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Tangshen Formula Alleviates Hepatic Steatosis by Inducing Autophagy Through the AMPK/SIRT1 Pathway
Conclusion In conclusion, the present study demonstrated that autophagy was involved in relieving the effects of TSF against NAFLD, which were mediated by the AMPK/SIRT1 pathway (Figure 7D). These findings may improve our current understanding of the role of TSF in treating hepatic steatosis and provide an experimental basis for the clinical application of TSF in NAFLD and its related metabolic syndrome. Ethics Statement This study was carried out in accordance with the recommendations in the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health. The protocol was approved by the Ethics Co...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

NF κB and Kidney Injury
Conclusion As a critical regulator of inflammation and cell survival, the NFκB pathway is a promising target for diagnosing and treating kidney diseases. For modulation of the NFκB pathway in the clinic, a number of molecules can effectively inhibit NFκB signaling by targeting the receptors, associated adaptors, IKKs, IκBs and transcriptional regulators (144). There is further clinical evidence on small-molecule inhibitors of IKKα and NIK from recent trials on anti-cancer therapies (145). These clinical trials showed that the cancer-selective pharmacodynamic response of DTP3, the co...
Source: Frontiers in Immunology - April 15, 2019 Category: Allergy & Immunology Source Type: research

Curcumin protects against fructose‐induced podocyte insulin signaling impairment through upregulation of miR‐206
ConclusionCurcumin is suggested to activate miR‐206 expression to downregulate PTP1B, and then improve insulin signaling, protect against fructose‐induced glomerular podocyte injury, and proteinuria, which may provide new evidence regarding curcumin's effects on fructose‐associated podocyte injury.
Source: Molecular Nutrition and Food Research - October 15, 2015 Category: Food Science Authors: Xiao‐Qin Ding, Ting‐Ting Gu, Wei Wang, Lin Song, Tian‐Yu Chen, Qiao‐Chu Xue, Fan Zhou, Jian‐Mei Li, Ling‐Dong Kong Tags: Research Article Source Type: research

Curcumin protects against fructose‐induced podocyte insulin signaling impairment through up‐regulation of miR‐206
ConclusionCurcumin may activate miR‐206 expression to down‐regulate PTP1B, and then improve insulin signaling, protect against fructose‐induced glomerular podocyte injury and proteinuria, which may provide new evidence regarding curcumin's effects on fructose‐associated podocyte injury.This article is protected by copyright. All rights reserved
Source: Nahrung / Food - September 23, 2015 Category: Nutrition Authors: Xiao‐Qin Ding, Ting‐Ting Gu, Wei Wang, Lin Song, Tian‐Yu Chen, Qiao‐Chu Xue, Fan Zhou, Jian‐Mei Li, Ling‐Dong Kong Tags: Research Article Source Type: research

Insulin increases glomerular filtration barrier permeability through PKGIα-dependent mobilization of BKCa channels in cultured rat podocytes
Publication date: August 2015 Source:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Volume 1852, Issue 8 Author(s): Agnieszka Piwkowska , Dorota Rogacka , Irena Audzeyenka , Małgorzata Kasztan , Stefan Angielski , Maciej Jankowski Podocytes are highly specialized cells that wrap around glomerular capillaries and comprise a key component of the glomerular filtration barrier. They are uniquely sensitive to insulin; like skeletal muscle and fat cells, they exhibit insulin-stimulated glucose uptake and express glucose transporters. Podocyte insulin signaling is mediated by protein kinase G type I (PKGI), ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - June 2, 2015 Category: Molecular Biology Source Type: research

Insulin increases glomerular filtration barrier permeability through PKGIα-dependent mobilization of BKCa channels in cultured rat podocytes.
Abstract Podocytes are highly specialized cells that wrap around glomerular capillaries and comprise a key component of the glomerular filtration barrier. They are uniquely sensitive to insulin; like skeletal muscle and fat cells, they exhibit insulin-stimulated glucose uptake and express glucose transporters. Podocyte insulin signaling is mediated by protein kinase G type I (PKGI), and it leads to changes in glomerular permeability to albumin. Here, we investigated whether large-conductance Ca(2+)-activated K(+) channels (BKCa) were involved in insulin-mediated, PKGIα-dependent filtration barrier permeability. I...
Source: Biochimica et Biophysica Acta - May 4, 2015 Category: Biochemistry Authors: Piwkowska A, Rogacka D, Audzeyenka I, Kasztan M, Angielski S, Jankowski M Tags: Biochim Biophys Acta Source Type: research