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Exendin-4 Improves Cognitive Function of Diabetic Mice via Increasing Brain Insulin Synthesis
CONCLUSION: This study demonstrated that Ex-4 improved cognition function by promoting brain in- sulin synthesis followed by the activation of brain insulin signaling and alleviation of tau hyper- phosphorylation.PMID:34587885 | DOI:10.2174/1567205018666210929150004
Source: Current Alzheimer Research - September 30, 2021 Category: Neurology Authors: Xuemin Peng Xiaoli Shi Jiaojiao Huang Shujun Zhang Yongli Yan Delin Ma Weijie Xu Weijie Xu Kun Dong Jing Tao Mengni Li Yan Yang Source Type: research

AGE-Induced Suppression of EZH2 Mediates Injury of Podocytes by Reducing H3K27me3
Conclusions: Our studies provide a novel pathway how AGEs contribute to podocyte injury and the formation of the so-called metabolic memory in DKD.Am J Nephrol
Source: American Journal of Nephrology - August 27, 2020 Category: Neurology Source Type: research

DNA binding protein HMGB1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with OSA
Publication date: Available online 18 June 2018 Source:Brain, Behavior, and Immunity Author(s): Yu Shi, Xiangyu Guo, Jie Zhang, Hanchi Zhou, Bei Sun, Jing Feng Type 2 diabetes mellitus (T2DM) complicated with obstructive sleep apnea (OSA) may cause neuronal apoptosis and cognitive deficits, but the underlying mechanisms remain unclear. We aimed to determine the relationship between the activation of microglia and the apoptosis of hippocampal neurons, specifically in terms of high mobility group box-1 (HMGB1), after high glucose (HG) and intermittent hypoxia (IH) exposure. Diabetic KK-Ay mice and non-diabetic C57BL/6J mice...
Source: Brain, Behavior, and Immunity - June 19, 2018 Category: Neurology Source Type: research

DNA binding protein HMGB1 secreted by activated microglia promotes the apoptosis of hippocampal neurons in diabetes complicated with OSA.
Abstract Type 2 diabetes mellitus (T2DM) complicated with obstructive sleep apnea (OSA) may cause neuronal apoptosis and cognitive deficits, but the underlying mechanisms remain unclear. We aimed to determine the relationship between the activation of microglia and the apoptosis of hippocampal neurons, specifically in terms of high mobility group box-1 (HMGB1), after high glucose (HG) and intermittent hypoxia (IH) exposure. Diabetic KK-Ay mice and non-diabetic C57BL/6J mice (C57 mice) underwent IH or normoxia (control) exposure for 4 weeks. Cognitive function, microglial activation and hippocampal neuronal apoptos...
Source: Brain, Behavior, and Immunity - June 16, 2018 Category: Neurology Authors: Shi Y, Guo X, Zhang J, Zhou H, Sun B, Feng J Tags: Brain Behav Immun Source Type: research

LncRNA NONRATT021972 Was Associated with Neuropathic Pain Scoring in Patients with Type 2 Diabetes.
CONCLUSION: LncRNA NONRATT021972 increased in type 2 diabetes and was positively associated with neuropathic pain scoring in type 2 diabetes. LncRNA NONRATT021972 exacerbated neuropathic pain via TNF-α related pathways. PMID: 28928602 [PubMed - in process]
Source: Behavioural Neurology - September 22, 2017 Category: Neurology Authors: Yu W, Zhao GQ, Cao RJ, Zhu ZH, Li K Tags: Behav Neurol Source Type: research

A Hypothalamic Leptin-Glutamate Interaction in the Regulation of Sympathetic Nerve Activity.
In conclusion, these studies provide evidence that within the hypothalamic nuclei, leptin-glutamate signaling regulates the sympathetic activation. This may contribute to the sympathoexcitation commonly observed in obesity-related T2D. PMID: 28845307 [PubMed - in process]
Source: Neural Plasticity - August 30, 2017 Category: Neurology Authors: Zheng H, Liu X, Li Y, Patel KP Tags: Neural Plast Source Type: research

lncRNA NONRATT021972 siRNA Decreases Diabetic Neuropathic Pain Mediated by the P2X 3 Receptor in Dorsal Root Ganglia
Abstract Long noncoding RNAs (lncRNAs) participate in physiological and pathophysiological processes. Type 2 diabetes mellitus (T2DM) accounts for more than 90 % of all cases of diabetes mellitus (DM). Diabetic neuropathic pain (DNP) is a common complication of T2DM. The aim of this study was to investigate the effects of lncRNA NONRATT021972 small interference RNA (siRNA) on DNP mediated by the P2X3 receptor in dorsal root ganglia (DRG). These experiments showed that the expression levels of NONRATT021972 in DRG were increased in the T2DM rat model (intraperitoneal injection of STZ with 30 mg/kg). The concentra...
Source: Molecular Neurobiology - January 7, 2016 Category: Neurology Source Type: research