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Source: RSC - Chem. Commun. latest articles
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Total 58 results found since Jan 2013.
Selective RNA Interference and Gene Silencing Using Reactive Oxygen Species-responsive Lipid Nanoparticles
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC04517A, CommunicationChunjing Liang, Jin Chang, Ying Jiang, Ji Liu, Lanqun Mao, Ming Wang Lipid-complexed small interfering RNA (siRNA) nanoparticles are promising gene regulation materials present excellent genetic but little cellular selectivity. Herein, we report a chemical strategy to enhance the gene silencing selectivity... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - June 13, 2019 Category: Chemistry Authors: Chunjing Liang Source Type: research
Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating foldamers for efficient siRNA delivery
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC02203A, CommunicationTakashi Misawa, Nobumichi Ohoka, Makoto Oba, Hiroko Yamashita, Masakazu Tanaka, Mikihiko Naito, Yosuke Demizu We designed and synthesized a set of cell-penetrating foldamers (CPFs) composed of the common amino acids Leu, Arg, and Gly, as well as helicogenic amino acid 2-aminoisobutyric acid. The findings... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - June 3, 2019 Category: Chemistry Authors: Takashi Misawa Source Type: research
5 ′-Morpholino modification of the sense strand of an siRNA makes it a more effective passenger
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC00977A, CommunicationMuthiah Manoharan, Pawan Kumar, Rubina G. Parmar, Christopher R. Brown, Jennifer L. S. Willoughby, Donald Foster, Ramesh I Babu, Sally Schofield, Vasant Jadhav, Klaus Charisse, Jayaprakash K Nair, Kallanthottathil G Rajeev, Martin Maier, Martin Egli The 5 ’-monophosphate group plays an important role in strand selection during gene silencing mediated by small-interfering RNA. We show that blocking of 5′ phosphorylation of the sense strand by introducing... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - April 1, 2019 Category: Chemistry Authors: Muthiah Manoharan Source Type: research
DNA Tetrahedron-Based Nanogels for siRNA Delivery and Gene Silencing
Chem. Commun., 2019, Accepted Manuscript DOI: 10.1039/C9CC00175A, CommunicationHan Xue, Fei Ding, Jiao Zhang, Yuanyuan Guo, Xihui Gao, Jing Feng, Xinyuan Zhu, Chuan Zhang DNA tetrahedrons are employed as building blocks to construct a novel DNA-based nanogel for intracellular siRNA delivery. With compact architecture that embeds functional siRNAs inside, the self-assembled nanogel can efficiently... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - March 1, 2019 Category: Chemistry Authors: Han Xue Source Type: research
A DR4 capturer with AKT siRNA for the synergetic enhancement of death receptor-mediated apoptosis
Chem. Commun., 2018, Advance Article DOI: 10.1039/C8CC06796A, CommunicationWei Pan, Shaohua Gong, Yanhua Li, Huiwen Zhang, Na Li, Bo Tang A DR4 capturer with AKT siRNA was developed for the synergetic enhancement of death receptor-mediated apoptosis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - November 15, 2018 Category: Chemistry Authors: Wei Pan Source Type: research
A DR4 capturer with AKT siRNA for synergetic enhancement of death receptor-mediated apoptosis
Chem. Commun., 2018, Accepted Manuscript DOI: 10.1039/C8CC06796A, CommunicationWei Pan, Shaohua Gong, Yanhua Li, Huiwen Zhang, Na Li, Bo Tang A graphene-based nanocarrier modified with death receptor 4 (DR4) antibody and AKT siRNA has been developed, which can synergistically strengthen the death receptor-mediated apoptosis and enhance the cancer therapeutic effect... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - November 6, 2018 Category: Chemistry Authors: Wei Pan Source Type: research
A novel design of a polynuclear co-delivery system for safe and efficient cancer therapy
Chem. Commun., 2018, Advance Article DOI: 10.1039/C8CC03720E, CommunicationLei Xing, Jia-Liang Zhang, Tian-jiao Zhou, Yu-Jing He, Peng-Fei Cui, Jia-Hui Gong, Minjie Sun, Jin-Jian Lu, Zhangjian Huang, Liang Jin, Hu-Lin Jiang A polynuclear nanoparticle fabricated through a sequential hydrophobic and electrostatic interaction mechanism can circumvent the contradictory problem of siRNA binding capacity and toxicities of cationic vectors. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - July 20, 2018 Category: Chemistry Authors: Lei Xing Source Type: research
Redox-triggered intracellular siRNA delivery
