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Specialty: Cytology
Cancer: Lung Cancer
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Total 82 results found since Jan 2013.
Escin enhanced the efficacy of sorafenib by autophagy-mediated apoptosis in lung cancer cells
In this study, therapeutic potential of escin in combination with sorafenib has been explored. 3-(4,5-Dimethylthiazol-2-yl)-2 5-diphenyltetrazolium bromide assay was used to calculate IC50 values. The synergy was evaluated using Chou-Talaly algorithm. Cellular reactive oxygen species, mitochondrial membrane potential, annexin V, and cell-cycle studies were done by flow-cytometer, and autophagy biomarkers expression were determined using western blotting. Moreover, autophagy was knocked down using ATG5 siRNA to confirm its role, diethylnitrosamine-induced lung cancer model was used to check the synergy of sorafenib/escin. E...
Source: Cell Research - July 19, 2023 Category: Cytology Authors: Yusuf Hussain Jyoti Singh Abha Meena Rohit Anthony Sinha Suaib Luqman Source Type: research
The combination of osimertinib with Raf inhibitor overcomes osimertinib resistance induced by KRAS amplification in EGFR-mutated lung cancer cells
Exp Cell Res. 2023 Jul 11:113722. doi: 10.1016/j.yexcr.2023.113722. Online ahead of print.ABSTRACTOsimertinib is a third-generation epidermal growth factor receptor (EGFR)1 tyrosine kinase inhibitor (TKI) approved for the treatment of EGFR-positive patients exhibiting a T790 M resistance mutation after treatment with an earlier generation of EGFR TKIs. However, resistance to osimertinib inevitably develops despite its efficacy, and the resistance mechanisms are complex and not fully understood. We established cell lines with acquired resistance to osimertinib from gefitinib- or erlotinib-resistant NSCLC cells using a dose-...
Source: Experimental Cell Research - July 13, 2023 Category: Cytology Authors: Tae-Gul Lee Hye-Min Kang Seo Yun Kim Hye-Ryoun Kim Cheol Hyeon Kim Source Type: research
Harmine loaded Au@MSNs@PEG@Asp6 nano-composites for treatment of spinal metastasis from lung adenocarcinoma by targeting ANXA9 < em > in vivo < /em > experiment
CONCLUSIONS: ANXA9 may serve as a novel biomarker for predicting poor prognosis in LUAD, and we provided an efficient and targeting drug delivery nano-composites system for precise treatment of SM from LUAD.PMID:37323183 | PMC:PMC10261857 | DOI:10.21037/tlcr-23-191
Source: Cell Research - June 16, 2023 Category: Cytology Authors: Houlei Wang Fancheng Chen Annan Hu Haifeng Liang Yun Liang Nagashree Seetharamu Huiren Wang Jian Dong Source Type: research
Convergence of YAP/TAZ, TEAD and TP63 activity is associated with bronchial premalignant severity and progression
CONCLUSIONS: Our study identifies important gene regulatory functions for YAP/TAZ-TEAD-TP63 in the early stages of lung cancer development, which notably includes immune-suppressive roles, and suggest that an assessment of the activity of this transcriptional complex may offer a means to identify immune evasive bronchial PMLs and serve as a potential therapeutic target.PMID:37150829 | DOI:10.1186/s13046-023-02674-5
Source: Cell Research - May 7, 2023 Category: Cytology Authors: Boting Ning Andrew M Tilston-Lunel Justice Simonetti Julia Hicks-Berthet Adeline Matschulat Roxana Pfefferkorn Avrum Spira Matthew Edwards Sarah Mazzilli Marc E Lenburg Jennifer E Beane Xaralabos Varelas Source Type: research
S100A8/A9-RAGE pathway and chronic airway inflammation in smoke-induced lung carcinogenesis
ConclusionOur study suggests that the S100A8/A9-RAGE signal pathway is the mainstream of the inflammation-immune response induced in cancer progression in CSE-related smoke-induced lung carcinogenesis in vitro and in vivo. Further studies are needed to identify the therapeutic targets of cigarette smoke-induced inflammation and immunosuppression in the tumor microenvironment.
