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Cancer: Osteosarcoma

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Total 17 results found since Jan 2013.

ZBTB7C m6A modification incurred by METTL3 aberration promotes osteosarcoma progression
Aberrant N6-methyladenosine (m6A) modification of mRNAs contributes significantly to the epigenetic tumorigenesis, however, its precise role and the key targets in osteosarcoma (OS) are not defined. Here we reported that selective METTL3 (methyltransferase like 3) elevation and the consequential increase of m6A modification causally affect OS progression. The fast-growing OS cells displayed preferential upregulation of METTL3 and increased m6A modification. Conversely, m6A inhibition by 3-deazaadenosine, siRNA-mediated METTL3 knockdown or a METTL3-selective inhibitor by STM2457 effectively inhibits OS cell growth and induc...
Source: Translational Research - April 28, 2023 Category: Research Authors: Xueying An, Wenshu Wu, Lin Yang, Jian Dong, Bin Liu, Junxia Guo, Jianmei Chen, Baosheng Guo, Wangsen Cao, Qing Jiang Source Type: research

Cancer combination therapies by silencing of CTLA ‐4, PD‐L1, and TIM3 in osteosarcoma
ConclusionOur findings suggest that triple blockade of CTLA-4, PD-L1, and TIM3 is an effective strategy for inhibiting tumor cell progression and migration in OS, which requires large-scale clinical investigations to be translated into broad therapeutic applicability for OS patients.
Source: IUBMB Life - May 31, 2022 Category: Research Authors: Amin Daei Sorkhabi, Aila Sarkesh, Ali Fotouhi, Hossein Saeedi, Leili Aghebati ‐Maleki Tags: RESEARCH COMMUNICATION Source Type: research

Receptor Tyrosine Kinases in Osteosarcoma: 2019 Update.
Authors: Greenfield EM, Collier CD, Getty PJ Abstract The primary conclusions of our 2014 contribution to this series were as follows: Multiple receptor tyrosine kinases (RTKs) likely contribute to aggressive phenotypes in osteosarcoma and, therefore, inhibition of multiple RTKs is likely necessary for successful clinical outcomes. Inhibition of multiple RTKs may also be useful to overcome resistance to inhibitors of individual RTKs as well as resistance to conventional chemotherapies. Different combinations of RTKs are likely important in individual patients. AXL, EPHB2, FGFR2, IGF1R, and RET were identified as pr...
Source: Advances in Experimental Medicine and Biology - August 13, 2020 Category: Research Tags: Adv Exp Med Biol Source Type: research

The Effects of Interleukin-33 (IL-33) on Osteosarcoma Cell Viability, Apoptosis, and Epithelial-Mesenchymal Transition are Mediated Through the PI3K/AKT Pathway.
CONCLUSIONS IL-33 was highly expressed in human osteosarcoma cells. Down-regulation of IL-33 reduced cell viability and EMT of osteosarcoma cells, and induced cell apoptosis through activation of the PI3K/AKT signaling pathway. PMID: 32312946 [PubMed - in process]
Source: Medical Science Monitor - April 23, 2020 Category: Research Tags: Med Sci Monit Source Type: research

Orai1 Promotes Osteosarcoma Metastasis by Activating the Ras-Rac1-WAVE2 Signaling Pathway.
CONCLUSIONS Orai1 activates the Ras-Rac1-WAVE2 signaling pathway to promote metastasis of osteosarcoma. Abnormal expression or function of Orai1 may be an important cause of osteosarcoma metastasis. PMID: 31796725 [PubMed - in process]
Source: Medical Science Monitor - December 7, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Long noncoding RNA NORAD regulates cancer cell proliferation and migration in human osteosarcoma by endogenously competing with miR ‐199a‐3p
In this study, we evaluated the expressions and functions of a long noncoding RNA (lncRNA), Noncoding RNA activated by DNA damage (NORAD) in human osteosarcoma. NORAD expressions were evaluated by qRT ‐PCR in in vitro osteosarcoma cell lines and in vivo clinical specimens. SiRNA‐induced NORAD downregulation was conducted in Saos‐2 and 143B cells, and the functional effects of NORAD downregulation on osteosarcoma cells were evaluated by CCK‐8 proliferation assay, 24‐well transwell invasi on assay and in vivo tumor explant assay, respectively. The possibility of NORAD endogenously competing microRNA target, hsa‐m...
Source: IUBMB Life - June 5, 2019 Category: Research Authors: Xuming Wang, Jilong Zou, Hongjun Chen, Peng Zhang, Zhiyuan Lu, Zhitao You, Jiabing Sun Tags: RESEARCH COMMUNICATION Source Type: research

