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Condition: Proteinuria
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Total 100 results found since Jan 2013.
Mitochondria-Targeted CoQ < sub > 10 < /sub > Loaded PLGA-b-PEG-TPP Nanoparticles: Their Effects on Mitochondrial Functions of COQ8B < sup > -/- < /sup > HK-2 cells
Eur J Pharm Biopharm. 2022 Feb 26:S0939-6411(22)00039-X. doi: 10.1016/j.ejpb.2022.02.018. Online ahead of print.ABSTRACTCoenzyme Q10 (CoQ10) deficiency exhibits signs of multiple organ dysfunctions, particular subtypes present isolated kidney involvement progressing to chronic kidney disease. In these patients, early administration of oral CoQ10 has been shown to decrease proteinuria and to delay development of chronic kidney disease, which suggests that it may have a renoprotective potential in these patients. However, CoQ10 bioavailability in mitochondria is low, therefore its efficacy is limited. We aimed to develop mit...
Source: European Journal of Pharmaceutics and Biopharmaceutics - March 1, 2022 Category: Drugs & Pharmacology Authors: Hamide Sena Ozbay Samiye Yabanoglu-Ciftci Ipek Baysal Merve Gultekinoglu Cemil Can Eylem Kezban Ulubayram Emirhan Nemutlu Rezan Topaloglu Fatih Ozaltin Source Type: research
Up ‐Regulated Interleukin‐10 Induced by E2F Transcription Factor 2–MicroRNA‐17‐5p Circuitry in Extrafollicular Effector B Cells Contributes to Autoantibody Production in Systemic Lupus Erythematosus
ConclusionIL-10 promotes extrafollicular autoimmune responses in patients with active SLE, which might be dampened by targeting theE2F2–miR-17-5p circuitry.
Source: Arthritis and Rheumatology - February 9, 2022 Category: Rheumatology Authors: Lingxiao Xu,
Lei Wang,
Yumeng Shi,
Yun Deng,
Jim C. Oates,
Diane L. Kamen,
Gary S. Gilkeson,
Fang Wang,
Miaojia Zhang,
Wenfeng Tan,
Betty P. Tsao Tags: Full Length Source Type: research
Chinese Herbal Medicine Suyin Detoxification Granule Inhibits Pyroptosis and Epithelial-Mesenchymal Transition by Downregulating MAVS/NLRP3 to Alleviate Renal Injury
CONCLUSION: SDP protected renal tubular epithelial cells from cell pyroptosis and EMT by regulating the albumin-induced mitochondrial dysfunction/ MAVS/ NLRP3-ASC-caspase-1 inflammasome signaling pathway.PMID:34908861 | PMC:PMC8665879 | DOI:10.2147/JIR.S341598
Source: Cell Research - December 15, 2021 Category: Cytology Authors: Yiye Zhu Guoshun Huang Yang Yang Chen Yong Xiang Yu Gang Wang Lan Yi Kun Gao Fang Tian Shushu Qian Enchao Zhou Yanqin Zou Source Type: research
Upregulated IL ‐10 induced by E2F2‐miR‐17‐5p circuitry in extrafollicular effector B cells contributes to autoantibody production in systemic lupus erythematosus
ConclusionIL10 promotes extrafollicular autoimmune responses in active SLE patients, which might be dampened by targeting theE2F2-miR-17-5p circuitry.
Source: Arthritis and Rheumatology - September 27, 2021 Category: Rheumatology Authors: Lingxiao Xu,
Lei Wang,
Yumeng Shi,
Yun Deng,
Jim C. Oates,
Diane L. Kamen,
Gary S. Gilkeson,
Fang Wang,
Miaojia Zhang,
Wenfeng Tan,
Betty P. Tsao Tags: FULL LENGTH Source Type: research
Synbindin Downregulation Participates in Slit Diaphragm Dysfunction
CONCLUSION: Synbindin participates in maintaining foot processes and slit diaphragm as a downstream molecule of SV2B-mediated vesicle transport. Synbindin downregulation participates in slit diaphragm dysfunction. Synbindin can be an early marker to detect podocyte injury.PMID:34515036 | DOI:10.1159/000517975
Source: American Journal of Nephrology - September 13, 2021 Category: Urology & Nephrology Authors: Veniamin Ivanov Yoshiyasu Fukusumi Ying Zhang Hidenori Yasuda Meiko Kitazawa Hiroshi Kawachi Source Type: research
IL-6/STAT3 signaling activation exacerbates high fructose-induced podocyte hypertrophy by ketohexokinase-A-mediated tristetraprolin down-regulation
Cell Signal. 2021 Jul 9:110082. doi: 10.1016/j.cellsig.2021.110082. Online ahead of print.ABSTRACTGlomerular hypertrophy is a crucial factor of severe podocyte damage and proteinuria. Our previous study showed that high fructose induced podocyte injury. The current study aimed to explore a novel molecular mechanism underlying podocyte hypertrophy induced by high fructose. Here we demonstrated for the first time that high fructose significantly initiated the hypertrophy in rat glomeruli and differentiated human podocytes (HPCs). Consistently, it induced inflammatory response with the down-regulation of anti-inflammatory fac...
Source: Cellular Signalling - July 12, 2021 Category: Cytology Authors: Jie Zhou Jie Yang Yu-Meng Wang Hong Ding Tu-Shuai Li Zhi-Hong Liu Li Chen Rui-Qing Jiao Dong-Mei Zhang Ling-Dong Kong Source Type: research
ATF4-dependent heme-oxygenase-1 attenuates diabetic nephropathy by inducing autophagy and inhibiting apoptosis in podocyte
CONCLUSIONS: ATF4 induces autophagy by enhancing the expression of HO-1, and inhibits podocyte apoptosis in DN. Treatment with the HO-1 agonist reduced proteinuria, apoptosis, and enhanced autophagy response, and thus improved renal function in DN mice.PMID:34157937 | DOI:10.1080/0886022X.2021.1936040
Source: Renal Failure - June 23, 2021 Category: Urology & Nephrology Authors: Shizhu Yuan Xudong Liang Wenfang He Mingzhu Liang Juan Jin Qiang He Source Type: research
