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Enhanced expression of Pentraxin-3 in glioblastoma cells correlates with increased invasion and IL8-VEGF signaling axis
In this study, we examined the role of PTX3 in GB growth, angiogenesis, and invasion using in vitro and in vivo GB models, proteomic profiling, molecular and biochemical approaches. Under in vitro conditions, PTX3 over-expression in U87 cells correlated with cell cycle progression, increased migratory potential, and proliferation under hypoxic conditions. Conditioned media containing PTX3 enhanced the angiogenic potential of endothelial cells. While silencing of PTX3 by siRNA decreased the proliferation, migration, and angiogenic potential of U87 cells in vitro. Importantly, PTX3 over-expression increased tumor growth, ang...
Source: Brain Research - December 15, 2021 Category: Neurology Authors: Umadevi V Wesley Ian Sutton Paul A Clark Katelin Cunningham Carolina Larrain John S Kuo Robert J Dempsey Source Type: research

MALAT1 Improves Functional Recovery after Traumatic Brain Injury through Promoting Angiogenesis in Experimental Mice
Brain Res. 2021 Nov 19:147731. doi: 10.1016/j.brainres.2021.147731. Online ahead of print.ABSTRACTAs a highly evolutionary conserved lncRNA, MALAT1 was first demonstrated to associate with metastasis of lung tumor by promoting angiogenesis. Activated vasculature was recently indicated to assist neurogenesis by secreting neurotrophic factor Ang1 (Angiopoietin-1). The purpose of this study is to investigate the potential role of MALAT1 in angiogenesis following traumatic brain injury (TBI). Adult male mice were subjected to controlled cortical impact (CCI) and brain microvacular endothelial cells were exposed to oxygen-gluco...
Source: Brain Research - November 22, 2021 Category: Neurology Authors: Han Liu Zhaosheng Wei Xiaochuan Sun Zhigang Wang Source Type: research

LINC00511 knockdown suppresses glioma cell malignant progression through miR-15a-5p/AEBP1 axis
CONCLUSION: LINC00511 knockdown inhibits glioma cell progression via miR-15a-5p/AEBP1 axis.PMID:33992709 | DOI:10.1016/j.brainresbull.2021.05.010
Source: Brain Research - May 16, 2021 Category: Neurology Authors: Zhen Liu Bei Tao Linkun Li Pin Liu Kaiguo Xia Chuanhong Zhong Source Type: research

Effect of Ras-guanine nucleotide release factor 1-mediated H-Ras/ERK signaling pathway on glioma.
CONCLUSION: Ras-GRF1 was upregulated in glioma tissues and correlated with its malignancy and prognosis. Silencing Ras-GRF1, through mediating H-Ras/ERK pathway, may suppress the growth and metastasis of glioma. PMID: 33412149 [PubMed - as supplied by publisher]
Source: Brain Research - January 4, 2021 Category: Neurology Authors: Pan YH, Chen J, Sun C, Ma JF, Li X Tags: Brain Res Source Type: research

Clinacanthus nutans Mitigates Neuronal Death and Reduces Ischemic Brain Injury: Role of NF- κB-driven IL-1β Transcription
AbstractNeuroinflammation has been shown to exacerbate ischemic brain injury, and is considered as a prime target for the development of stroke therapies.Clinacanthus nutans Lindau (C. nutans) is widely used in traditional medicine for treating insect bites, viral infection and cancer, due largely to its anti-oxidative and anti-inflammatory properties. Recently, we reported that an ethanol extract from the leaf ofC. nutans could protect the brain against ischemia-triggered neuronal death and infarction. In order to further understand the molecular mechanism(s) for its beneficial effects, two experimental paradigms, namely,...
Source: NeuroMolecular Medicine - October 5, 2020 Category: Neurology Source Type: research

