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Condition: Chronic Obstructive Pulmonary
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Total 173 results found since Jan 2013.
Apigenin Alleviates Oxidative Stress-Induced Cellular Senescence via Modulation of the SIRT1-NADFormula: see text-CD38 Axis
In this study, we selected the hydrogen peroxide (H2O[Formula: see text]- or doxorubicin (DOXO)-induced senescence model in WI-38 human embryonic lung fibroblast cells to determine the potential anti-aging effects of apigenin in vitro and associated molecular mechanisms. We found that apigenin reduced senescence-associated [Formula: see text]-galactosidase (SA-[Formula: see text]-gal) activity and promoted cell growth, concomitant with a decrease in levels of Acetyl (ac)-p53, p21[Formula: see text], and p16[Formula: see text] and an increase in phospho (p)-Rb. Apigenin also increased the activation ratio of silent informat...
Source: The American Journal of Chinese Medicine - May 29, 2021 Category: Complementary Medicine Authors: Bing Si Li Ri Zhe Zhu Seok-Hee Lim Jae Ho Seo Byung-Min Choi Source Type: research
Epithelium-derived IL17A Promotes Cigarette Smoke-induced Inflammation and Mucus Hyperproduction
In this study, we aim to determine whether epithelial-derived IL17A regulates inflammation and mucus hyperproduction in COPD using a cultured human bronchial epithelial (HBE) cell line in vitro and airway epithelium IL17A-specific knockout mouse in vivo. Increased IL17A expression was observed in mouse airway epithelium upon cigarette smoke (CS) exposure or in a COPD mouse model that was induced by CS and elastin. CS extract (CSE) also triggered IL17A expression in HBE cells. Blocking IL17A or IL17RA effectively attenuated CSE-induced MUC5AC and the inflammatory cytokines IL6, tumor necrosis factor (TNF)-α, and IL1β in H...
Source: Mol Biol Cell - June 29, 2021 Category: Molecular Biology Authors: Mindan Wu Tianwen Lai Du Jing Shiyi Yang Yanping Wu Zhouyang Li Yinfang Wu Yun Zhao Lingren Zhou Haipin Chen Jiaxin Shen Wen Li Songmin Ying Zhihua Chen Xiaohong Wu Huahao Shen Source Type: research
Effects of allyl isothiocyanate on the expression, function, and its mechanism of ABCA1 and ABCG1 in pulmonary of COPD rats
CONCLUSION: These results suggest that AITC improves COPD by promoting RCT process and reducing inflammatory response via activating LXR pathways.PMID:34802946 | DOI:10.1016/j.intimp.2021.108373
Source: International Immunopharmacology - November 22, 2021 Category: Allergy & Immunology Authors: Wen-Tao Zhu Chen-Hui Li Ting-Ting Dai Fu-Lin Tao Meng-Wen Wang Chong-Yang Wang Zhi-Li Han Nian-Xia Sun Ya-Nan Zhao Dian-Lei Wang Source Type: research
Involvement of < em > NEAT1 < /em > /PINK1-mediated mitophagy in chronic obstructive pulmonary disease induced by cigarette smoke or PM < sub > 2.5 < /sub >
CONCLUSIONS: Our results suggest that CS and PM2.5 exposure induce mitochondrial dysfunction, and the NEAT1/PINK1 pathway plays a critical role in the occurrence and development of COPD by regulating mitophagy.PMID:35433942 | PMC:PMC9011272 | DOI:10.21037/atm-22-542
Source: Cancer Control - April 18, 2022 Category: Cancer & Oncology Authors: Qi Lin Chao-Feng Zhang Jin-Ling Guo Jian-Lin Su Zhen-Kun Guo Huang-Yuan Li Source Type: research
Hydrogen sulfide alleviates particulate matter-induced emphysema and airway inflammation by suppressing ferroptosis
CONCLUSION: This research suggested that H2S alleviated PM-induced emphysema and airway inflammation via restoring redox balance and inhibiting ferroptosis through regulating Nrf2-PPAR-ferritinophagy signaling pathway.PMID:35490984 | DOI:10.1016/j.freeradbiomed.2022.04.014
Source: Free Radical Biology and Medicine - May 1, 2022 Category: Biology Authors: Ying Wang Sha Liao Zihan Pan Simin Jiang Jing Fan Siwang Yu Lixiang Xue Jianling Yang Shaohua Ma Tong Liu Jing Zhang Yahong Chen Source Type: research
