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Drug: Metformin
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Total 134 results found since Jan 2013.
Cancers, Vol. 13, Pages 739: Metformin Reduces Histone H3K4me3 at the Promoter Regions of Positive Cell Cycle Regulatory Genes in Lung Cancer Cells
This study aimed at understanding the effect of metformin on histone H3 methylation, DNA methylation, and chromatin accessibility in lung cancer cells. Metformin significantly reduced H3K4me3 level at the promoters of positive cell cycle regulatory genes such as CCNB2, CDK1, CDK6, and E2F8. Eighty-eight genes involved in cell cycle showed reduced H3K4me3 levels in response to metformin, and 27% of them showed mRNA downregulation. Metformin suppressed the expression of H3K4 methyltransferases MLL1, MLL2, and WDR82. The siRNA-mediated knockdown of MLL2 significantly downregulated global H3K4me3 level and inhibited lung cance...
Source: Cancers - February 10, 2021 Category: Cancer & Oncology Authors: Dongho Kim Yujin Kim Bo Bin Lee Eun Yoon Cho Joungho Han Young Mog Shim Duk-Hwan Kim Tags: Article Source Type: research
Suppression of Antiapoptotic Bcl-2 Expression in Human Bladder Tumor Cells Exposed to Hypoxic Environment is Regulated by Caveolin-1-dependent AMPK Activity
CONCLUSIONS: We suggest a new finding for the first time that AMPK activation can regulate Hif-1α induction as well as Hif-1α-induced Cav-1 expression, and the inhibitory effect of anti-apoptotic pathway on the exposure of RT4 cells to hypoxic environment is due to Cav-1-dependent AMPK activity.PMID:33752282 | DOI:10.5213/inj.2040444.222
Source: International Neurourology Journal - March 23, 2021 Category: Urology & Nephrology Authors: Tae Jin Cho Da-Hyun Lee Bo-Hwa Choi Helen K Shinn Chang-Shin Park Source Type: research
Dapagliflozin alleviates cardiac fibrosis through suppressing EndMT and fibroblast activation via AMPK α/TGF-β/Smad signalling in type 2 diabetic rats
This study aimed to evaluate the effect of SGLT2 inhibitor dapagliflozin (DAPA) on DCM especially for cardiac fibrosis and explore the underlying mechanism. In vivo, the model of type 2 diabetic rats was built with high-fat feeding and streptozotocin injection. Untreated diabetic rats showed cardiac dysfunction, increased myocardial fibrosis and EndMT, which was attenuated after treatment with DAPA and metformin. In vitro, HUVECs and primary cardiac fibroblasts were treated with DAPA and exposed to high glucose (HG). HG-induced EndMT in HUVECs and collagen secretion of fibroblasts were markedly inhibited by DAPA. Up-regula...
Source: J Cell Mol Med - June 25, 2021 Category: Molecular Biology Authors: Jingjing Tian Mingjun Zhang Mengying Suo Dian Liu Xuyang Wang Ming Liu Jinyu Pan Tao Jin Fengshuang An Source Type: research
Activated AMPK by metformin protects against fibroblast proliferation during pulmonary fibrosis by suppressing FOXM1
Pharmacol Res. 2021 Aug 24:105844. doi: 10.1016/j.phrs.2021.105844. Online ahead of print.ABSTRACTPulmonary fibrosis (PF) is a progressive and devastating lung disease of unknown etiology, excessive fibroblast proliferation serves as a key event to promote PF. Transcription factor forkhead box M1 (FOXM1) is not only a well-known proto-oncogene, but also an essential driver of cell proliferation. Recently, 5'-AMP-activated protein kinase (AMPK) is reported to reduce the incidence of PF. However, it remains elusive whether have an underlying relationship between AMPK and FOXM1 in fibroblast proliferation-mediated PF. Here, t...
Source: Cell Research - August 27, 2021 Category: Cytology Authors: Xuan Gu Yong-Yue Han Chong-Yang Yang Hui-Min Ji Yue-Jiao Lan Yu-Qian Bi Cheng Zheng Jiao Qu Ming-Han Cheng Jian Gao Source Type: research
Metformin alleviates the calcification of aortic valve interstitial cells through activating the PI3K/AKT pathway in an AMPK dependent way
CONCLUSIONS: This study, for the first time, demonstrates that metformin can inhibit AVICs in vitro calcification by activating the PI3K/AKT signaling pathway; this suggests that metformin may provide a potential target for the treatment of CAVD. And the PI3K/AKT signaling pathway emerges as an important regulatory axis in the pathological mechanism of CAVD.PMID:34895136 | DOI:10.1186/s10020-021-00416-x
Source: Molecular Medicine - December 13, 2021 Category: Molecular Biology Authors: Qiao En Huang Zeping Wang Yuetang Wang Xu Wang Wei Source Type: research
Acute Administration of Metformin Protects Against Neuronal Apoptosis Induced by Cerebral Ischemia-Reperfusion Injury via Regulation of the AMPK/CREB/BDNF Pathway
Metformin is a first-line anti-diabetic agent with a powerful hypoglycemic effect. Several studies have reported that metformin can improve the prognosis of stroke patients and that this effect is independent of its hypoglycemic effect; however, the specific mechanism remains unclear. In this research, we explored the effect and specific mechanism of metformin in cerebral ischemia-reperfusion (I/R) injury by constructing a transient middle cerebral artery occlusion model in vivo and a glucose and oxygen deprivation/reoxygenation (OGD/R) model in vitro. The results of the in vivo experiments showed that acute treatment with...
Source: Frontiers in Pharmacology - April 1, 2022 Category: Drugs & Pharmacology Source Type: research
Metformin Regulates TET2 Expression to Inhibit Endometrial Carcinoma Proliferation: A New Mechanism
ConclusionsTET2 may play an important role in EC development and may be a prognostic marker. Moreover, TET2 may be involved in a novel mechanism by which metformin inhibits EC cell proliferation.
Source: Frontiers in Oncology - April 11, 2022 Category: Cancer & Oncology Source Type: research
