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Condition: Blindness
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Total 95 results found since Jan 2013.
Inhibition of heat shock protein 47 suppressed collagen production in Tenon's capsule fibroblasts
CONCLUSIONS: HSP47 siRNA inhibits the production of COLI in rat Tenon's fibroblasts, and may be the potential therapeutic method in bleb scarring after glaucoma filtration surgery.PMID:37724035 | DOI:10.5603/fhc.96514
Source: Folia Histochemica et Cytobiologica - September 19, 2023 Category: Cytology Authors: Weiwei Wang Haiyan lI Source Type: research
AMPK protects endothelial cells against HSV-1 replication via inhibition of mTORC1 and ACC1
Microbiol Spectr. 2023 Sep 13:e0041723. doi: 10.1128/spectrum.00417-23. Online ahead of print.ABSTRACTHerpes simplex virus type 1 (HSV-1) is a widespread contagious pathogen, mostly causing mild symptoms on the mucosal entry side. However, systemic distribution, in particular upon reactivation of the virus in immunocompromised patients, may trigger an innate immune response and induce damage of organs. In these conditions, HSV-1 may infect vascular endothelial cells, but little is known about the regulation of HSV-1 replication and possible defense mechanisms in these cells. The current study addresses the question of whet...
Source: Herpes - September 13, 2023 Category: Infectious Diseases Authors: Heena Doshi Katrin Spengler Amod Godbole Yi Sing Gee Jonathan Baell Jonathan S Oakhill Andreas Henke Regine Heller Source Type: research
MIR34A modulates lens epithelial cell apoptosis and cataract development via the HK1/caspase 3 signaling pathway
Aging (Albany NY). 2023 Jul 6;15. doi: 10.18632/aging.204854. Online ahead of print.ABSTRACTCataracts are the leading cause of blindness in the world. Age is a major risk factor for cataracts, and with increasing aging, the burden of cataracts will grow, but the exact details of cataractogenesis remain unclear. A recent study showed that microRNA-34a (MIR34A) is involved in the development of cataracts, but the underlying pathogenesis remains obscure. Here, our results of microRNA target prediction showed that hexokinase 1 (HK1) is one of the genes targeted by MIR34A. Based on this finding, we focused on the function of MI...
Source: Aging - July 6, 2023 Category: Biomedical Science Authors: Lujia Feng Yantao Wei Yimeng Sun Linbin Zhou Shaowei Bi Weirong Chen Wu Xiang Source Type: research
Mechanisms of MALAT1 regulating proliferative diabetic retinopathy via targeting miR-126-5p
CONCLUSIONS: MALAT1 promotes PDR by inhibiting miR126-5p and inducing REC proliferation, migration and angiogenesis.PMID:37303661 | PMC:PMC10251023
Source: American Journal of Translational Research - June 12, 2023 Category: Research Authors: Wei Zhao Yanli Liu Cairui Li Zhijian Yin Yi Liu Meixia An Source Type: research
