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Condition: Chronic Obstructive Pulmonary
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Total 173 results found since Jan 2013.
LL-37 and HMGB1 induce alveolar damage and reduce lung tissue regeneration via RAGE
Am J Physiol Lung Cell Mol Physiol. 2021 Aug 18. doi: 10.1152/ajplung.00138.2021. Online ahead of print.ABSTRACTThe receptor for advanced glycation end-products (RAGE) has been implicated in the pathophysiology of chronic obstructive pulmonary disease (COPD). However, it is still unknown whether RAGE directly contributes to alveolar epithelial damage and abnormal repair responses. We hypothesize that RAGE activation not only induces lung tissue damage but also hampers alveolar epithelial repair responses. The effects of the RAGE ligands LL-37 and HMGB1 were examined on airway inflammation and alveolar tissue damage in wild...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - August 18, 2021 Category: Cytology Authors: Simon D Pouwels Laura Hesse Xinhui Wu Venkata Sita Rama Raju Allam Daan van Oldeniel Linsey J Bhiekharie Simon Phipps Brian G G Oliver Reinoud Gosens Maria Sukkar Irene H Heijink Source Type: research
Cigarette Smoke Promotes Interleukin-8 Production in Alveolar Macrophages Through the Reactive Oxygen Species/Stromal Interaction Molecule 1/Ca2+ Axis
In conclusion, our study demonstrates that CSE-induced ROS production may increase the expression of STIM1 in macrophages, which further promotes the release of IL-8 by regulating Ca2+ entry. These data suggest that STIM1 may play a crucial role in CSE-induced ROS production and inflammation, and participate in the pathogenesis of COPD.
Source: Frontiers in Physiology - October 8, 2021 Category: Physiology Source Type: research
The role of retinoid-related orphan receptor- α in cigarette smoke-induced autophagic response
CONCLUSIONS: Our findings suggest that RORα promotes autophagy and contributes to COPD pathogenesis via regulation of the RORα-p53-DRAM pathway.PMID:35509068 | DOI:10.1186/s12931-022-02034-5
Source: Cell Research - May 5, 2022 Category: Cytology Authors: Hak-Su Kim Chang Hyeok An Danielle Teller Su-Jin Moon Gi Won Hwang Jin Woo Song Source Type: research
Interleukin-6 neutralizing antibody attenuates the hypersecretion of airway mucus via inducing the nuclear translocation of Nrf2 in chronic obstructive pulmonary disease
Biomed Pharmacother. 2022 Jun 7;152:113244. doi: 10.1016/j.biopha.2022.113244. Online ahead of print.ABSTRACTAirway mucus hypersecretion is a vital pathophysiologic feature in chronic obstructive pulmonary disease (COPD) patients in which airflow limitation result, and it is key to strategizing in the management of COPD. To investigate the mechanisms underlying the action of interleukin-6 neutralizing antibody (IL-6 Ab) in attenuating airway mucus hypersecretion in COPD, human and mouse primary bronchial epithelial cells from COPD patients and mice were isolated, human organoid model of trachea was established and all trea...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - June 10, 2022 Category: Drugs & Pharmacology Authors: Yuan-Yuan Wei Da-Wei Zhang Jing-Jing Ye Qing-Xia Lan Shuang Ji Li Sun Fang Li Guang-He Fei Source Type: research
