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Total 64 results found since Jan 2013.

Effects of low- and high-frequency electroacupuncture on protein expression and distribution of TRPV1 and P2X3 in rats with peripheral nerve injury.
CONCLUSION: 2- and 100-Hz EA similarly induced analgesic effects in SNI. This effect was related to up-regulation and down-regulation, respectively, of cytosol protein expression of P2X3 and TRPV1 in L4-L6 DRG, with 2 Hz having a better effect than 100 Hz. PMID: 33334124 [PubMed - as supplied by publisher]
Source: Acupuncture in Medicine : journal of the British Medical Acupuncture Society - December 17, 2020 Category: Complementary Medicine Authors: Du J, Fang J, Xiang X, Yu J, Le X, Liang Y, Jin X, Fang J Tags: Acupunct Med Source Type: research

TMEM232 Promotes the Inflammatory Response in Atopic Dermatitis via NF- κB and STAT3 Signaling Pathways
CONCLUSION: The study first outlines the function of TMEM232. It is involved in regulating inflammation in AD and may be a potential target for AD treatment.PMID:36928730 | DOI:10.1093/bjd/ljad078
Source: The British Journal of Dermatology - March 17, 2023 Category: Dermatology Authors: Jie Han Xinying Cai Shichun Qin Zengyunou Zhang Yuanyuan Wu Yuanzhe Shi Tingyue Deng Benjin Chen Li Liu Haisheng Qian Wenliang Fang Fengli Xiao Source Type: research

Adipochemokines induced by ultraviolet irradiation contribute to impaired fat metabolism in subcutaneous fat cells.
CONCLUSIONS: These UV-induced adipochemokines may be implicated in the reduction of lipogenesis in SC fat, leading to impairment of fat homeostasis and associated comorbidities such as obesity. This article is protected by copyright. All rights reserved. PMID: 28845522 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - August 27, 2017 Category: Dermatology Authors: Kim EJ, Kim YK, Kim S, Kim JE, Tian YD, Doh EJ, Lee DH, Chung JH Tags: Br J Dermatol Source Type: research

Abstract B04: RAD51 expression as a biomarker of homologous recombination deficiency in ovarian cancer
RAD51 is a critical component of the homologous recombination pathway, forming a nucleoprotein filament that enables strand exchange and templated error-free DNA repair. The tumor suppressors BRCA1 and BRCA2 interact with RAD51 to control its activity on DNA. Defects in homologous recombination in tumors are clinically relevant, with evidence of synthetic lethality of such cancers to poly ADP ribose polymerase (PARP) inhibitors.Mutations in RAD51 are uncommon in cancer, but aberrant over-expression of RAD51 has been reported as a mechanism to overcome a recombination defect in in-vitro models. However there are no large sc...
Source: Molecular Cancer Therapeutics - October 2, 2017 Category: Cancer & Oncology Authors: Hoppe, M. M., Tan, D. S., Lim, D. G., Karnezis, A., Huntsman, D., Steel, J., Liu, X., Paul, J., Lewsley, L.-A., Siddiqui, N., Brown, R., Jeyasekharan, A. D. Tags: New Technology and Bioinformatics: Poster Presentations - Proffered Abstracts Source Type: research

G α12 facilitates shortening in human airway smooth muscle by modulating phosphoinositide 3‐kinase‐mediated activation in a RhoA‐dependent manner
Conclusions and ImplicationsGα12 plays a crucial role in HASMC contraction via RhoA‐dependent activation of the PI3K/ROCK axis. Inhibition of RhoA activation induces bronchodilation in hPCLS, and targeting Gα12 signaling may elucidate novel therapeutic targets in asthma. These findings provide alternative approaches to the clinical management of airway obstruction in asthma.
Source: British Journal of Pharmacology - November 12, 2017 Category: Drugs & Pharmacology Authors: Edwin J Yoo, Gaoyuan Cao, Cynthia J Koziol ‐White, Christie A Ojiaku, Krishna Sunder, Joseph A Jude, James V Michael, Hong Lam, Ivan Pushkarsky, Robert Damoiseaux, Dino Di Carlo, Kwangmi Ahn, Steven S An, Raymond B Penn, Reynold A Panettieri Tags: RESEARCH PAPER Source Type: research