LncRNA SNHG7 sponges miR-449a to promote pituitary adenomas progression
This study aimed to characterize the expression status and potentially mechanistic involvement of SNHG7 in pituitary adenoma. Relative expression of SNHG7 and miR-449a was analyzed by real-time PCR. Cell viability was measured with Cell Counting Kit-8 (CCK-8). Cell apoptosis was determined by PI/Annexin V double staining followed by flow cytometry analysis. Cell invasion and migration were analyzed by wound healing and transwell assays, respectively. The regulatory action of miR-449a on SNHG7 was interrogated by luciferase reporter assay. We also investigated the pro-tumor activity of SNHG7 with the MMQ xenograft tumor mou...
Source: Metabolic Brain Disease - September 2, 2020 Category: Neurology Source Type: research

Mixed Lineage Leukemia 1 Promoted Neuron Apoptosis in Ischemic Penumbra via Regulating ASK-1/TNF- α Complex
This study aimed to explore the underlying mechanism of neuron apoptosis in ischemic penumbra via histone methyltransferase (HMT) mixed lineage leukemia 1 (MLL1) mediated epigenetic pathway. Mouse IS model was established by middle cerebral artery occlusion (MCAO). Mouse primary cortical mixed cells were cultured and treated with oxygen–glucose deprivation (OGD) to simulate IS process. The expressions of apoptosis signal regulating kinase-1 (ASK-1), pASK-1, cleaved caspase-3, ASK-1/serine–threonine kinase receptor-associated protein (STRAP)/14-3-3 complex, ASK-1/tumor necrosis factor-α (TNF-α) complex, and MLL1 in mo...
Source: Frontiers in Neuroanatomy - July 24, 2020 Category: Neurology Source Type: research

lncRNA Mtss1 promotes inflammatory responses and secondary brain injury after intracerebral hemorrhage by targeting miR-709 in mice.
Abstract Secondary brain injuries following intracerebral hemorrhage (ICH) are mediated by inflammatory pathway activation. The present study aimed to characterize long noncoding RNAs (lncRNAs) that are differentially expressed in cerebral tissues during ICH pathogenesis and to investigate their pathogenic functions. An ICH mouse model established by collagenase injection was used to obtain differentially expressed lncRNAs for deep sequencing. A cellular inflammation model was established by treating mouse microglia with lipopolysaccharide. Expression of lncRNA and miRNA was assessed by quantitative RT-PCR, and pr...
Source: Brain Research Bulletin - May 18, 2020 Category: Neurology Authors: Chen JX, Wang YP, Zhang X, Li GX, Zheng K, Duan CZ Tags: Brain Res Bull Source Type: research

GAS5 knockdown ameliorates apoptosis and inflammatory response by modulating miR-26b-5p/Smad1 axis in cerebral ischaemia/reperfusion injury.
This study established a CI / R injury model in vivo and in vitro. The results showed that the expression of GAS5 was increased in CI / R rats, while miR-26b-5p expression was decreased. Besides, knockdown of GAS5 by siRNA (si-GAS5) reversed CI / R-induced apoptosis and inflammatory responses. Notably, bioinformatics analysis indicated that GAS5 competitively adsorbed miR-26b-5p, and the relationship was further confirmed by pull-down assay. In addition, miR-26b-5p overexpression reversed CI / R-induced apoptosis and inflammatory responses, whereas low expression of miR-26b-5p had the opposite effect. Moreover, TargetScan ...
Source: Behavioural Brain Research - November 17, 2019 Category: Neurology Authors: Shangguan Y, Han J, Su H Tags: Behav Brain Res Source Type: research

Analgesic effect of resveratrol on colitis-induced visceral pain via inhibition of TRAF6/NF- κB signaling pathway in the spinal cord.
In conclusion, our results suggest that RSV exerts the effects of antinociception on colitis-induced visceral hyperalgesia through inhibition of spinal TRAF6/NF-κB signaling pathway and the production of inflammatory mediators in the spinal cord, suggesting a new application of RSV for the treatment of visceral pain. PMID: 31536729 [PubMed - as supplied by publisher]
Source: Brain Research - September 15, 2019 Category: Neurology Authors: Lu Y, Xu HM, Han Y, Zhang YL Tags: Brain Res Source Type: research

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