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Total 16 results found since Jan 2013.

Molecules, Vol. 28, Pages 97: Alpha Ketoglutarate Downregulates the Neutral Endopeptidase and Enhances the Growth Inhibitory Activity of Thiorphan in Highly Aggressive Osteosarcoma Cells
sińska Since natural substances are widely explored as epigenetic modulators of gene expression and epigenetic abnormalities are important causes of cancerogenesis, factors with pro-tumor activities subjected to epigenetic control, e.g., neutral endopeptidase (NEP, neprilysin), are promising anticancer targets for potential therapies acting via epigenetic regulation of gene expression. Alpha-ketoglutarate (AKG) is a naturally occurring co-substrate for enzymes involved in histone and DNA demethylation with suggested anti-cancer activity. Hence, we investigated a potential effect of AKG on the NEP expression in cells d...
Source: Molecules - December 22, 2022 Category: Chemistry Authors: Magdalena Mizerska-Kowalska Adrianna S ławińska-Brych Emilia Niedziela Viktor Brodovskiy Barbara Zdzisi ńska Tags: Article Source Type: research

Effects of long noncoding RNA AK093407 on the biological behavior of colon cancer cells and the underlying mechanism
CONCLUSION: These results showed that knockdown of AK093407 could inhibit colon cancer cell proliferation, induce apoptosis and cell cycle arrest, influence the expression of vital factors in mitochondrial apoptosis pathway and cell cycle regulatory pathway, and may negatively regulate JAK/STAT3 through down-regulating p-Stat3.PMID:35400339 | DOI:10.2174/1386207325666220408092028
Source: Combinatorial Chemistry and High Throughput Screening - April 11, 2022 Category: Chemistry Authors: Zhao Xuerong Sun Ao Wang Jianping Zheng Xin Tian Duoduo Wang Mingjuan Xiao Lijun Zhao Enhong Zheng-Guo Cui Source Type: research

PCSK9 as a new player in cancer: New opportunity or red herring?
Curr Med Chem. 2021 Nov 15. doi: 10.2174/0929867328666211115122324. Online ahead of print.ABSTRACTInitially described as a factor involved in liver regeneration and neuronal differentiation, proprotein convertase subtilisin/kexin type 9 (PCSK9) has become one of the key regulators of low-density lipoprotein cholesterol. Besides that, a number of studies have suggested PCSK9 may play a role in cancer biology. This is particularly true for gastroenteric (gastric and liver cancers) and lung cancers, where higher PCSK9 levels were associated with the increased ability of the tumor to develop and give metastasis as well as with...
Source: Current Medicinal Chemistry - November 16, 2021 Category: Chemistry Authors: Aldo Bonaventura Alessandra Vecchi é Massimiliano Ruscica Francesco Grossi Francesco Dentali Source Type: research

The Application of the RNA Interference Technologies for KRAS: Current Status, Future Perspective and Associated Challenges.
Abstract KRAS is a member of the murine sarcoma virus oncogene-RAS gene family. It plays an important role in the prevention, diagnosis and treatment of tumors during tumor cell growth and angiogenesis. KRAS is the most commonly mutated oncogene in human cancers, such as the pancreatic cancers, colon cancers, and lung cancers. Detection of KRAS gene mutation is an important indicator for tracking the status of oncogenes, illuminating the developmental prognosis of various cancers, and the efficacy of radiotherapy and chemotherapy. However, the efficacy of different patients in clinical treatment is not the same. S...
Source: Current Topics in Medicinal Chemistry - August 27, 2019 Category: Chemistry Authors: Shao YT, Ma L, Zhang TH, Xu TR, Ye YC, Liu Y Tags: Curr Top Med Chem Source Type: research

SERPINA3 Silencing Inhibits the Migration, Invasion, and Liver Metastasis of Colon Cancer Cells.
CONCLUSION: SERPINA3 silencing could inhibit the migration, invasion, and liver metastasis of colon cancer cells. PMID: 29855767 [PubMed - as supplied by publisher]
Source: Anal Sci - May 31, 2018 Category: Chemistry Authors: Cao LL, Pei XF, Qiao X, Yu J, Ye H, Xi CL, Wang PY, Gong ZL Tags: Dig Dis Sci Source Type: research

Gossypol induces death receptor-5 through activation of ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL. Additions and Corrections
This article has been retracted by the publisher. An investigation at MD Anderson determined that image of control HCT116 cells treated with TRAIL and the image of cells transfected with CHOP siRNA and treated with TRAIL in Fig. 5C were reused. Additionally, the Journal determined that the actin immunoblot in Fig. 2A was reused as the actin immunoblot in Fig. 3B; the control/TRAIL treated image had been reused in the DR5/Gossypol+TRAIL and in the scrambled siRNA/TRAIL images in Fig. 4B; the scrambled siRNA/Gossypol image from Fig. 4B was reused as the NAC image in Fig. 7C; and the control/Gossypol image was reused as the C...
Source: Journal of Biological Chemistry - August 4, 2016 Category: Chemistry Authors: Sung, B., Ravindran, J., Prasad, S., Pandey, M. K., Aggarwal, B. B. Tags: Additions and Corrections Source Type: research

Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax. Additions and Corrections
This article has been retracted by the publisher. An investigation at MD Anderson determined that the image of medium control and the image of DR4+DR5 siRNA treated with TRAIL in Fig. 3B were reused.
Source: Journal of Biological Chemistry - August 4, 2016 Category: Chemistry Authors: Gupta, S. C., Reuter, S., Phromnoi, K., Park, B., Hema, P. S., Nair, M., Aggarwal, B. B. Tags: Additions and Corrections Source Type: research

Modulation of Cyclin D1 Expression by PKC{alpha} and PKC{epsi} Gene Regulation
Cellular accumulation of cyclin D1, a key regulator of cell proliferation and tumorigenesis, is subject to tight control. Our previous studies have identified PKCα as a negative regulator of cyclin D1 in the intestinal epithelium. However, treatment of non-transformed IEC-18 ileal crypt cells with PKC agonists has a biphasic effect on cyclin D1 expression. Initial PKCα-mediated down-regulation is followed by recovery and subsequent accumulation of the cyclin to levels markedly higher than those seen in untreated cells. Using protein overexpression strategies, siRNA, and pharmacological inhibitors, we now demonstrate that...
Source: Journal of Biological Chemistry - August 7, 2014 Category: Chemistry Authors: Pysz, M. A., Hao, F., Hizli, A. A., Lum, M. A., Swetzig, W. M., Black, A. R., Black, J. D. Tags: Signal Transduction Source Type: research

Wnt9A Expression Increased by Decline in Arylsulfatase B Molecular Bases of Disease
In this study, the novel transcriptional mechanism by which carrageenan and decline in ARSB increase Wnt9A expression in NCM460 and HT-29 human colonic epithelial cells and in mouse colon is presented. Increased expression of Wnt9A has been associated with multiple malignancies, including colon carcinoma, and with ectodermal and mesoendodermal morphogenesis. When ARSB activity was reduced by siRNA or by exposure to carrageenan (1 μg/ml for 24 h), degradation of chondroitin 4-sulfate (C4S) was inhibited, leading to accumulation of more highly sulfated C4S, which binds less galectin-3, a β-galactoside-binding protein. Nucl...
Source: Journal of Biological Chemistry - June 19, 2014 Category: Chemistry Authors: Bhattacharyya, S., Feferman, L., Tobacman, J. K. Tags: Glycobiology and Extracellular Matrices Source Type: research

{beta}1Pix Interacts Directly with {beta}-Catenin Cell Biology
We report the novel observations that β1Pix binds directly to β-catenin, an action requiring both the β1Pix DH and dimerization domains but not β1Pix GEF activity. In human colon cancer cells, activation of β-catenin signaling with LiCl decreased β1Pix/β-catenin association in the cytosol and increased nuclear binding of β-catenin to β1Pix. Nuclear association of β1Pix and β-catenin was independent of Rac1 expression and activation; down- and up-regulating Rac1 expression levels did not alter nuclear β1Pix/β-catenin association. Ectopic β1Pix expression enhanced LiCl-induced β-catenin transcriptional activit...
Source: Journal of Biological Chemistry - November 22, 2013 Category: Chemistry Authors: Chahdi, A., Raufman, J.-P. Tags: Signal Transduction Source Type: research

Pyrido2,3-dpyrimidines: Discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors.
Abstract DYRK1B is a kinase over-expressed in certain cancer cells (including colon, ovarian, pancreatic, etc.). Recent publications have demonstrated inhibition of DYRK1B could be an attractive target for cancer therapy. From a data-mining effort, the team has discovered analogues of pyrido[2,3-d]pyrimidines as potent enantio-selective inhibitors of DYRK1B. Cells treated with a tool compound from this series showed the same cellular effects as down regulation of DYRK1B with siRNA. Such effects are consistent with the proposed mechanism of action. Progress of the SAR study is presented. PMID: 24239188 [PubMed...
Source: Bioorganic and Medicinal Chemistry Letters - November 1, 2013 Category: Chemistry Authors: Anderson K, Chen Y, Chen Z, Dominique R, Glenn K, He Y, Janson C, Luk KC, Lukacs C, Polonskaia A, Qiao Q, Railkar A, Rossman P, Sun H, Xiang Q, Vilenchik M, Wovkulich P, Zhang X Tags: Bioorg Med Chem Lett Source Type: research

HnRNPK Regulates 3' End RNA Processing at EGR1 DNA and Chromosomes
The heterogeneous nuclear ribonucleoprotein K (hnRNPK) is a nucleic acid-binding protein that acts as a docking platform integrating signal transduction pathways to nucleic acid-related processes. Given that hnRNPK could be involved in other steps that compose gene expression the definition of its genome-wide occupancy is important to better understand its role in transcription and co-transcriptional processes. Here, we used chromatin immunoprecipitation followed by deep sequencing (ChIP-Seq) to analyze the genome-wide hnRNPK-DNA interaction in colon cancer cell line HCT116. 9.1/3.6 and 7.0/3.4 million tags were sequenced/...
Source: Journal of Biological Chemistry - August 23, 2013 Category: Chemistry Authors: Mikula, M., Bomsztyk, K., Goryca, K., Chojnowski, K., Ostrowski, J. Tags: Gene Regulation Source Type: research