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Condition: Blindness

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Total 95 results found since Jan 2013.

HMGB-1 as a Potential Target for the Treatment of Diabetic Retinopathy.
CONCLUSIONS As a therapeutic target, HMGB-1 can inhibit inflammation and promote RGCs survival to delay DR progress through the HMGB-1-TLR4-NF-κB signaling pathway. PMID: 26454330 [PubMed - as supplied by publisher]
Source: Medical Science Monitor - October 14, 2015 Category: Research Tags: Med Sci Monit Source Type: research

Mitochondrial DNA has a pro-inflammatory role in AMD
This study contributes to our understanding of the potential pro-inflammatory role of mtDNA in the pathogenesis of AMD. Graphical abstract
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - September 7, 2015 Category: Molecular Biology Source Type: research

PTB-associated splicing factor inhibits IGF-1-induced VEGF upregulation in a mouse model of oxygen-induced retinopathy
Abstract Pathological retinal neovascularization, including retinopathy of prematurity and age-related macular degeneration, is the most common cause of blindness worldwide. Insulin-like growth factor-1 (IGF-1) has a direct mitogenic effect on endothelial cells, which is the basis of angiogenesis. Vascular endothelial growth factor (VEGF) activation in response to IGF-1 is well documented; however, the molecular mechanisms responsible for the termination of IGF-1 signaling are still not completely elucidated. Here, we show that the polypyrimidine tract-binding protein-associated splicing factor (PSF) is a potentia...
Source: Cell and Tissue Research - January 31, 2015 Category: Cytology Source Type: research

Angiopoietin-Like Protein 2 Is a Potent Hemangiogenic and Lymphangiogenic Factor in Corneal Inflammation Cornea
Conclusions. Our findings demonstrated Angptl2 to be upregulated in corneal inflammation, and highlight that corneal hemangiogenesis and lymphangiogenesis may be driven by Angptk2 overexpression via macrophage infiltration and IL-1β expression. Angptl2 may be a novel therapeutic target for preventing blindness.
Source: Investigative Ophthalmology - June 26, 2013 Category: Opthalmology Authors: Toyono, T., Usui, T., Yokoo, S., Kimakura, M., Nakagawa, S., Yamagami, S., Miyata, K., Oike, Y., Amano, S. Tags: Cornea Source Type: research

Moesin as a key cytoskeleton regulator in corneal fibrosis.
CONCLUSIONS: : Moesin may be a potential drug target for inhibiting corneal fibrosis, and the details of moesin-related signaling pathways would be critical for understanding corneal fibrosis. PMID: 23583046 [PubMed - in process]
Source: The Ocular Surface - April 1, 2013 Category: Opthalmology Authors: Zhu HY, Yeo SW, Ng J, Htoon HM, Beuerman RW Tags: Ocul Surf Source Type: research