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Drug: Aspirin
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Total 42 results found since Jan 2013.
DDIT4 Downregulation by siRNA Approach Increases the Activity of Proteins Regulating Fatty Acid Metabolism upon Aspirin Treatment in Human Breast Cancer Cells
Curr Issues Mol Biol. 2023 May 28;45(6):4665-4674. doi: 10.3390/cimb45060296.ABSTRACTRepositioning of aspirin for a more effective breast cancer (BC) treatment requires identification of predictive biomarkers. However, the molecular mechanism underlying the anticancer activity of aspirin remains fully undefined. Cancer cells enhance de novo fatty acid (FA) synthesis and FA oxidation to maintain a malignant phenotype, and the mechanistic target of rapamycin (mTORC1) is required for lipogenesis. We, therefore, aimed to test if the expression of mTORC1 suppressor DNA damage-inducible transcript (DDIT4) affects the activity of...
Source: Current Issues in Molecular Biology - June 27, 2023 Category: Molecular Biology Authors: Aist ė Savukaitytė Agn ė Bartnykaitė Justina Bekampyt ė Rasa Ugenskien ė Elona Juozaityt ė Source Type: research
Salicylic acid directly binds to ribosomal protein S3 and suppresses CDK4 expression in colorectal cancer cells
Biochem Biophys Res Commun. 2022 Aug 31;628:110-115. doi: 10.1016/j.bbrc.2022.08.082. Online ahead of print.ABSTRACTColorectal cancer is a significant cause of morbidity and represents a serious public health issue in many countries. The development of a breakthrough preventive method for colorectal cancer is urgently needed. Aspirin has recently been attracting attention as a cancer preventive drug, and its inhibitory effects on the development of various cancers have been reported in several large prospective studies. However, the underlying molecular mechanisms have not yet been elucidated in detail. In the present stud...
Source: Biochemical and Biophysical Research communications - September 9, 2022 Category: Biochemistry Authors: Ayaka Imai Mano Horinaka Yuichi Aono Yosuke Iizumi Hideki Takakura Hisako Ono Shusuke Yasuda Keiko Taniguchi Emi Nishimoto Hideki Ishikawa Michihiro Mutoh Toshiyuki Sakai Source Type: research
Aspirin blocks AMPK/SIRT3-mediated glycolysis to inhibit NSCLC cell proliferation
Eur J Pharmacol. 2022 Aug 15:175208. doi: 10.1016/j.ejphar.2022.175208. Online ahead of print.ABSTRACTNon-small cell lung cancer (NSCLC) has the highest incidence and mortality in the world. Aspirin has been reported to promote apoptosis, inhibit proliferation, stemness, angiogenesis, cancer-associated inflammation and migration in NSCLC. But the effect of aspirin on aerobic glycolysis in NSCLC is less reported. In the present study, we investigated whether aspirin blocked aerobic glycolysis of NSCLC cell to inhibit proliferation. Our results showed that aspirin inhibited viability, PCNA expression, ability of colony forma...
Source: European Journal of Pharmacology - August 18, 2022 Category: Drugs & Pharmacology Authors: Guanghui Ren Yan Ma Xingjie Wang Zhaodi Zheng Guorong Li Source Type: research
Aspirin-induced long non-coding RNA suppresses colon cancer growth
CONCLUSIONS: lncRNA NEAT1 and LOC152578 are involved in the inhibition of tumor cell growth and metastasis by aspirin. The results of these analyses will help us further understand the mechanism of action of aspirin and the roles of lncRNAs in the prevention and treatment of colon cancer.PMID:35116527 | PMC:PMC8798653 | DOI:10.21037/tcr-20-2248
Source: Cancer Control - February 4, 2022 Category: Cancer & Oncology Authors: Mingwei Chen Lili Wu Huajie Zhan Tonghua Liu Yan He Source Type: research
siRNA Knockdown of REDD1 Facilitates Aspirin-Mediated Dephosphorylation of mTORC1 Target 4E-BP1 in MDA-MB-468 Human Breast Cancer Cell Line
Source: Cancer Management and Research - February 4, 2021 Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
PGC1 β Regulates Breast Tumor Growth and Metastasis by SREBP1-Mediated HKDC1 Expression
Conclusions: PGC1β regulates breast cancer tumor growth and metastasis by SREBP1-mediated HKDC1 expression. This provides a novel therapeutic strategy through targeting the PGC1β/HKDC1 signaling pathway for breast cancer treatment.
Introduction
Breast cancer is a very common cancer with significant premature mortality in women. Around 12% of women in USA will have chance to be diagnosed with breast cancer during their lifetimes (1, 2). The development of breast cancer is regulated by many factors, and even as average survival rates have increased significantly as a result of many advanced treatments...
Source: Frontiers in Oncology - April 16, 2019 Category: Cancer & Oncology Source Type: research
Non-steroidal anti-inflammatory drugs increase MRP4 expression in an endometriotic epithelial cell line in a PPARa dependent manner.
CONCLUSIONS: MRP4 expression was increased in cells treated with NSAIDs and the nuclear receptor PPARa is involved. Elevated PGE2 levels in cell supernatants correlate with its increased transport by MRP4 after NSAID treatment. More importantly, we provide evidence that in endometriotic epithelial cells aspirin and non-aspirin NSAIDs treatments alter gene expression.
PMID: 30556891 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - December 18, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
