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Interference with the expression of S1PR1 or STAT3 attenuates valvular damage due to rheumatic heart disease
Int J Mol Med. 2021 Sep;48(3):179. doi: 10.3892/ijmm.2021.5012. Epub 2021 Jul 23.ABSTRACTRheumatic heart disease (RHD) affects numerous individuals annually; however, its pathogenesis remains unclear. The sphingosine 1‑phosphate receptor 1 (S1PR1) and signal transducer and activator of transcription 3 (STAT3) have recently been shown to be involved in valvular damage via the promotion of the differentiation of T helper 17 (Th17) cells during the development of RHD‑induced valvular damage. The present study investigated whether altering the expression of S1PR1 or STAT3 attenuates valvular damage due to RHD. Inactivated ...
Source: International Journal of Molecular Medicine - July 23, 2021 Category: Molecular Biology Authors: Shenglin Xian Ang Chen Yunjiao Wu Hong Wen Chuanghong Lu Feng Huang Zhiyu Zeng Source Type: research

HDAC1 and 2 regulate endothelial VCAM-1 expression and atherogenesis by suppressing methylation of the GATA6 promoter
Conclusions: HDAC1/2 contributes to VCAM-1 expression and atherosclerosis by suppressing STAT3 acetylation-dependent GATA6 promoter methylation. These findings may provide a rationale for HDAC1/2-targeting therapy in atherosclerotic heart disease.
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Chengxiu Hu, Kai Peng, Qianqian Wu, Yiying Wang, Xing Fan, Dai-Min Zhang, Anthony G. Passerini, ChongXiu Sun Tags: Research Paper Source Type: research

Irisin attenuates angiotensin II-induced cardiac fibrosis via Nrf2 mediated inhibition of ROS/ TGF β1/Smad2/3 signaling axis.
In this study, we found that angiotensin II-induced cardiac dysfunction and fibrotic responses were dampened by irisin treatment in mice. Mechanistically, angiotensin II induced robust ROS generation, which in turn triggered activation of pro-fibrotic TGFβ1-Smad2/3 signaling and subsequent collagen synthesis and fibroblast-myofibroblast transformation in cardiac fibroblasts. In contrast, Irisin treatment suppressed angiotensin II-induced ROS generation, TGFβ1 activation, collagen synthesis and fibroblast-myofibroblast transformation, the effects of which was accompanied by Nrf2 activation and also abolished by a Nrf2 tar...
Source: Chemico-Biological Interactions - January 28, 2019 Category: Molecular Biology Authors: Chen RR, Fan XH, Chen G, Zeng GW, Xue YG, Liu XT, Wang CY Tags: Chem Biol Interact Source Type: research

Mineralocorticoid receptor deficiency improves the therapeutic effects of mesenchymal stem cells for myocardial infarction via enhanced cell survival.
Abstract The poor survival of stem cells seriously limits their therapeutic efficacy for myocardial infarction (MI). Mineralocorticoid receptor (MR) activation plays an important role in the pathogenesis of multiple cardiovascular diseases. Here, we examined whether MR silencing in bone marrow derived mesenchymal stem cells (MSCs) could improve MSCs' survival and enhance their cardioprotective effects in MI. MSCs from male Sprague-Dawley rats were transfected with adenoviral small interfering RNA to silence MR (siRNA-MR). MR silencing decreased hypoxia-induced MSCs' apoptosis, as demonstrated by Annexin V/7-AAD st...
Source: J Cell Mol Med - December 13, 2018 Category: Molecular Biology Authors: Xie X, Shen Y, Chen J, Huang Z, Ge J Tags: J Cell Mol Med Source Type: research

Transgelin as a potential target in the reversibility of pulmonary arterial hypertension secondary to congenital heart disease.
CONCLUSIONS: Transgelin may be a potential target in the development of irreversible CHD-PAH through inducing PASMC phenotype change, proliferation, migration and reducing cell apoptosis. PMID: 30338626 [PubMed - as supplied by publisher]
Source: J Cell Mol Med - October 18, 2018 Category: Molecular Biology Authors: Huang L, Li L, Yang T, Li W, Song L, Meng X, Gu Q, Xiong C, He J Tags: J Cell Mol Med Source Type: research

PEDF improves cardiac function in rats subjected to myocardial ischemia/reperfusion injury by inhibiting ROS generation via PEDF ‑R.
PEDF improves cardiac function in rats subjected to myocardial ischemia/reperfusion injury by inhibiting ROS generation via PEDF‑R. Int J Mol Med. 2018 Mar 09;: Authors: Zhao Q, Liu Z, Huang B, Yuan Y, Liu X, Zhang H, Qiu F, Zhang Y, Li Y, Miao H, Dong H, Zhang Z Abstract The prevention and management of myocardial ischemia/reperfusion (MI/R) injury is an essential part of coronary heart disease surgery and is becoming a major clinical problem in the treatment of ischemic heart disease. Previous studies by our group have demonstrated that pigment epithelium‑derived factor (PEDF) improves cardiac f...
Source: International Journal of Molecular Medicine - March 9, 2018 Category: Molecular Biology Authors: Zhao Q, Liu Z, Huang B, Yuan Y, Liu X, Zhang H, Qiu F, Zhang Y, Li Y, Miao H, Dong H, Zhang Z Tags: Int J Mol Med Source Type: research

Bakuchiol attenuates myocardial ischemia reperfusion injury by maintaining mitochondrial function: the role of silent information regulator 1
This study was designed to investigate the protective effects of BAK treatment in the setting of myocardial IRI and to elucidate the potential mechanism of those effects. Prior to induction of IR, isolated rat hearts or cardiomyocytes were exposed to BAK in either the absence or presence of the SIRT1 inhibitors Sirtinol and SIRT1 siRNA. BAK exerted cardioprotective effects, as evidenced by the improvements noted in cardiac function following ischemia, attenuated myocardial apoptosis, and changes in several biochemical parameters (including increases in the level of the anti-apoptotic protein Bcl2, decreases in the level of...
Source: Apoptosis - March 21, 2016 Category: Molecular Biology Source Type: research