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Knockdown of LIMD2 inhibits the progression of ovarian carcinoma through ERK1/2 pathway
CONCLUSION: Knockdown of LIMD2 inhibits cell proliferation, migration, invasion and autophagy, and promotes the apoptosis through the ERK1/2 signaling pathway, suggesting that LIMD2-siRNA may be an effective molecule to prevent OC progression.PMID:37716918 | DOI:10.1007/s11033-023-08733-6
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Haiyang Hu Yanan Wang Yan Dong Lin Wang Yahui Chen Yan Zhou Lin Sun Source Type: research

Environmental-relevant bisphenol A exposure promotes ovarian cancer stemness by regulating microRNA biogenesis
J Cell Mol Med. 2023 Aug 23. doi: 10.1111/jcmm.17920. Online ahead of print.ABSTRACTBisphenol A (BPA) is a ubiquitous environmental xenobiotic impacting millions of people worldwide. BPA has long been proposed to promote ovarian carcinogenesis, but the detrimental mechanistic target remains unclear. Cancer stem cells (CSCs) are considered as the trigger of tumour initiation and progression. Here, we show for the first time that nanomolar (environmentally relevant) concentration of BPA can markedly increase the formation and expansion of ovarian CSCs concomitant. This effect is observed in both oestrogen receptor (ER)-posit...
Source: Molecular Medicine - August 23, 2023 Category: Molecular Biology Authors: Sophia S N Lam Zeyu Shi Carman K M Ip Chris K C Wong Alice S T Wong Source Type: research

Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell proliferation and migration
CONCLUSION: The depletion of eIF5AHyp by GC7 or eIF5A-targeting siRNA attenuated activation of the SIK2-p4EBP1 pathway. In that way, eIF5AHyp depletion reduces the migration, clonogenicity, and viability of ES2 ovarian cancer cells.PMID:37219665 | DOI:10.1007/s11033-023-08510-5
Source: Molecular Biology Reports - May 23, 2023 Category: Molecular Biology Authors: Grace Kelly Lee Hae-Yeong Kim Jong Hwan Park Source Type: research

NANOG regulates epithelial-mesenchymal transition via AMPK/mTOR signalling pathway in ovarian cancer SKOV-3 and A2780 cells
J Cell Mol Med. 2022 Sep 16. doi: 10.1111/jcmm.17557. Online ahead of print.ABSTRACTNANOG engages with tumour initiation and metastasis by regulating the epithelial-mesenchymal transition (EMT) in epithelial ovarian cancer (EOC). However, its role in association with pAMPKα, and its clinical significance in EOC have not been elucidated even though AMPK is known to degrade NANOG in various human cancers. Hence, we investigated the role of pAMPKα and its association with NANOG as potential prognostic biomarkers in EOC. Both NANOG and pAMPKα expression were significantly overexpressed in EOCs comparing nonadjacent normal e...
Source: J Cell Mol Med - September 17, 2022 Category: Molecular Biology Authors: Hee Yun Gwan Hee Han Julie Kim Joon-Yong Chung Jae-Hoon Kim Hanbyoul Cho Source Type: research

Melatonin Sensitizes OVCAR-3 Cells to Cisplatin through Suppression of PI3K/Akt Pathway
This study examined the effect of melatonin on oxidative stress, expression of pro-apoptotic protein, anti-apoptotic proteins, and the activity of the PI3K/Akt signaling pathway in the human ovarian cancer cell line (OVCAR3). OVCAR3 cells were treated with cisplatin, melatonin, cisplatin + melatonin, and siRNA Akt. Reactive oxygen species levels were assessed. The expression of the proteins was determined by Western blot. Melatonin administration significantly increased intracellular ROS generation, the cleavage of caspase 3 and decreased phosphorylation of Akt. Combination therapy of cisplatin and melatonin increases apop...
Source: Cellular and Molecular Biology - August 21, 2022 Category: Molecular Biology Authors: Sahar Baghal-Sadriforoush Morteza Bagheri Isa Abdi Rad Fattah Sotoodehnejadnematalahi Source Type: research

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