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Anti-inflammatory and anti-fibrotic effects of modafinil in nonalcoholic liver disease
Biomed Pharmacother. 2021 Dec;144:112372. doi: 10.1016/j.biopha.2021.112372. Epub 2021 Oct 28.ABSTRACTSmall- and intermediate-conductance Ca2+-activated K+ channels, KCa2.3 and KCa3.1, are involved in cellular signaling processes associated with inflammation and fibrosis. KCa2.3 and KCa3.1 are upregulated by proinflammatory cytokines and profibrotic growth factors. Cyclic AMP, which downregulates KCa2.3 and KCa3.1, is elevated by modafinil in cells; accordingly, we investigated whether modafinil exerts anti-inflammatory and anti-fibrotic responses via KCa2.3- and KCa3.1-mediated pathways in high-fat diet (HFD)- or thioacet...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 19, 2021 Category: Drugs & Pharmacology Authors: Shinkyu Choi Ji Aee Kim Haiyan Li Seong-Eun Jo Huisu Lee Tae Hun Kim Minje Kim Seong-Jin Kim Suk Hyo Suh Source Type: research

Atractylodin inhibits fructose-induced human podocyte hypermotility via anti-oxidant to down-regulate TRPC6/p-CaMK4 signaling
Eur J Pharmacol. 2021 Nov 12:174616. doi: 10.1016/j.ejphar.2021.174616. Online ahead of print.ABSTRACTHigh fructose has been reported to drive glomerular podocyte oxidative stress and then induce podocyte foot process effacement in vivo, which could be partly regarded as podocyte hypermotility in vitro. Atractylodin possesses anti-oxidative effect. The aim of this study was to explore whether atractylodin prevented against fructose-induced podocyte hypermotility via anti-oxidative property. In fructose-exposed conditionally immortalized human podocytes, we found that atractylodin inhibited podocyte hypermotility, and up-re...
Source: European Journal of Pharmacology - November 15, 2021 Category: Drugs & Pharmacology Authors: Li Chen Ya-Li Tang Zhi-Hong Liu Ying Pan Rui-Qing Jiao Ling-Dong Kong Source Type: research

2-Pyrazine-PPD, a novel dammarane derivative, showed anticancer activity by reactive oxygen species-mediate apoptosis and endoplasmic reticulum stress in gastric cancer cells.
Abstract 20 (R)-Dammarane-3β, 12β, 20, 25-tetrol (25-OH-PPD), a ginsenoside, was derived from Panax ginseng (C. A. Meyer) and inhibited growth of several cancer cell lines. To improve the anti-cancer activity, we introduced the pyrazine ring to 25-OH-PPD and obtained the compound 20(R)-[2,3-β]-Pyrazine-dammarane-12β,20,25-triol (2-Pyrazine-PPD). we evaluated the anti-cancer activity of 2-Pyrazine-PPD and investigated the main anti-cancer mechanisms of 2-Pyrazine-PPD in gastric cancer cells. We found that 2-Pyrazine-PPD remarkably suppressed the proliferation of gastric cancer cells in a concentration-dependent...
Source: European Journal of Pharmacology - May 24, 2020 Category: Drugs & Pharmacology Authors: De Wang X, Li T, Li Y, Yuan WH, Zhao YQ Tags: Eur J Pharmacol Source Type: research

Auranofin, an Anti-rheumatic Gold Drug, Aggravates the Radiation-Induced Acute Intestinal Injury in Mice
Conclusion In this study, we found that a non-toxic dose of auranofin significantly aggravated the severity of the radiation-induced intestinal injury. This suggests that auranofin treatment can be an independent factor that influences the risk of intestinal complications after pelvic or abdominal radiotherapy. Ethics Statement All the protocols used in this study were approved by the Institutional Animal Care and Use Committee of the Korean Institute of Radiological and Medical Sciences (IACUC permit number: KIRAMS217-0007). Author Contributions H-JL, JS, and Y-BL designed the experiments. EL and JK conducted the exp...
Source: Frontiers in Pharmacology - April 23, 2019 Category: Drugs & Pharmacology Source Type: research

The apoptotic effect of Zoledronic acid on the nasopharyngeal carcinoma cells via ROS mediated chloride channel activation.
This article is protected by copyright. All rights reserved. PMID: 29884989 [PubMed - as supplied by publisher]
Source: Clinical and Experimental Pharmacology and Physiology - June 8, 2018 Category: Drugs & Pharmacology Authors: Wang L, Gao H, Yang X, Liang X, Tan Q, Chen Z, Zhao C, Gu Z, Yu M, Zheng Y, Huang Y, Zhu L, Jacob TJC, Wang L, Chen L Tags: Clin Exp Pharmacol Physiol Source Type: research

Suppression of Nrf2 confers chemosensitizing effect through enhanced oxidant-mediated mitochondrial dysfunction.
In this study, we investigated the mechanism of this chemosensitizing effect. MAIN METHODS: KKU-100 cells were used in the study. Nrf2 expression was knocked down by siRNA and expression was validated by reverse transcription and polymerase chain reaction. Cytotoxicity was assessed by sulforhodamine B method. Intracellular reactive oxygen species (ROS) was examined by fluorescent dye, dichlorofluorescin diacetate method and mitochondrial transmembrane potential was assessed by JC1 dye assay. KEY FINDINGS: Cytotoxicity of cisplatin (Cis) in KKU-100 cells was enhanced by knockdown of Nrf2 expression. The enhanced c...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 5, 2018 Category: Drugs & Pharmacology Authors: Sompakdee V, Prawan A, Senggunprai L, Kukongviriyapan U, Samathiwat P, Wandee J, Kukongviriyapan V Tags: Biomed Pharmacother Source Type: research

