LincRNA-p21 Promotes Cellular Senescence by Down-regulating the Wnt/ β-catenin Pathway in MPP+-treated SH-SY5Y Cells

CONCLUSION: Our study showed that in the treatment of MPP+, lincRNA-p21 might serve a role in the SH-SY5Y cell senescence by modulating the Wnt/β-catenin pathway, as well as increasing oxidant stress. Thus, trying to target lincRNA-p21 may have important therapeutic and practical implications for PD.PMID:37073660 | DOI:10.2174/1386207326666230417103137
Source: Combinatorial Chemistry and High Throughput Screening - Category: Chemistry Authors: Source Type: research