Interleukin-22 Promotes Osteosarcoma Cell Proliferation and Invasion via STAT3 Activation.
CONCLUSIONS These results suggest that IL-22 promotes OS cells proliferation and invasion and its effect is mediated by activation of the STAT3 pathway. These findings demonstrate that IL-22 may serve as a promising molecular biomarker for diagnosis and therapy for OS patients. PMID: 30381753 [PubMed - in process]
Source: Medical Science Monitor - November 3, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Activation of Sonic Hedgehog Signaling Is Associated with Human Osteosarcoma Cells Radioresistance Characterized by Increased Proliferation, Migration, and Invasion.
CONCLUSIONS Activation of Shh signaling was involved in radioresistance of OS cells. Blocking this signaling can impair the radioresistance capacity of OS cells. PMID: 29864766 [PubMed - in process]
Source: Medical Science Monitor - June 6, 2018 Category: Research Tags: Med Sci Monit Source Type: research

Leptocarpin Suppresses Proliferation, Migration, and Invasion of Human Osteosarcoma by Targeting Type-1 Insulin-Like Growth Factor Receptor (IGF-1R).
CONCLUSIONS LTC suppressed osteosarcoma proliferation, migration, and invasion by inhibiting IGF-1R expression. IGF-1R is one of the targets in LTC suppressing osteosarcoma. PMID: 28844074 [PubMed - in process]
Source: Medical Science Monitor - August 29, 2017 Category: Research Tags: Med Sci Monit Source Type: research

Effects of long non-coding RNA SPRY4-IT1 on osteosarcoma cell biological behavior.
In conclusion, these data suggest that SPRY4-IT1 could be an oncogene for OS, and may be served as a candidate target for new therapies in human OS. PMID: 28078006 [PubMed]
Source: American Journal of Translational Research - January 13, 2017 Category: Research Tags: Am J Transl Res Source Type: research

LDHB may be a significant predictor of poor prognosis in osteosarcoma.
Authors: Li C, Chen Y, Bai P, Wang J, Liu Z, Wang T, Cai Q Abstract Osteosarcoma is the most common primary malignant bone tumor in children and young adults. Lactate dehydrogenase (LDH) is considered as the key glycolytic enzyme and involved in tumor initiation and metabolism. Here, we firstly found that LDHB was highly expressed in osteosarcoma cell lines. Expression profiling indicated that LDHB mRNA was elevated in osteosarcoma tissues with metastasis versus without metastasis, and LDHB high expression predicted a poor prognosis in patients. After LDHB knockdown by siRNA transfection, cell growth and proliferat...
Source: American Journal of Translational Research - December 3, 2016 Category: Research Tags: Am J Transl Res Source Type: research

Down-Regulation of MicroRNA-133b Suppresses Apoptosis of Lens Epithelial Cell by Up-Regulating BCL2L2 in Age-Related Cataracts.
CONCLUSIONS BCL2L2 was the virtual target of miR-133b, and we found a negative regulatory relationship between miR-133b and BCL2L2. MiR-133b and BCL2L2 interfered with the viability and apoptosis of cells. PMID: 27802259 [PubMed - in process]
Source: Medical Science Monitor - November 2, 2016 Category: Research Tags: Med Sci Monit Source Type: research

Expression of G Protein-coupled Receptor 56 Is an Unfavorable Prognostic Factor in Osteosarcoma Patients.
This study aimed at figuring out whether expression of the GPR56 was associated with clinicopathological features of osteosarcoma. Eighty-nine patients who received osteosarcoma operation between March 2004 and February 2011 in Linyi People's Hospital were recruited. Immunohistochemical staining (IHC) was carried out to identify the expression of GPR56 in those osteosarcoma tissues, and our cohort was divided into higher-expression group and lower-expression group according to the cut-off of IHC score. Expression of GPR56 in osteosarcoma tissues was correlated with the TNM stage and overall survival. Univariate and multiva...
Source: The Tohoku Journal of Experimental Medicine - July 13, 2016 Category: Research Authors: Chen Z, Gao P, Li Z Tags: Tohoku J Exp Med Source Type: research