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Condition: Blindness
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Total 95 results found since Jan 2013.
Adenovirus-mediated RNA interference against herpes simplex virus infection in vitro
CONCLUSIONS: Adenovirus-mediated siRNA-targeting gD and gE genes effectively inhibit the replication of the HSV in Vero cells. In addition, these findings indicate that the prophylactic use of siRNA is far more effective at inhibiting HSV replication than the therapeutic use.PMID:34905214 | DOI:10.5603/FHC.a2021.0031
Source: Folia Histochemica et Cytobiologica - December 14, 2021 Category: Cytology Authors: Lin Chen Zhi-Qiang Pan Chang-Bin Zhai Source Type: research
High glucose induces HSP47 expression and promotes the secretion of inflammatory factors through the IRE1 α/XBP1/HIF-1α pathway in retinal Müller cells
Exp Ther Med. 2021 Dec;22(6):1411. doi: 10.3892/etm.2021.10847. Epub 2021 Oct 7.ABSTRACTDiabetic retinopathy, a common complication of diabetes, is the leading cause of blindness globally. Müller cells are key players in diabetes-associated retinal inflammation and dysfunction. However, the pathological changes of Müller cells in response to high glucose (HG) and the underlying mechanism remain unclear. The aim of the present study was to investigate the key role of heat shock protein 47 (HSP47) in HG-induced unfolded protein and inflammatory responses. Primary mouse Müller cells were starved in serum-free DMEM overnigh...
Source: Experimental and Therapeutic Medicine - October 22, 2021 Category: General Medicine Authors: Xincheng Sun Chen Chen Hu Liu Shaowen Tang Source Type: research
The AhR ligand 2, 2'-aminophenyl indole (2AI) regulates microglia homeostasis and reduces pro-inflammatory signaling
Biochem Biophys Res Commun. 2021 Sep 23;579:15-21. doi: 10.1016/j.bbrc.2021.09.054. Online ahead of print.ABSTRACTRetinal degeneration is a leading cause of visual impairment and blindness worldwide. Microglia reactivity is a hallmark of neurodegenerative diseases and a driving force for retinal cell death and disease progression. Thus, immunomodulation emerges as a potential therapeutic option. AhR deficiency is known to trigger inflammation and previous studies revealed important roles for AhR ligands in neuroprotection without focusing on microglia. Here, we investigate the anti-inflammatory and antioxidant effects of t...
Source: Biochemical and Biophysical Research communications - September 28, 2021 Category: Biochemistry Authors: Amir Saeed Khan Anne Wolf Thomas Langmann Source Type: research
miR-23a-3p regulates the proliferation and apoptosis of human lens epithelial cells by targeting Bcl-2 in an < em > in vitro < /em > model of cataracts
In conclusion, the findings of the current study suggested that the inhibition of miR-23a-3p may attenuate H2O2-induced cataract formation by targeting BCL2, thus providing a novel therapeutic target for the treatment of patients with cataracts in the clinic.PMID:33777189 | PMC:PMC7967796 | DOI:10.3892/etm.2021.9853
Source: Experimental and Therapeutic Medicine - March 29, 2021 Category: General Medicine Authors: Pengxiang Yao Jian Jiang Xiaoping Ma Zhenzhong Chen Yufang Hong Yang Wu Source Type: research
