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Specialty: Biochemistry
Drug: Acetylcysteine

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Total 20 results found since Jan 2013.

TCF12 regulates exosome release from epirubicin-treated CAFs to promote ER+ breast cancer cell chemoresistance
In this study, we showed that epirubicin (EPI) treatment triggered ROS which initiated autophagy in CAFs, TCF12 inhibited autophagy flux and further promoted exosome secretion. Inhibition of EPI-induced reactive oxygen species (ROS) production with N-acetyl-L-cysteine (NAC) or suppression of autophagic initiation with short interfering RNA (siRNA) against ATG5 blunted exosome release from CAFs. Furthermore, exosome secreted from EPI-treated CAFs not only prevented ROS accumulation in CAFs but also upregulated the CXCR4 and c-Myc protein levels in recipient ER+ breast cancer cells, thus promoting EPI resistance of tumor cel...
Source: Biochimica et Biophysica Acta - May 3, 2023 Category: Biochemistry Authors: Yuxiang Qiu Xing Wang Yan Sun Yan-E Du Guobing Yin Haojun Luo Siyang Wen Lei Lang Manran Liu Xi Tang Source Type: research

Increased mitochondrial fission induces NLRP3/cGAS-STING mediated pro-inflammatory pathways and apoptosis in UVB-irradiated immortalized human keratinocyte HaCaT cells
Arch Biochem Biophys. 2023 Mar 5;738:109558. doi: 10.1016/j.abb.2023.109558. Online ahead of print.ABSTRACTUltraviolet B (UVB) irradiation causes skin inflammation and apoptosis. Mitochondria are highly dynamic and undergo constant fusion and fission that are essential for maintaining physiological functions of cells. Although dysfunction of mitochondria has been implicated in skin damages, little is known about the roles of mitochondrial dynamics in these processes. UVB irradiation increases abnormal mitochondrial content but decreases mitochondrial volume in immortalized human keratinocyte HaCaT cells. UVB irradiation re...
Source: Archives of Biochemistry and Biophysics - March 6, 2023 Category: Biochemistry Authors: Can Li Yuying Zhu Weiwei Liu Toshihiko Hayashi Wendie Xiang Sijun He Kazunori Mizuno Shunji Hattori Hitomi Fujisaki Takashi Ikejima Source Type: research

The role of the voltage-gated potassium channel, Kv2.1 in prostate cancer cell migration
BMB Rep. 2021 Jan 7:5184. Online ahead of print.ABSTRACTVoltage-gated potassium (Kv) channels are involved in many important cellular functions and play pivotal roles in cancer progression. The expression level of Kv2.1 was observed to be higher in the highly metastatic prostate cancer cells (PC-3), specifically in their membrane, than in immortalized prostate cells (WPMY-1 cells) and comparatively less metastatic prostate cancer cells (LNCaP and DU145 cells). However, Kv2.1 expression was significantly decreased when the cells were treated with anti-oxidants, such as N-acetylcysteine or ascorbic acid, implying that the hi...
Source: BMB Reports - January 7, 2021 Category: Biochemistry Authors: Hyun Woo Park Min Seok Song Hun Ju Sim Pan Dong Ryu So Yeong Lee Source Type: research

The role of the voltage-gated potassium channel, Kv2.1 in prostate cancer cell migration.
Abstract Voltage-gated potassium (Kv) channels are involved in many important cellular functions and play pivotal roles in cancer progression. The expression level of Kv2.1 was observed to be higher in the highly metastatic prostate cancer cells (PC-3), specifically in their membrane, than in immortalized prostate cells (WPMY-1 cells) and comparatively less metastatic prostate cancer cells (LNCaP and DU145 cells). However, Kv2.1 expression was significantly decreased when the cells were treated with anti-oxidants, such as N-acetylcysteine or ascorbic acid, implying that the highly expressed Kv2.1 could detect reac...
Source: BMB Reports - January 7, 2021 Category: Biochemistry Authors: Park HW, Song MS, Sim HJ, Ryu PD, Lee SY Tags: BMB Rep Source Type: research

Arctigenin induces necroptosis through mitochondrial dysfunction with CCN1 upregulation in prostate cancer cells under lactic acidosis.
Abstract Arctigenin, a mitochondrial complex I inhibitor, has been identified as a potential anti-tumor agent, but the involved mechanism still remains elusive. Herein, we studied the underlying mechanism(s) of action of arctigenin on acidity-tolerant prostate cancer PC-3AcT cells in the lactic acid-containing medium. At concentration showing no toxicity on normal prostate epithelial RWPE-1 and HPrEC cells, arctigenin alone or in combination with docetaxel induced significant cytotoxicity in PC-3AcT cells compared to parental PC-3 cells. With arctigenin treatment, reactive oxygen species (ROS) levels, annexin V-PE...
Source: Molecular and Cellular Biochemistry - February 16, 2020 Category: Biochemistry Authors: Lee YJ, Nam HS, Cho MK, Lee SH Tags: Mol Cell Biochem Source Type: research

