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Activation of CpG-ODN-Induced TLR9 Signaling Inhibited by Interleukin-37 in U937 Human Macrophages
CONCLUSION: IL-37 inhibits CpG-ODN-mediated inflammatory responses through regulation of a TRAF6-NF-κB pathway in human macrophages.PMID:34672136 | PMC:PMC8542467 | DOI:10.3349/ymj.2021.62.11.1023
Source: Yonsei Medical Journal - October 21, 2021 Category: Universities & Medical Training Authors: Seong-Kyu Kim Jung-Yoon Choe Ki-Yeun Park Source Type: research

Oxygen and Steroids Affect the Regulatory Role of Natriuretic Peptide Receptor-C on Surfactant Secretion by Type II Cells
Am J Physiol Lung Cell Mol Physiol. 2021 Oct 20. doi: 10.1152/ajplung.00300.2021. Online ahead of print.ABSTRACTAtrial natriuretic peptide (ANP) and its receptors Natriuretic peptide receptor (NPR)-A and NRP-C are all highly expressed in alveolar epithelial type II cells (AEC2s) in the late gestation ovine fetal lung and are dramatically decreased postnatally. However, of all the components, NPR-C stimulation inhibits ANP-mediated surfactant secretion. Since alveolar oxygen increases dramatically after birth, and steroids are administered to mothers antenatally to enhance surfactant lung maturity, we investigated the effec...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - October 20, 2021 Category: Cytology Authors: Rita M Ryan Manjeet K Paintlia Danforth A Newton Demetri D Spyropoulos Matthew W Kemp Alan Hall Jobe John E Baatz Source Type: research