Inhibiting eukaryotic initiation factor 5A (eIF5A) hypusination attenuated activation of the SIK2 (salt-inducible kinase 2)-p4E-BP1 pathway involved in ovarian cancer cell proliferation and migration

CONCLUSION: The depletion of eIF5AHyp by GC7 or eIF5A-targeting siRNA attenuated activation of the SIK2-p4EBP1 pathway. In that way, eIF5AHyp depletion reduces the migration, clonogenicity, and viability of ES2 ovarian cancer cells.PMID:37219665 | DOI:10.1007/s11033-023-08510-5

Source: Molecular Biology Reports - May 23, 2023 Category: Molecular Biology Authors: Grace Kelly Lee Hae-Yeong Kim Jong Hwan Park Source Type: research