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Condition: Ischemic Stroke

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Total 193 results found since Jan 2013.

Retinoic Acid Prevents the Neuronal Damage Through the Regulation of Parvalbumin in an Ischemic Stroke Model
In conclusion, retinoic acid contributes to the preservation of neurons from ischemic stroke by controlling parvalbumin expression and apoptosis-related proteins.PMID:36245066 | DOI:10.1007/s11064-022-03769-9
Source: Neurochemical Research - October 16, 2022 Category: Neuroscience Authors: Ju-Bin Kang Dong-Ju Park Phil-Ok Koh Source Type: research

Maternally Expressed Gene 3 negatively regulated Decorin to Supresse Angiogenesis, Proliferation and Migration of Endothelial Cells
CONCLUSION: Our study demonstrated the anti-growth effects of MEG3 on vasculogenesis and migration of endothelial cells. Thus, by blocking the expression of Decorin in HUVECs, the overexpression of MEG3 repressed their development and might potentially alleviate the ischemic stroke.PMID:36443969 | DOI:10.2174/1566524023666221128150800
Source: Current Molecular Medicine - November 29, 2022 Category: Molecular Biology Authors: Dongwei Dai Lei Zhang Qiong Lu Jin Li Yunhai Di Chun'ou Tian Jianmin Liu Bo Hong Source Type: research

MiR-199a-5p enhances neuronal differentiation of neural stem cells and promotes neurogenesis by targeting Cav-1 after cerebral ischemia
CONCLUSION: MiR-199a-5p may target and inhibit Cav-1 to enhance neurogenesis and thus promote functional recovery after cerebral ischemia. These findings indicate that miR-199a-5p is a promising target for the treatment of ischemic stroke.PMID:37349971 | DOI:10.1111/cns.14323
Source: CNS Neuroscience and Therapeutics - June 23, 2023 Category: Neuroscience Authors: Hua-Qian Jin Wei-Feng Jiang Xin-Tian Zheng Lin Li Yan Fang Yan Yang Xiao-Wei Hu Li-Sheng Chu Source Type: research

MicroRNA-193a-5p Rescues Ischemic Cerebral Injury by Restoring N2-Like Neutrophil Subsets
In conclusion, miR-193a-5p protects against cerebral ischemic injury by restoring neutrophil N2 phenotype-associated neuroinflammation suppr ession, likely, in part, via UBE2V2 induction.
Source: Translational Stroke Research - June 29, 2023 Category: Neurology Source Type: research

Nanoparticle-mediated delivery of microRNAs-based therapies for treatment of disorders
Pathol Res Pract. 2023 Jul 3;248:154667. doi: 10.1016/j.prp.2023.154667. Online ahead of print.ABSTRACTmiRNAs represent appropriate candidates for treatment of several disorders. However, safe and efficient delivery of these small-sized transcripts has been challenging. Nanoparticle-based delivery of miRNAs has been used for treatment of a variety of disorders, particularly cancers as well as ischemic stroke and pulmonary fibrosis. The wide range application of this type of therapy is based on the important roles of miRNAs in the regulation of cell behavior in physiological and pathological conditions. Besides, the ability...
Source: Pathology, Research and Practice - July 9, 2023 Category: Pathology Authors: Soudeh Ghafouri-Fard Hamed Shoorei Leili Noferesti Bashdar Mahmud Hussen Mohammad Hossein Behzad Moghadam Mohammad Taheri Fariborz Rashnoo Source Type: research

SLC26A11 Inhibition Reduces Oncotic Neuronal Death and Attenuates Stroke Reperfusion Injury
In this study, electrophysiological properties of chloride current in primary cultured neurons were characterized using low chloride solution, 4,4 ′-diisothiocyano-2,2′-stilbenedisulfonic acid, and SLC26A11-specific siRNA under physiological conditions or ATP-depleted conditions. In vivo effect of SLC26A11 was evaluated on a rat stroke reperfusion model. We found that SLC26A11 mRNA in primary cultured neurons was upregulated as early as 6  h after oxygen glucose deprivation, and later, the protein level was elevated accordingly. Blockade of SLC26A11 activity could reduce chloride entry and attenuate hypoxia-induced ne...
Source: Molecular Neurobiology - September 1, 2023 Category: Neurology Source Type: research