Filtered By:
Specialty: Orthopaedics
Condition: Osteoporosis

This page shows you your search results in order of date.

Order by Relevance | Date

Total 16 results found since Jan 2013.

Glucocorticoids Disrupt Skeletal Angiogenesis Through Transrepression of NF ‐κB–Mediated Preosteoclast Pdgfb Transcription in Young Mice
ABSTRACTIn the growing skeleton, angiogenesis is intimately coupled with osteogenesis. Chronic, high doses of glucocorticoids (GCs) are associated with decreased bone vasculature and induce osteoporosis and growth failure. The mechanism of GC ‐suppression of angiogenesis and relationship to osteoporosis and growth retardation remains largely unknown. Type H vessels, which are regulated by preosteoclast (POC) platelet‐derived growth factor–BB (PDGF‐BB), are specifically coupled with bone formation and development. We determined th e effect of GCs on POC synthesis of PDGF‐BB in relation to type H vessel formation, ...
Source: Journal of Bone and Mineral Research - March 30, 2020 Category: Orthopaedics Authors: Yi Peng, Shan Lv, Yusheng Li, Jianxi Zhu, Shijie Chen, Gehua Zhen, Xu Cao, Song Wu, Janet L. Crane Tags: Original Article Source Type: research

Glucocorticoids disrupt skeletal angiogenesis through transrepression of NF ‐κB‐mediated preosteoclast Pdgfb transcription in young mice
This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - February 27, 2020 Category: Orthopaedics Authors: Yi Peng, Shan Lv, Yusheng Li, Jianxi Zhu, Shijie Chen, Gehua Zhen, Xu Cao, Song Wu, Janet L. Crane Tags: Original Article Source Type: research

Sinusoidal Electromagnetic Fields Increase Peak Bone Mass in Rats by Activating Wnt10b/ β‐Catenin in Primary Cilia of Osteoblasts
ABSTRACTExtremely low ‐frequency electromagnetic fields have been considered a potential candidate for the prevention and treatment of osteoporosis; however, their action mechanism and optimal magnetic flux density (intensity) parameter are still elusive. The present study found that 50‐Hz sinusoidal electromagnetic fields (SEMFs) at 1.8 mT increased the peak bone mass of young rats by increasing bone formation. Gene array expression studies with femoral bone samples showed that SEMFs increased the expression levels of collagen‐1α1 and Wnt10b, a critical ligand of the osteogenic Wnt/β‐catenin pathway. Con sistent...
Source: Journal of Bone and Mineral Research - July 14, 2019 Category: Orthopaedics Authors: Jian Zhou, Yu ‐Hai Gao, Bao‐Ying Zhu, Jia‐Le Shao, Hui‐Ping Ma, Cory J Xian, Ke‐Ming Chen Tags: Original Article Source Type: research

Sinusoidal electromagnetic fields increase peak bone mass in rats by activating Wnt10b/ β‐catenin in primary cilia of osteoblasts
This article is protected by copyright. All rights reserved
Source: Journal of Bone and Mineral Research - February 19, 2019 Category: Orthopaedics Authors: Jian Zhou, Yu ‐Hai Gao, Bao‐Ying Zhu, Jia‐Le Shao, Hui‐Ping Ma, Cory J Xian, Ke‐Ming Chen Tags: Original Article Source Type: research

Role of plasminogen activator inhibitor-1 in glucocorticoid-induced muscle change in mice
In conclusion, our data suggest that paracrine PAI-1 is involved in GC-induced muscle wasting through the enhancement of muscle degradation in mice.
Source: Journal of Bone and Mineral Metabolism - March 19, 2017 Category: Orthopaedics Source Type: research