Nickel-refining fumes induce NLRP3 activation dependent on mitochondrial damage and ROS production in Beas-2B cells.
Abstract Nickel (Ni) is a silver-white transition metal that is widely used in the production field due to its unique physical and chemical properties. As a toxicant, long-term exposure to Ni can cause rhinitis, pneumonia and other respiratory inflammation. In the present study, we investigated the effect of particles extracted from Ni-refining fumes on cell viability, inflammation-related proteins and mitochondrial damage in human lung epithelial Beas-2B cells. The cells were exposed to Ni-refining fume particles for 24 h at concentrations of 0, 6.25, 12.50 and 25.00 μg/mL. The expression levels of the NAC...
Source: Archives of Biochemistry and Biophysics - October 9, 2019 Category: Biochemistry Authors: Xin R, Pan YL, Wang Y, Wang SY, Wang R, Xia B, Qin RN, Fu Y, Wu YH Tags: Arch Biochem Biophys Source Type: research

The Opposite Effects of ROCK and Src Kinase Inhibitors on Susceptibility of Eukaryotic Cells to Invasion by Bacteria Serratia grimesii
AbstractBacterial internalization into eukaryotic cells is ensured by a sophisticated interplay of bacterial and host cell factors. Being a part of cell environment, opportunistic intracellular bacteria have developed various mechanisms providing their interaction with cell surface receptors (E-cadherin, integrins, epidermal growth factor receptor), activation of components of eukaryotic signaling pathways, and facilitation of bacterial uptake, survival, and intracellular replication. Our previous studies on the mechanisms underlying penetration of the opportunistic bacteriaSerratia grimesii into cultured eukaryotic cells ...
Source: Biochemistry (Moscow) - May 31, 2019 Category: Biochemistry Source Type: research

DUSP14 knockout accelerates cardiac ischemia reperfusion (IR) injury through activating NF- κB and MAPKs signaling pathways modulated by ROS generation.
DUSP14 knockout accelerates cardiac ischemia reperfusion (IR) injury through activating NF-κB and MAPKs signaling pathways modulated by ROS generation. Biochem Biophys Res Commun. 2018 Apr 13;: Authors: Lin B, Xu J, Feng DG, Wang F, Wang JX, Zhao H Abstract Inflammation and oxidative stress are significantly involved in the progression of a variety of diseases, including myocardial ischemia/reperfusion (IR). In the present study, we hypothesized a protective role of dual-specificity phosphatase 14 (DUSP14) in myocardial IR, as well as the underlying molecular mechanism. The results indicated that DUS...
Source: Biochemical and Biophysical Research communications - April 13, 2018 Category: Biochemistry Authors: Lin B, Xu J, Feng DG, Wang F, Wang JX, Zhao H Tags: Biochem Biophys Res Commun Source Type: research

Inhibition of NLRP9b attenuates acute lung injury through suppressing inflammation, apoptosis and oxidative stress in murine and cell models.
Abstract Acute lung injury (ALI), known a severe disease along with high morbidity and mortality, is lacking of specific therapies. Inflammation, apoptosis and oxidative stress are critical pathologies that contribute to ALI. Recently, there is study indicated that NLRP9b, a NOD-like receptor (NLR) member, is critical in modulation of inflammatory response. However, the effects of NLRP9b on sepsis-associated ALI, and the underlying molecular mechanism have not been understood. In the present study, the wild type (WT) and NLRP9b-knockout (NLRP9b-/-) mice with C57B/L6 background were subjected to a cecal ligation an...
Source: Biochemical and Biophysical Research communications - April 12, 2018 Category: Biochemistry Authors: Yanling Q, Xiaoning C, Fei B, Liyun F, Huizhong H, Daqing S Tags: Biochem Biophys Res Commun Source Type: research

HMGB1 ‐induced asthmatic airway inflammation through GRP75‐mediated enhancement of ER‐mitochondrial Ca2+ transfer and ROS increased
Abstract Imbalanced T‐helper (TH)1/Th2 response contributes significantly to asthma pathogenesis. Our study indicated that HMGB1 play an important role in the release of Th2‐associated cytokines of asthma. However, the specific mechanism about HMGB1‐induced imbalanced TH1/Th2 response is not known. In vivo, an OVA‐induced asthma mouse model was set up and mice treated with anti‐HMGB1 IgG. The mice treated with the anti‐HMGB1 IgG ameliorated airway hyper‐reactivity, disruption of Th1/Th2 balance and the upregulation of GRP75 induced by OVA. In vitro, the exposure of normal human bronchial epithelial cells to H...
Source: Journal of Cellular Biochemistry - January 25, 2018 Category: Biochemistry Authors: Yanhua Lv, Yanli Li, Dandan Zhang, Anbing Zhang, Weihong Guo, Shunfang Zhu Tags: RESEARCH ARTICLE Source Type: research

HMGB1 ‐induced asthmatic airway inflammation through GRP75‐mediated enhancement of ER–Mitochondrial Ca2+ transfer and ROS increased
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Source: Journal of Cellular Biochemistry - January 2, 2018 Category: Biochemistry Authors: Lv Yanhua, Li Yanli, Zhang Dandan, Zhang Anbing, Guo Weihong, Zhu Shunfang Tags: Article Source Type: research