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Condition: Hypertension
Drug: Losartan

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Total 16 results found since Jan 2013.

Integrin subunit β-like 1 mediates angiotensin II-induced myocardial fibrosis by regulating the forkhead box Q1/Snail axis
Arch Biochem Biophys. 2022 Sep 29:109422. doi: 10.1016/j.abb.2022.109422. Online ahead of print.ABSTRACTCardiac fibrosis is a severe condition with limited therapeutic options and often occurs in chronic cardiovascular diseases such as hypertension and myocardial infarction. There is currently a clear need to identify novel mediators of cardiac fibrosis to facilitate the development of more effective therapeutic strategies targeting cardiac fibrosis. Integrin subunit β-like 1 (ITGBL1), an extracellular matrix protein, has previously been implicated in various fibrotic diseases. However, the precise role of ITGBL1 in regul...
Source: Archives of Biochemistry and Biophysics - October 2, 2022 Category: Biochemistry Authors: Hui Zhu Hongxue Ji Weiming Chen Lu Han Liangzhu Yu Source Type: research

Calcitriol ameliorates renal injury with high-salt diet-induced hypertension by upregulating GLIS2 expression and AMPK/mTOR-regulated autophagy
Gene. 2022 Jan 31:146239. doi: 10.1016/j.gene.2022.146239. Online ahead of print.ABSTRACTThe goal of the present study was to investigate the protective effect of calcitriol on high-salt diet-induced hypertension. The hypertension rat model was established by a long-term high-salt diet (8% NaCl). Rats were treated with calcitriol, losartan, or their combination. Histological staining was used to confirm renal pathology. Global transcriptome analysis of renal tissues was performed, and the mechanism of the therapeutic effect of calcitriol was analysed by functional annotation and pathway analysis of the differentially expre...
Source: Gene - February 3, 2022 Category: Genetics & Stem Cells Authors: Ruifeng Ding Yufeng Jiang Yi Yang Yong Shi Yang Ji Timing Zhen Zhiliang Fu Xunxia Bao Jia Tan Shuyong Zhang Jiahui Li Kaichen Xing Xinli Zhou Sibo Zhu Source Type: research

Sirtuin1 contributes to the overexpression of Giα proteins and hyperproliferation of vascular smooth muscle cells from spontaneously hypertensive rats
Conclusion: In summary, our results demonstrate that Sirt1 is overexpressed in VSMC from SHR which through augmenting oxidative stress contributes to the enhanced expression of Giα proteins, cell cycle proteins and resultant hyperproliferation of VSMC.
Source: Journal of Hypertension - December 10, 2021 Category: Cardiology Tags: ORIGINAL ARTICLES Source Type: research

Angiotensin II -induced overexpression of Sirtuin-1 contributes to enhanced expression of Gi α proteins and hyperproliferation of vascular smooth muscle cells
Am J Physiol Heart Circ Physiol. 2021 Jul 16. doi: 10.1152/ajpheart.00898.2020. Online ahead of print.ABSTRACTAngiotensin II (Ang II) plays an important role in the regulation of various physiological functions including proliferation, hypertrophy of vascular smooth muscle cells (VSMC) through the overexpression of Giα proteins. Sirtuin1 (Sirt1), a class III histone deacetylase and epigenetic regulator is implicated in a wide range of cellular functions, including migration and growth of VSMC as well as in Ang II-induced hypertension. The present study was undertaken to examine the role of Sirt1 in Ang II-induced overexpr...
Source: American Journal of Physiology. Heart and Circulatory Physiology - July 16, 2021 Category: Physiology Authors: Ekhtear Hossain Yuan Li Madhu B Anand-Srivastava Source Type: research

G Protein-Coupled Estrogen Receptor Protects From Angiotensin II-Induced Increases in Pulse Pressure and Oxidative Stress
Our previous work showed that the G protein-coupled estrogen receptor (GPER) is protective in the vasculature and kidneys during angiotensin (Ang) II-dependent hypertension by inhibiting oxidative stress. The goal of the current study was to assess the impact of GPER deletion on sex differences in Ang II-induced hypertension and oxidative stress. Male and female wildtype and GPER knockout mice were implanted with radiotelemetry probes for measurement of baseline blood pressure before infusion of Ang II (700 ng/kg/min) for two weeks. Mean arterial pressure was increased to the same extent in all groups, but female wildtype ...
Source: Frontiers in Endocrinology - August 26, 2019 Category: Endocrinology Source Type: research

AT1 Receptors in the Subfornical Organ Modulate Arterial Pressure and the Baroreflex In Two-kidney One-clip Hypertensive Rats.
Abstract The subfornical organ (SFO), a forebrain circumventricular organ that lies outside the blood brain barrier, has been implicated in arterial pressure and baroreflex responses to angiotensin II (Ang II). We tested whether pharmacologic inhibition or selective silencing of SFO AT1 receptors (AT1R) of two-kidney one-clip rats with elevated plasma Ang II decreases resting arterial pressure and renal sympathetic nerve activity (RSNA) and/or modulates arterial baroreflex responses of heart rate and RSNA. Male Sprague Dawley rats underwent renal artery clipping (2K-1C) or sham-clipping (Sham). Six weeks later, co...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - January 9, 2019 Category: Physiology Authors: Rossi NF, Zenner Z, Rishi AK, Levi E, Maliszewska-Scislo M Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research

Abstract 5109: The CARMA3-Bcl10-MALT1 signalosome mediates NF-{kappa}B activation and cellular invasion in AGTR1-positive breast cancer
Angiotensin II (Ang II) is a potent vasoconstrictor and vascular pro-inflammatory mediator, known classically for its role in promoting arterial dysfunction. Many of these pathogenic effects result from activation of NF-κB in response to stimulation of the type-1 Ang II receptor (AGTR1), a G protein-coupled receptor. We previously discovered that a complex composed of three proteins, CARMA3, Bcl10 and MALT1 (CBM signalosome) mediates AGTR1-dependent activation of NF-κB in vascular cells. Despite its principal role in vascular pathobiology, we recently found that AGTR1 is aberrantly overexpressed in 10-20% of breast cance...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Ekambaram, P., Hubel, N., Lee, J.-Y., Klei, L., Concel, V., Delekta, P., Tomlins, S., McAllister-Lucas, L., Lucas, P. Tags: Tumor Biology Source Type: research

Angiotensin II regulates brain (pro)renin receptor expression through activation of cAMP response element-binding protein
We reported that brain (pro)renin receptor (PRR) expression levels are elevated in DOCA-salt-induced hypertension; however, the underlying mechanism remained unknown. To address whether ANG II type 1 receptor (AT1R) signaling is involved in this regulation, we implanted a DOCA pellet and supplied 0.9% saline as the drinking solution to C57BL/6J mice. Sham pellet-implanted mice that were provided regular drinking water served as controls. Concurrently, mice were intracerebroventricularly infused with the AT1R blocker losartan, angiotensin-converting-enzyme inhibitor captopril, or artificial cerebrospinal fluid for 3 wk. Int...
Source: AJP: Regulatory, Integrative and Comparative Physiology - July 15, 2015 Category: Physiology Authors: Li, W., Liu, J., Hammond, S. L., Tjalkens, R. B., Saifudeen, Z., Feng, Y. Tags: Cardiovascular and Renal Integration Source Type: research