Filtered By:
Specialty: Biochemistry
Cancer: Lung Cancer
This page shows you your search results in order of date.
Order by Relevance | Date
Total 78 results found since Jan 2013.
LncRNA AP000695.2 promotes glycolysis of lung adenocarcinoma via the miR-335-3p/TEAD1 axis
This study aims to verify and explore the mechanism of AP000695.2 in glycolysis of LUAD. Overexpression plasmid and siRNA are used to construct cell models of upregulation and downregulation of AP000695.2, respectively. AP000695.2 is highly expressed in lung cancer cell lines as revealed by qPCR. Western blot analysis, FDG uptake, lactate production assay and ECAR determination results show that high expression of AP000695.2 facilitates glycolysis of LUAD cells. CCK-8, EdU staining, Transwell and wound healing assays show that high expression of AP000695.2 promotes cell growth and migration of LUAD. The relationship betwee...
Source: Acta Biochimica et Biophysica Sinica - September 19, 2023 Category: Biochemistry Authors: Shuoyan Xu Zhiming Cheng Bulin Du Yao Diao Yaming Li Xuena Li Source Type: research
Targeting Pokemon is a novel strategy to suppress cancer aggressiveness of non-small cell lung cancer: Identification of Pokemon as ideal target for developing anti-NSCLC drugs
Arch Biochem Biophys. 2023 May 12:109637. doi: 10.1016/j.abb.2023.109637. Online ahead of print.ABSTRACTAlthough it is widely reported that Pokemon acts as an oncogene in the pathogenesis of multiple cancers, but its role and detailed molecular mechanisms in regulating non-small cell lung cancer (NSCLC) progression have not been fully delineated. Here, by performing Real-Time qPCR analysis, we verified that Pokemon was high-expressed in NSCLC tissues and cells, compared to the corresponding normal lung tissues and epithelial cells. Then, the small interfering RNA (siRNA) for Pokemon was transfected into the NSCLC cells to ...
Source: Archives of Biochemistry and Biophysics - May 14, 2023 Category: Biochemistry Authors: Hao Chang Wenxue Sun Yiming Zhao Tianhao Sun Zhihong Zhao Source Type: research
Nimbolide Exhibits Potent Anticancer Activity Through ROS-Mediated ER Stress and DNA Damage in Human Non-small Cell Lung Cancer Cells
Appl Biochem Biotechnol. 2023 Apr 27. doi: 10.1007/s12010-023-04507-9. Online ahead of print.ABSTRACTThe non-small cell lung cancer (NSCLC) accounts for about 85% of all lung cancers. It is usually diagnosed at an advanced stage with poor prognosis. Nimbolide (NB), a terpenoid limonoid isolated from the flowers and leaves of neem tree, possesses anticancer properties in various cancer cell lines. However, the underlying mechanism of its anticancer effect on human NSCLC cells remains unclear. In the present study, we investigated the effect of NB on A549 human NSCLC cells. We found that NB treatment inhibits A549 cells colo...
Source: Applied Biochemistry and Biotechnology - April 27, 2023 Category: Biochemistry Authors: Xi Chen Hangshuo Zhang Yuzhu Pan Ning Zhu Lisha Zhou Guang Chen Jiabing Wang Source Type: research
Targeting Rab26 to Conquer Cisplatin-Resistant Lung Cancer with Self-Assembled DNA Nanomaterials
In this study, we developed a nanosystem based on programmed DNA self-assembly of Rab26 siRNA-loaded nanoparticles (siRNP). We demonstrated that siRNP could be effectively transfected into cisplatin-resistant A549 (A549/DDP) cells. These siRab26-carrying nanoparticles induced apoptosis and inhibited the disruption of autophagy. The combination therapy of siRab26 knockdown with cisplatin could improve the antitumor therapy compared with a single one in vitro. In nude mice, siRNP enhanced the chemosensitivity of cisplatin-resistant cells and inhibited tumor xenograft development. These outcomes suggest that siRNP is an effec...
Source: Biomacromolecules - April 3, 2023 Category: Biochemistry Authors: Beinuo Wang Ruijie Zhang Yao Wang Hang Qian Di Wu Binfeng He Hu Liao Source Type: research
The interaction of CFLAR with p130Cas promotes cell migration
Biochim Biophys Acta Mol Cell Res. 2022 Nov 15:119390. doi: 10.1016/j.bbamcr.2022.119390. Online ahead of print.ABSTRACTCASP8 and FADD Like Apoptosis Regulator (CFLAR) is a key anti-apoptotic regulator for resistance to apoptosis mediated by Fas and TRAIL. In addition to its anti-apoptotic function, CFLAR is also an important mediator of tumor growth. High level of CFLAR expression correlates with a more aggressive tumor. However, the mechanism of CFLAR signaling in malignant progression is not clear. Here we report a novel CFLAR-associated protein p130Cas, which is a general regulator of cell growth and cell migration. CF...
Source: Biochimica et Biophysica Acta - November 18, 2022 Category: Biochemistry Authors: Hao Li Luqi Li Xun Qiu Jing Zhang Zichun Hua Source Type: research
Autophagy regulates transforming growth factor β signaling and receptor trafficking
Biochim Biophys Acta Mol Cell Res. 2022 May 20:119284. doi: 10.1016/j.bbamcr.2022.119284. Online ahead of print.ABSTRACTTransforming growth factor beta (TGFβ) stimulates tumorigenesis by inducing epithelial to mesenchymal transition (EMT) and cell migration. TGFβ signaling is regulated by the endocytosis of cell surface receptors and their subcellular trafficking into the endo-lysosomal system. Here we investigated how autophagy, a cellular quality control network that delivers material to lysosomes, regulates TGFβ signaling pathways that induce EMT and cell migration. We impaired autophagy in non-small cell lung cancer...
Source: Biochimica et Biophysica Acta - May 23, 2022 Category: Biochemistry Authors: Charles B Trelford Gianni M Di Guglielmo Source Type: research
Prof. Transient receptor potential vanilloid 4 promotes the growth of non-small cell lung cancer by regulating Foxp3
CONCLUSIONS: Antitumor effects caused by TRPV4 inhibition in NSCLC might be attributed to the suppression of Foxp3 which induced subsequent cell apoptosis. Thus, pharmacological inhibition of TRPV4 may be a promising option for NSCLC treatment.PMID:34995050 | DOI:10.18388/abp.2020_5614
Source: Acta Biochim Pol - January 7, 2022 Category: Biochemistry Authors: Jiang-Tao Pu Tao Zhang Kai-Ming He Deng-Guo Zhang Zhang-Yu Teng Yun-Fei Wu Source Type: research