Roles of ROS and PKC-βII in ionizing radiation-induced eNOS activation in human vascular endothelial cells.
In this study, we investigated early alterations of eNOS signaling in human umbilical venous endothelial cells (HUVECs) exposed to X-ray radiation. We found that ionizing radiation increased eNOS phosphorylation at Ser-1177 and dephosphorylation at Thr-495 in HUVECs in a dose-dependent (≤20 Gy) and time-dependent (6-72 h) manner. The total expression levels of eNOS were unchanged by radiation. Although a transient but significant increase in extracellular signal-regulated protein kinase 1/2 (ERK1/2) phosphorylation and a biphasic decline in Akt phosphorylation were observed after irradiation, these inhibitors were withou...
Source: Vascular Pharmacology - April 10, 2015 Category: Drugs & Pharmacology Authors: Sakata K, Kondo T, Mizuno N, Shoji M, Yasui H, Yamamori T, Inanami O, Yokoo H, Yoshimura N, Hattori Y Tags: Vascul Pharmacol Source Type: research

Oxidized LDL‐induced angiogenesis involves sphingosine 1‐phosphate: prevention by anti‐S1P antibody
Conclusion and ImplicationsThese data highlight the role of S1P in angiogenesis induced by oxLDL both in HMEC‐1 cultured on Matrigel and in vivo in the Matrigel plug model in mice, and demonstrate that the anti‐S1P antibody effectively blocks the angiogenic effect of oxLDL.
Source: British Journal of Pharmacology - November 24, 2014 Category: Drugs & Pharmacology Authors: Caroline Camaré, Magali Trayssac, Barbara Garmy‐Susini, Elodie Mucher, Roger Sabbadini, Robert Salvayre, Anne Negre‐Salvayre Tags: RESEARCH PAPER Source Type: research

Oxidized LDL‐induced angiogenesis involves sphingosine‐1‐phosphate. Prevention by anti‐S1P antibody
Conclusion and ImplicationsThese data emphasize the role of S1P in angiogenesis induced by oxLDL both in HMEC‐1 cultured on Matrigel and in vivo in the Matrigel plug model in mice, and the efficacy of the anti‐S1P antibody in blocking the angiogenic effect of oxLDL.
Source: British Journal of Pharmacology - September 1, 2014 Category: Drugs & Pharmacology Authors: Caroline Camaré, Magali Trayssac, Barbara Garmy‐Susini, Elodie Mucher, Roger Sabbadini, Robert Salvayre, Anne Negre‐Salvayre Tags: Research Paper Source Type: research

Acetylshikonin induces apoptosis of hepatitis B virus X protein-expressing human hepatocellular carcinoma cells via endoplasmic reticulum stress.
Abstract Since it has been known that shikonin derived from a medicinal plant possesses anti-cancer activity, we wonder whether acetylshikonin (ASK), a derivate of shikonin, could be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX), an oncoprotein from hepatitis B virus. When ASK was added to Hep3B cells stably expressing HBX, it induced apoptosis in a dose-dependent manner. ASK induced upregulation and export of Nur77 to the cytoplasm and activation of JNK. Likewise, suppression of Nur77 and JNK inactivation protected the cells from ASK-induced apoptosis, indicating that N...
Source: European Journal of Pharmacology - April 24, 2014 Category: Drugs & Pharmacology Authors: Moon J, Koh SS, Malilas W, Cho IR, Kaewpiboon C, Kaowinn S, Lee K, Jhun BH, Choi YW, Chung YH Tags: Eur J Pharmacol Source Type: research

Glycolaldehyde induces cytotoxicity and increases glutathione and multidrug-resistance-associated protein levels in schwann cells.
Abstract Schwann cell injury is observed in diabetic neuropathy. It is speculated that glycolaldehyde (GA), a precursor of advanced glycation end products (AGEs), contributes to the pathogenesis and development of diabetic neuropathy. Here, we demonstrated for the first time that GA at near-physiological concentration decreased the viability of rat Schwann cells. In contrast, methylglyoxal, glyoxal, and 3-deoxyglucosone, all of which are AGE precursors, had no effects on cell viability. It is well known that methylglyoxal causes oxidative damage. In the present study, however, GA failed to induce reactive oxygen s...
Source: Biological and Pharmaceutical Bulletin - July 6, 2013 Category: Drugs & Pharmacology Authors: Sato K, Tatsunami R, Yama K, Tampo Y Tags: Biol Pharm Bull Source Type: research

Saxifragifolin D induces the interplay between apoptosis and autophagy in breast cancer cells through ROS-dependent endoplasmic reticulum stress.
In conclusion, SD inhibits breast cancer cell growth and induces interplay between apoptosis and autophagy through ROS-mediated endoplasmic reticulum stress. It will provide molecular bases for developing SD into a drug candidate for the treatment of breast cancer. PMID: 23348250 [PubMed - as supplied by publisher]
Source: Biochemical Pharmacology - January 21, 2013 Category: Drugs & Pharmacology Authors: Shi JM, Bai LL, Zhang DM, Yiu A, Yin ZQ, Han WL, Liu JS, Li Y, Fu DY, Ye WC Tags: Biochem Pharmacol Source Type: research