Effects of corilagin on alleviating cholestasis via FXR ‐associated pathways in vitro and in vivo
CONCLUSIONS AND IMPLICATIONSCorilagin exerts a protective effect in hepatocytes and can rescue the deleterious activities of intrahepatic cholestasis by stimulating FXR‐associated pathways.
Source: British Journal of Pharmacology - December 1, 2017 Category: Drugs & Pharmacology Authors: Fan Yang, Yao Wang, Gang Li, Juan Xue, Zhi ‐Lin Chen, Feng Jin, Lei Luo, Xuan Zhou, Qian Ma, Xin Cai, Hua‐Rong Li, Lei Zhao Tags: RESEARCH PAPER Source Type: research

Effects of corilagin on alleviating cholestasis via farnesoid X receptor ‐associated pathways in vitro and in vivo
Conclusions and ImplicationsCorilagin exerts a protective effect in hepatocytes and can prevent the deleterious activities of intrahepatic cholestasis by stimulating FXR‐associated pathways.
Source: British Journal of Pharmacology - January 25, 2018 Category: Drugs & Pharmacology Authors: Fan Yang, Yao Wang, Gang Li, Juan Xue, Zhi ‐Lin Chen, Feng Jin, Lei Luo, Xuan Zhou, Qian Ma, Xin Cai, Hua‐Rong Li, Lei Zhao Tags: RESEARCH PAPER Source Type: research

Interleukin-32 promotes detachment and activation of human Langerhans cells in a human skin explant model.
CONCLUSIONS: We propose, for the first time, that IL-32 is a molecular link between KCs and LCs in healthy skin, provoking LC migration from the epidermis to the dermis prior to their migration to the draining lymph nodes. PMID: 29806155 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - May 28, 2018 Category: Dermatology Authors: Gonnet J, Perrin H, Hutton AJ, Boccara D, Bonduelle O, Mimoun M, Atlan M, Soria A, Combadière B Tags: Br J Dermatol Source Type: research

Targeted therapy for the post-operative conjunctiva: SPARC silencing reduces collagen deposition.
CONCLUSIONS: SPARC targeted therapy effectively reduced both SPARC and collagen production in the operated mouse conjunctiva. This proof-of-concept study suggests that targeted treatment of fibrosis in glaucoma surgery is safe and feasible, with the potential to extend to a range of potential genes associated with fibrosis. PMID: 30021812 [PubMed - as supplied by publisher]
Source: The British Journal of Ophthalmology - July 18, 2018 Category: Opthalmology Authors: Seet LF, Tan YF, Toh LZ, Chu SW, Lee YS, Venkatraman SS, Wong TT Tags: Br J Ophthalmol Source Type: research

Engineered Extracellular Vesicles From Human Periodontal-Ligament Stem Cells Increase VEGF/VEGFR2 Expression During Bone Regeneration
Conclusion In conclusion our results evidenced that 3D-COL/hPDLSCs/PEI-EVs may be an efficacious strategy to induce bone regeneration and vascularization of bone defects, thanks to its capacity to increase the levels of VEGF. Ethics Statement The study was performed in accordance with the guidelines of the Helsinki Declaration (2013). The written approval for the human periodontal ligament collection performed in this study has been obtained from the Medical Ethics Committee at the Medical School, “G. d’Annunzio” University of Chieti–Pescara, Chieti, Italy (n°266/17.04.14, Principal in...
Source: Frontiers in Physiology - April 29, 2019 Category: Physiology Source Type: research

Human CAR NK Cells: A New Non-viral Method Allowing High Efficient Transfection and Strong Tumor Cell Killing
In conclusion, the method of NK cell transfection described in our present study is highly efficient, does not require expensive dedicated structures necessary for viral transduction and avoids possible risks associated with the use of viral vectors. Importantly, it may be applied to NK cells or NK-92 cell line, greatly improving their anti-tumor activity and providing a new NK cell-based platform for new protocols of adoptive immuno-therapy of cancer. Ethics Statement The Ethical Committee of IRCCS Bambino Gesù Pediatric Hospital approved the study (825/2014). Author Contributions TI designed and performed res...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

Upregulated E3 ligase Trim21 in psoriatic epidermis ubiquitylates NF- κB p65 subunit and promotes inflammation in keratinocytes.
CONCLUSIONS: Our study confirms that upregulated Trim21 in psoriatic epidermis ubiquitylates p65 and activates the NF-κB pathway, which promotes keratinocyte inflammation. Hence, Trim21 represents a potential target for psoriasis treatment. PMID: 32232831 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - March 29, 2020 Category: Dermatology Authors: Yang L, Zhang T, Zhang C, Xiao C, Bai X, Wang G Tags: Br J Dermatol Source Type: research