRNA precursors. The... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - December 2, 2019 Category: Chemistry Authors: Yasuaki Kimura Source Type: research
Phthalocyanine-based Mesoporous Organosilica Nanoparticles: NIR photodynamic efficiency and siRNA photochemical internalization
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC05703J, CommunicationG ülçin Ekineker, Christophe Nguyen, Sumeyra Bayir, sofia dominguez-gil, Umit Isci, Morgane Daurat, Anastasia Godefroy, Laurence Raehm, Clarence Charnay, Erwan Oliviero, Vefa Ahsen, Magali Gary-Bobo, Jean-Olivier Durand, Fabienne Dumoulin Mesoporous Organosilica Nanoparticles (PHT-PMO) have been prepared from an octa-triethoxysilylated Zn phthalocyanine precursor. These PHT-PMO nanoparticles had no dark toxicity but high phototoxicity when irradiated at 650 nm, and remarkable... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - September 4, 2019 Category: Chemistry Authors: G ülçin Ekineker Source Type: research
Correction: 4 ′-Guanidinium-modified siRNA: a molecular tool to control RNAi activity through RISC priming and selective antisense strand loading
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Ganesh N. Nawale, Saeed Bahadorikhalili, Pallabi Sengupta, Sandeep Kadekar, Subhrangsu Chatterjee, Oommen P. Varghese To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - August 7, 2019 Category: Chemistry Authors: Ganesh N. Nawale Source Type: research
4 ′-Guanidinium-modified siRNA: A molecular tool to control RNAi activity through RISC priming and selective antisense strand loading
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Ganesh N. Nawale, Saeed Bahadorikhalili, Pallabi Sengupta, Sandeep Kadekar, Subhrangsu Chatterjee, Oommen P. Varghese We designed novel 4 ′-C-guanidinocarbohydrazidomethyl-5-methyl uridine (GMU) modified small interfering RNA (siRNA) and evaluated their biophysical and biochemical properties. Incorporation of GMU units significantly increased thermodynamic stability as well as the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - July 5, 2019 Category: Chemistry Authors: Ganesh N. Nawale Source Type: research