Heterozygous PTCH1 Mutations Impact the Bone Metabolism in Patients with Nevoid Basal Cell Carcinoma Syndrome Likely by Regulating SPARC Expression
This study sought to investigate the mechanism underlying heterozygous PTCH1 mutation‐mediated abnormal bone metabolism in patients with NBCCS. Stromal cells were isolated from the fibrous capsules of patients with NBCCS‐associated or non‐syndromic keratocystic odontogenic tumors and non‐syndromic tumor stromal cells without PTCH1 mutations served as controls. Germline PTCH1 heterozygous mutations were confirmed in all NBCCS samples and differential protein expression was identified using tandem mass tag‐labeled proteomics analysis. Our findings revealed that osteonectin/SPARC expression was significantly downreg...
Source: Journal of Bone and Mineral Research - February 17, 2016 Category: Orthopaedics Authors: Yingying Hong, Jianyun Zhang, Heyu Zhang, Xuefen Li, Jiafei Qu, Jiemei Zhai, Lei Zhang, Feng Chen, Tiejun Li Tags: Original Article Source Type: research

Src siRNA prevents corticosteroid-associated osteoporosis in a rabbit model
In an established steroid-associated osteonecrosis (SAON) rabbit model we found recently that blockage Src by siRNA could improve reconstructive repair of osteonecrosis via enhancing osteogenesis and inhibiting bone resorption. The current study investigated if blocking Src was able to prevent steroid-associated osteoporosis (SAOP) in the same SAON animal model. Rabbits were treated with pulsed lipopolysaccharide (LPS) and corticosteroid methylprednisolone (MPS). At 2, 4, 6weeks after induction, Src siRNA, control siRNA and saline were intramedullary injected into proximal femur, respectively.
Source: Bone - November 17, 2015 Category: Orthopaedics Authors: Li-Zhen Zheng, Xin-Luan Wang, Hui-Juan Cao, Shi-Hui Chen, Le Huang, Ling Qin Tags: Original Full Length Article Source Type: research

The effects of muscle contraction and recombinant osteocalcin on insulin sensitivity ex vivo
Conclusions GPRC6A, the likely receptor of osteocalcin (OC), is expressed in mouse muscle. ucOC treatment augments insulin-stimulated skeletal muscle glucose uptake in C2C12 myotubes and following ex vivo muscle contraction. ucOC may partly account for the insulin sensitizing effect of exercise.
Source: Osteoporosis International - August 10, 2015 Category: Orthopaedics Source Type: research

Anabolic Bone Formation Via a Site‐Specific Bone‐Targeting Delivery System by Interfering With Semaphorin 4d Expression
ABSTRACT Semaphorins have been recently targeted as new molecules directly implicated in the cell‐cell communication that occurs between osteoclasts and osteoblasts. Overexpression of certain semaphorins, such as semaphorin4D (sema4D), is found in an osteoporotic phenotype and plays a key role in osteoclast activity by suppressing osteoblast maturation, thus significantly altering the bone modeling cycle. In the present study, we fabricate a site‐specific bone‐targeting drug‐delivery system from polymeric nanoparticles with the incorporation of siRNA interference molecule for sema4D and demonstrate their cellular u...
Source: Journal of Bone and Mineral Research - January 22, 2015 Category: Orthopaedics Authors: Yufeng Zhang, Lingfei Wei, Richard J Miron, Bin Shi, Zhuan Bian Tags: Original Article Source Type: research

Increased RANKL-mediated osteoclastogenesis by interleukin-1β and endoplasmic reticulum stress
Conclusions Osteoclastogenesis by IL-1β and/or ER stress is mainly associated with upregulation of eIF2α, GRP78, PERK and IRE1. These results suggest that the signaling pathway of ER stress-induced osteoclast formation might be a new therapeutic target to prevent inflammatory and destructive arthritic disease such as RA and diverse osteoporosis.
Source: Joint Bone Spine - December 12, 2014 Category: Orthopaedics Source Type: research

Functional analyses reveal the essential role of SOX6 and RUNX2 in the communication of chondrocyte and osteoblast
Conclusions Our study first reveals that SOX6 and RUNX2 play important roles in the chondrogenesis–osteogenesis coordination. This finding enriches the limited understanding about this coordination and unravels the novel function of SOX6 and RUNX2 in the endochondral ossification.
Source: Osteoporosis International - September 12, 2014 Category: Orthopaedics Source Type: research