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Cancer: Neuroblastoma
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Total 288 results found since Jan 2013.
Ultrathin SU-8 membrane for highly efficient tunable cell patterning and massively parallel large biomolecular delivery
This study presents a novel and efficient technique that enables massively parallel high throughput cell patterning and precise delivery of small to large biomolecules into patterned cells. The innovative cell patterning device proposed in this study is a standalone, ultrathin 3D SU-8 micro-stencil membrane, with a thickness of 10 μm. It features an array of micro-holes ranging from 40 μm to 80 μm, spaced apart by 50 μm to 150 μm. By culturing cells on top of this SU-8 membrane, the technique achieves highly efficient cell patterns varying from single-cell to cell clusters on a Petri dish. Utilizing this technique, we...
Source: Cancer Control - September 1, 2023 Category: Cancer & Oncology Authors: Pallavi Shinde Ashwini Shinde Srabani Kar Kavitha Illath Moeto Nagai Fan-Gang Tseng Tuhin Subhra Santra Source Type: research
Dopaminergic neuroprotective effects of inosine in MPTP-induced parkinsonian mice via brain-derived neurotrophic factor upregulation
Neuropharmacology. 2023 Jul 6:109652. doi: 10.1016/j.neuropharm.2023.109652. Online ahead of print.ABSTRACTParkinson's disease (PD) is the second most common neurodegenerative disease. However, no curative or modifying therapy is known. Inosine is a purine nucleoside that increases brain-derived neurotrophic factor (BDNF) expression in the brain through adenosine receptors. Herein, we investigated the neuroprotective effects of inosine and elucidated the mechanisms underlying its pharmacological action. Inosine rescued SH-SY5Y neuroblastoma cells from MPP+ injury in a dose-dependent manner. Inosine protection correlated wi...
Source: Neuropharmacology - July 8, 2023 Category: Drugs & Pharmacology Authors: Shristi Khanal Eugene Bok Jaekwang Kim Gyu Hwan Park Dong-Young Choi Source Type: research
Activation of the mTOR pathway promotes neurite growth through upregulation of CD44 expression
CONCLUSION: Activation of the mTOR pathway promoted neurite growth through upregulation of CD44 expression, thus promoting neuronal regeneration.PMID:37340717 | DOI:10.1177/03000605231178510
Source: Cell Research - June 21, 2023 Category: Cytology Authors: Jiwei Zhang Wenjuan Gan Ru Peng Lei Lu Weiqing Lu Jiamei Liu Source Type: research
Neuroprotective effect of dexmedetomidine pretreatment on sevoflurane-initiated neurotoxicity via the miR-204-5p/SOX4 axis
CONCLUSION: Dex pretreatment decreased miR-204-5p expression levels and upregulated SOX4 expression levels, palliating Sev-initiated neurotoxicity.PMID:37259215 | DOI:10.2174/0929866530666230530164913
Source: Protein and Peptide Letters - June 1, 2023 Category: Biochemistry Authors: Run Wang Pengfei Liu Fan Li Hui Qiao Source Type: research
LincRNA-p21 Promotes Cellular Senescence by Down-regulating the Wnt/ β-catenin Pathway in MPP+-treated SH-SY5Y Cells
CONCLUSION: Our study showed that in the treatment of MPP+, lincRNA-p21 might serve a role in the SH-SY5Y cell senescence by modulating the Wnt/β-catenin pathway, as well as increasing oxidant stress. Thus, trying to target lincRNA-p21 may have important therapeutic and practical implications for PD.PMID:37073660 | DOI:10.2174/1386207326666230417103137
Source: Combinatorial Chemistry and High Throughput Screening - April 19, 2023 Category: Chemistry Authors: Jianyu Zhu Lingli Chen Source Type: research
GSE161899 The dependency factor RRM2 at the nexus of a copy number driven regulatory network and a target for synthetic lethal interactions with replication stress checkpoint addiction in high-risk neuroblastoma siRNA_RRM2
In this study, we identified and functionally evaluated the ‘ribonucleotide reductase regulatory subunit 2’ (RRM2) as a top-ranked 2p putative co-driver and therapeutic target in high-risk neuroblastoma enforcing replicative stress resistance. RRM2 dependency was shown in vitro through knockdown in neuroblastoma cells, with transcriptome analysis reveali ng downregulation of pediatric tumor markers. Transgenic zebrafish lines expressing RRM2 in immature sympathoblasts were crossed with a dh-MYCN transgenic zebrafish line, with RRM2 overexpression dramatically increasing tumor penetrance from 20% to nearly 100%, acce...
Source: GEO: Gene Expression Omnibus - August 3, 2022 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
BCL11A Facilitates Cell Proliferation and Metastasis in Neuroblastoma via Regulating the PI3K/Akt Signaling Pathway
CONCLUSION: As a prognostic indicator of survival in NB patients, BCL11A might serve as a potential therapeutic target. BCL11A played a regulatory role in cell proliferation, invasion and migration in NB,which may be through the PI3K/AKT signaling pathway and induce EMT.PMID:35909289 | DOI:10.2174/1568009622666220728123748
Source: Current Cancer Drug Targets - August 1, 2022 Category: Cancer & Oncology Authors: Qianya Jin Yanmin Chen Shibei Du Dongqing Xu Juanqing Yue Lei Cai Xiaojun Yuan Source Type: research
