Filtered By:
Drug: Dexamethasone

This page shows you your search results in order of date. This is page number 2.

Order by Relevance | Date

Total 197 results found since Jan 2013.

Mouse mesoderm-specific transcript inhibits adipogenic differentiation and induces trans-differentiation into hepatocyte-like cells in 3T3-L1 preadiocytes
BMC Res Notes. 2022 May 10;15(1):164. doi: 10.1186/s13104-022-06051-x.ABSTRACTOBJECTIVE: The mesoderm-specific transcript (Mest) is an imprinted gene that is transcribed from the paternal allele. It is a marker of adipose tissue expansion; however, it is uncertain whether Mest expression promotes or suppresses adipogenic differentiation. To elucidate the effects of Mest expression on adipogenic differentiation, we transfected an expression vector or siRNA for mouse Mest into 3T3-L1 mouse preadipocyte cell line.RESULTS: In differentiated 3T3-L1 adipocytes, Mest overexpression decreased lipid accumulation. Conversely, gene s...
Source: Cell Research - May 10, 2022 Category: Cytology Authors: Yoshito Kadota Takashige Kawakami Masao Sato Shinya Suzuki Source Type: research

Effect of miR-381-3p/FGF7 axis on the osteogenic differentiation of bone marrow mesenchymal stem cells through MEK/ERK signaling pathway
Tissue Cell. 2022 Apr 1;76:101791. doi: 10.1016/j.tice.2022.101791. Online ahead of print.ABSTRACTAlthough microRNAs (miRNAs) exert an important role in the osteogenesis of mesenchymal stem cells (MSCs), the effect of miR-381-3p on the osteogenic differentiation in MBD‑MSCs is still unclear. The BMMSCs from patients with MBD (MBD‑MSC) or normal participants (Normal‑MSC) were isolated and induced to differentiation with dexamethasone. BMMSCs were transfected with miR-381-3p mimic, miR-381-3p inhibitor, and FGF7 siRNA to regulate the expression of miR-381-3p or FGF7. The direct binding between miR-381-3p and FGF7 was p...
Source: Tissue and Cell - April 15, 2022 Category: Cytology Authors: Ling Qiu Jiao Cai Nan Zhang Lei Ma Fang-Yi Fan Xiao-Ming Li Source Type: research

Glucocorticoid receptor modulates myeloid-derived suppressor cell function via mitochondrial metabolism in immune thrombocytopenia
In conclusion, our study indicated that impaired aerobic metabolism in MDSCs participates in the pathogenesis of glucocorticoid resistance in ITP and that intact control of MDSC metabolism by GR contributes to the homeostatic regulation of immunosuppressive cell function.PMID:35414712 | DOI:10.1038/s41423-022-00859-0
Source: Cellular and Molecular Immunology - April 13, 2022 Category: Molecular Biology Authors: Yu Hou Jie Xie Shuwen Wang Daqi Li Lingjun Wang Haoyi Wang Xiaofei Ni Shaoqiu Leng Guosheng Li Ming Hou Jun Peng Source Type: research

Serum/glucocorticoid ‐regulated kinase 1‐targeted transient receptor potential oxalate subtype 1 regulates bladder smooth muscle cell proliferation due to bladder outlet obstruction in mice via activated T cell nuclear factor transcription factor 2
In this study, SGK1 targeted TRPV1 to regulate the proliferation of MBSMCs mediated by BOO in mice through NFAT2 and then affected the process of b ladder remodeling after BOO. This finding may provide a strategy for BOO drug target screening.
Source: IUBMB Life - February 21, 2022 Category: Research Authors: Jiangshu He, Jin Yang, Lin Chen, Pinglin He, Xun Liu, Kai Wang, Taotao Dong, Jia Li, Xudong Ma, Amend Bastian, Stenzl Arnulf Tags: RESEARCH COMMUNICATION Source Type: research

SGK1 ‐targeted TRPV1 regulates bladder smooth muscle cell proliferation due to BOO in mice via NFAT2
ConclusionIn this study, SGK1 targeted TRPV1 to regulate the proliferation of MBSMCs mediated by BOO in mice through NFAT2 and then affected the process of bladder remodeling after BOO. This finding may provide a strategy for BOO drug target screening.This article is protected by copyright. All rights reserved.
Source: IUBMB Life - February 12, 2022 Category: Research Authors: Jiangshu He, Jin Yang, Lin Chen, Pinglin He, Xun Liu, Kai Wang, Taotao Dong, Jia Li, Xudong Ma, Amend Bastian, Stenzl Arnulf Tags: RESEARCH COMMUNICATION Source Type: research