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Drug: Aspirin
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Total 42 results found since Jan 2013.
DDIT4 Downregulation by siRNA Approach Increases the Activity of Proteins Regulating Fatty Acid Metabolism upon Aspirin Treatment in Human Breast Cancer Cells
Curr Issues Mol Biol. 2023 May 28;45(6):4665-4674. doi: 10.3390/cimb45060296.ABSTRACTRepositioning of aspirin for a more effective breast cancer (BC) treatment requires identification of predictive biomarkers. However, the molecular mechanism underlying the anticancer activity of aspirin remains fully undefined. Cancer cells enhance de novo fatty acid (FA) synthesis and FA oxidation to maintain a malignant phenotype, and the mechanistic target of rapamycin (mTORC1) is required for lipogenesis. We, therefore, aimed to test if the expression of mTORC1 suppressor DNA damage-inducible transcript (DDIT4) affects the activity of...
Source: Current Issues in Molecular Biology - June 27, 2023 Category: Molecular Biology Authors: Aist ė Savukaitytė Agn ė Bartnykaitė Justina Bekampyt ė Rasa Ugenskien ė Elona Juozaityt ė Source Type: research