Source: Molecular and Cellular Toxicology - March 15, 2023 Category: Cytology Source Type: research
FOXA2 and STAT5A regulate oncogenic activity of KIF5B-RET fusion
Am J Cancer Res. 2023 Feb 15;13(2):638-653. eCollection 2023.ABSTRACTKIF5B-RET gene rearrangement occurs in ~1% of lung adenocarcinomas. Recently, targeted agents that inhibit RET phosphorylation have been evaluated in several clinical studies; however, little is known about the role of this gene fusion in driving lung cancer. Immunohistochemistry was used to evaluate the expression of the FOXA2 protein in tumor tissues of patients with lung adenocarcinoma. KIF5B-RET fusion cells proliferated in a cohesive form and grew tightly packed with variable-sized colonies. The expression of RET and its downstream signaling molecule...
Source: Cell Research - March 10, 2023 Category: Cytology Authors: Mi-Ran Lee Jung-Young Shin Min-Young Kim Jeong-Oh Kim Chan Kwon Jung Jinhyoung Kang Source Type: research
MLL4 Regulates the Progression of Non-Small-Cell Lung Cancer by Regulating the PI3K/AKT/SOX2 Axis
CONCLUSION: Our findings identify an important role of MLL4 in lung carcinogenesis through transcriptional regulation of PIK3IP1, affecting the PI3K/AKT/SOX2 axis, and suggest that MLL4 could be a potential prognostic indicator and target for non-small cell lung cancer therapy.PMID:36701842 | DOI:10.4143/crt.2022.1042
Source: Cell Research - January 26, 2023 Category: Cytology Authors: Yang Yang Rongfang Qiu Qiaoyou Weng Ziwei Xu Jingjing Song Siyu Zhao Miaomiao Meng Dengke Zhang Chunli Kong Hailin Wang Min Xu Zhongwei Zhao Jiansong Ji Source Type: research
The interaction of CFLAR with p130Cas promotes cell migration
Biochim Biophys Acta Mol Cell Res. 2022 Nov 15:119390. doi: 10.1016/j.bbamcr.2022.119390. Online ahead of print.ABSTRACTCASP8 and FADD Like Apoptosis Regulator (CFLAR) is a key anti-apoptotic regulator for resistance to apoptosis mediated by Fas and TRAIL. In addition to its anti-apoptotic function, CFLAR is also an important mediator of tumor growth. High level of CFLAR expression correlates with a more aggressive tumor. However, the mechanism of CFLAR signaling in malignant progression is not clear. Here we report a novel CFLAR-associated protein p130Cas, which is a general regulator of cell growth and cell migration. CF...
Source: Cell Research - November 18, 2022 Category: Cytology Authors: Hao Li Luqi Li Xun Qiu Jing Zhang Zichun Hua Source Type: research
Long non-coding RNA LUCAT1 regulates the RAS pathway to promote the proliferation and invasion of malignant glioma cells through ABCB1
In this study, the role of lung cancer associated transcript 1 (lncRNA LUCAT 1) in glioma occurrence and development, as well as its possible regulatory mechanism, was explored. We utilized the gene chip technology in the preliminary experiment, and based on the experiment results, selected LUCAT1（NONHSAT102745）, which was significantly upregulated in glioma, and ATP-binding cassette Subfamily B member l (ABCB1), which was significantly down-regulated in co-expression analysis, for study. Next, the expression of LUCAT1 and ABCB1 in cells and tissues was immediately evaluated. Subsequently, the cells were transfected wi...
Source: Cell Research - October 21, 2022 Category: Cytology Authors: Xia Wu Lvmeng Song Xiangrong Chen Yalan Zhang Shun Li Xiaoping Tang Source Type: research
