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Source: RSC - Chem. Commun. latest articles
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Total 58 results found since Jan 2013.
Efficient delivery of siRNAs by a photothermal approach using plant flavonoid-inspired gold nanoshells
Chem. Commun., 2014, Advance ArticleDOI: 10.1039/C4CC07155G, CommunicationEun Hye Jeong, Ji Hyun Ryu, Hansaem Jeong, Bora Jang, Ho Yeon Lee, Seonki Hong, Haeshin Lee, Hyukjin LeePlant flavonoid-inspired polymer gold nanoshell (PGN) formation and NIR laser triggered siRNA delivery using PGN-siRNA conjugates.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - September 19, 2014 Category: Chemistry Authors: Eun Hye Jeong Source Type: research
Biological Stability and Activity of siRNA in Ionic Liquids
Chem. Commun., 2014, Accepted ManuscriptDOI: 10.1039/C4CC05086J, CommunicationRomiza Mazid, Upulie Divisekera, Wenjuan Yang, Vijayaraghavan Ranganathan, Doug MacFarlane, Christina Cortez-Jugo, Wenlong Cheng: Small interfering RNA (siRNA) is extremely promising as a therapeutic due to its efficient and specific gene silencing in both in vitro and in vivo studies. However, siRNAs are...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - September 5, 2014 Category: Chemistry Authors: Romiza Mazid Source Type: research
Enzymatic size control of RNA particles using complementary rolling circle transcription (cRCT) method for efficient siRNA production
Chem. Commun., 2014, Advance ArticleDOI: 10.1039/C4CC04969A, CommunicationDaehoon Han, Yongkuk Park, Hyangsu Nam, Jong Bum LeeA novel method to generate RNA particles was developed and the size of particles can be rationally controlled by adjusting the concentration of RNA polymerase.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - August 21, 2014 Category: Chemistry Authors: Daehoon Han Source Type: research
Enzymatic size control of RNA Particles with complementary rolling circle transcription (cRCT) for efficient siRNA production
Chem. Commun., 2014, Accepted ManuscriptDOI: 10.1039/C4CC04969A, CommunicationJong Bum Lee, Daehoon Han, Yongkuk Park, Hyangsu NamA novel fabrication method for RNA particles (RPs) was developed based on enzymatic polymerization, and the size of the RPs was controlled intentionally by adjusting the RNA polymerase concentration for...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - August 8, 2014 Category: Chemistry Authors: Jong Bum Lee Source Type: research
Self-assembled DNA nanostructures prepared by rolling circle amplification for the delivery of siRNA conjugates
Chem. Commun., 2014, Advance ArticleDOI: 10.1039/C4CC03834G, CommunicationCheol Am Hong, Bora Jang, Eun Hye Jeong, Hansaem Jeong, Hyukjin LeeLarge-scale preparation of DNA nanostructures for siRNA delivery has been achieved by an isothermal enzymatic amplification process.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - June 26, 2014 Category: Chemistry Authors: Cheol Am Hong Source Type: research
Self-assembled DNA Nanostructures by Rolling Circle Amplification for the Delivery of siRNA Conjugates
Chem. Commun., 2014, Accepted ManuscriptDOI: 10.1039/C4CC03834G, CommunicationCheol Am Hong, Bora Jang, Eun Hye Jeong, Han Sem Jung, Hyukjin LeeInspired by the isothermal enzymatic process of rolling circle amplification (RCA) of DNA strands, we have developed a system to achieve more than a 200-fold increase in the synthesis of...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - June 17, 2014 Category: Chemistry Authors: Cheol Am Hong Source Type: research
Biocompatible, Chimeric Peptide-Condensed Supramolecular Nanoparticles for Tumor Cell-Specific siRNA Delivery and Gene Silencing
Chem. Commun., 2014, Accepted ManuscriptDOI: 10.1039/C4CC01061B, CommunicationHangxiang Wang, Wei Chen, Haiyang Xie, Xuyong Wei, Shengyong Yin, Lin Zhou, Xiao Xu, Shusen ZhengWith the increased potential of RNA interference (RNAi) as a therapeutic modality, there is broad interest in the development of biocompatible vehicles for efficient, cell-specific delivery of siRNA agents. To...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - May 12, 2014 Category: Chemistry Authors: Hangxiang Wang Source Type: research
Multivalent Comb-Type Aptamer-siRNA Conjugates for Efficient and Selective Intracellular Delivery
In this study, a simple, efficient, and selective intracellular delivery strategy for RNA therapeutics into target cancer cells was designed using direct complementary base pairing between chemically conjugated multimeric antisense...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - May 8, 2014 Category: Chemistry Authors: HYUNDONG YOO Source Type: research
An intracellular buildup reaction of active siRNA species from short RNA fragments
Chem. Commun., 2014, Advance ArticleDOI: 10.1039/C3CC47529H, CommunicationHideto Maruyama, Yuko Nakashima, Satoshi Shuto, Akira Matsuda, Yoshihiro Ito, Hiroshi AbeAn intracellular buildup reaction of active siRNA species from short RNA fragments provided a potent RNAi effect without stimulation of immune response.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - December 24, 2013 Category: Chemistry Authors: Hideto Maruyama Source Type: research
Intracellular buildup reaction of active siRNA species from short RNA fragments
Chem. Commun., 2013, Accepted ManuscriptDOI: 10.1039/C3CC47529H, CommunicationHideto Maruyama, Yuko Nakasima, Satoshi Shuto, Akira Matsuda, Yoshihiro Ito, Hiroshi AbeHere we report a new strategy for buildup reaction of active siRNA species from short RNA fragments in living cells, using a chemical ligation reaction. This strategy could decrease undesired...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - December 2, 2013 Category: Chemistry Authors: Hideto Maruyama Source Type: research
A bioreducible linear poly(small beta-amino ester) for siRNA delivery
, 2013, Accepted ManuscriptDOI: 10.1039/C3CC40718G, CommunicationKristen Lynn Kozielski, Stephany Yi Tzeng, Jordan J GreenDescribed here is the synthesis and characterization of a novel, bioreducible linear poly([small beta]-amino ester) designed to condense siRNA into nanoparticles and efficiently release it upon entering the cytoplasm. Delivery of...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - April 15, 2013 Category: Chemistry Authors: Kristen Lynn Kozielski Source Type: research
Switchable delivery of small interfering RNA using a negatively charged pH-responsive polyethylenimine-based polyelectrolyte complex
Chem. Commun., 2013, Advance ArticleDOI: 10.1039/C3CC00134B, CommunicationS.-Ja. Tseng, Yi-Fang Zeng, Yu-Fan Deng, Pan-Chyr Yang, Je-Ruei Liu, Ivan M. KempsonA siRNA delivery system was developed in order to allow tumor acidosis-triggered release with low cytotoxicity and reversible functionality.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - February 24, 2013 Category: Chemistry Authors: S.-Ja. Tseng Source Type: research
Switchable delivery of small interfering RNA using a negatively-charged pH-responsive polyethylenimine-based polyelectrolyte complex
, 2013, Accepted ManuscriptDOI: 10.1039/C3CC00134B, CommunicationS.-Ja Tseng, Yi-Fang Zeng, Yu-Fan Deng, Pan-Chyr Yang, Je-Ruei Liu, Ivan M KempsonA small interfering RNA (siRNA)-loaded polyelectrolyte constructed with branched polyethylenimine (bPEI) and copolymer, consisting of polyethylene glycol (PEG), histidine (His), and glutamic acid (Glu) was developed in order to provide...The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - February 15, 2013 Category: Chemistry Authors: S.-Ja Tseng Source Type: research