Chem. Commun., 2018, Accepted Manuscript DOI: 10.1039/C8CC01376D, CommunicationNecibe Basaran Mutlu Agardan, Can Sarisozen, Vladimir Torchilin Stimuli-responsive nanopreparations are able to provide drug release in response to various physiological stimuli including redox potential. Gene silencing using small interfering RNA (siRNA) is a promising strategy for the... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - May 29, 2018 Category: Chemistry Authors: Necibe Basaran Mutlu Agardan Source Type: research
MTH1-Targeted Nanosystem for Enhanced PDT via Improving Cellular Sensitivity to Reactive Oxygen Species
Chem. Commun., 2018, Accepted Manuscript DOI: 10.1039/C8CC01841C, CommunicationHuanhuan Fan, Lili Zhang, Xiaoxiao Hu, Zilong Zhao, Huarong Bai, Xiaoyi Fu, Guobei Yan, Li-Hui Liang, Xiaobing Zhang, Weihong Tan Herein, we developed a strategy to attack cancer cell defense system against reactive oxygen species to improve photodynamic therapy efficacy with a Ce6@MSN@MTH1 siRNA nanosystem, which was demonstrated to improve... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - April 4, 2018 Category: Chemistry Authors: Huanhuan Fan Source Type: research
DNA nanoclew templated spherical nucleic acids for siRNA delivery
Chem. Commun., 2018, Advance Article DOI: 10.1039/C7CC09257A, CommunicationWeimin Ruan, Meng Zheng, Yang An, Yuanyuan Liu, David B. Lovejoy, Mingcong Hao, Yan Zou, Albert Lee, Shu Yang, Yiqing Lu, Marco Morsch, Roger Chung, Bingyang Shi A superior biocompatible spherical nucleic acid (SNA) conjugate was fabricated by grafting siRNA onto the surface of a core composed of a spherical DNA nanostructure that we have termed DNA nanoclew (DC). To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - March 23, 2018 Category: Chemistry Authors: Weimin Ruan Source Type: research
DNA nanoclew templated spherical nucleic acid for siRNA delivery
Chem. Commun., 2018, Accepted Manuscript DOI: 10.1039/C7CC09257A, CommunicationWeimin Ruan, Meng Zheng, Yang An, Yuanyuan Liu, David Lovejoy, Mingcong Hao, Yan Zou, Albert Lee, Shu Yang, Yiqing Lu, Marco Morsch, Roger Chung, Bingyang Shi A superior biocompatible spherical nucleic acid (SNA) conjugate was fabricated by grafting siRNA onto the surface of a core composed of a spherical DNA nanostucture we have termed a DNA... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - March 14, 2018 Category: Chemistry Authors: Weimin Ruan Source Type: research
A black phosphorus nanosheet-based siRNA delivery system for synergistic photothermal and gene therapy
Chem. Commun., 2018, Advance Article DOI: 10.1039/C8CC00931G, CommunicationHuimeng Wang, Lin Zhong, Yang Liu, Xin Xu, Chao Xing, Min Wang, Shu-Meng Bai, Chun-Hua Lu, Huang-Hao Yang A new siRNA delivery platform based on black phosphorus nanosheets is constructed which shows excellent therapy efficiency for tumors. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - March 12, 2018 Category: Chemistry Authors: Huimeng Wang Source Type: research
Black Phosphorus Nanosheets-Based siRNA Delivery System for Synergistic Photothermal and Gene Therapy
Chem. Commun., 2018, Accepted Manuscript DOI: 10.1039/C8CC00931G, CommunicationHuimeng Wang, Lin Zhong, Yang Liu, Xin Xu, Chao Xing, Min Wang, Shumeng Bai, Chun-Hua Lu, Huanghao Yang Gene therapy with small interfering RNA (siRNA) has been proved to be the promising technology to treat various diseases by hampering the production of target proteins. However, developing a delivery... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - March 2, 2018 Category: Chemistry Authors: Huimeng Wang Source Type: research
A lipid-based cell penetrating nano-assembly for RNAi-mediated anti-angiogenic cancer therapy
Chem. Commun., 2018, Advance Article DOI: 10.1039/C7CC08517F, CommunicationPoulami Majumder, Sukanya Bhunia, Arabinda Chaudhuri A tissue infiltrating peptide amphiphile-decorated nano-assembly induces significant mouse tumor growth inhibitionvia substantial tumor infiltration of encapsulated anti-angiogenic siRNA. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - January 23, 2018 Category: Chemistry Authors: Poulami Majumder Source Type: research
Efficient siRNA-peptide conjugation for specific targeted delivery into tumor cells
Chem. Commun., 2017, Advance Article DOI: 10.1039/C6CC10287E, CommunicationAlbert Gandioso, Anna Massaguer, Nuria Villegas, Candida Salvans, Dani Sanchez, Isabelle Brun-Heath, Vicente Marchan, Modesto Orozco, Montserrat Terrazas Efficient click siRNA-peptide conjugation for targeted delivery into tumor cells. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - February 20, 2017 Category: Chemistry Authors: Albert Gandioso Source Type: research
