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Long Noncoding RNA RMRP Contributes to Paclitaxel Sensitivity of Ovarian Cancer by Regulating miR-580-3p/MICU1 Signaling
J Oncol. 2022 Jan 29;2022:8301941. doi: 10.1155/2022/8301941. eCollection 2022.ABSTRACTOvarian cancer is a prevalent female malignancy affecting the health and life of an increasing population of women around the world. Paclitaxel (PTX) resistance is a significant clinical problem in the treatment of ovarian cancer. However, the regulation mechanism of PTX resistance remains unclear. In this investigation, we reported an innovative function of the long noncoding RNA RMRP in promoting PTX resistance and glycolysis of ovarian cancer cells. We observed that RMRP was highly expressed in the ovarian cancer samples, in which the...
Source: Journal of Oncology - February 8, 2022 Category: Cancer & Oncology Authors: Lingling Li Saitian Zeng Liang Guo Ping Huang Jie Xi Jing Feng Qian Li Yanying Li Xiyun Xiao Ruixue Yan Jiyan Zhang Source Type: research

Calcium-doped mesoporous silica nanoparticles as a lysosomolytic nanocarrier for amine-free loading and cytosolic delivery of siRNA
Publication date: 25 January 2020Source: Journal of Industrial and Engineering Chemistry, Volume 81Author(s): Eunshil Choi, Dong-Kwon Lim, Sehoon KimAbstractFor efficacious gene therapeutics, cytosolic transport of the endocytosed siRNA is crucial, not to mention a non-toxic delivery carrier composition. In this paper, we report facile achievement of amine-free loading and lysosomolytic delivery of siRNA in an unconventional way by using calcium (Ca2+)-doped mesoporous silica nanoparticles (CMSNs) as a host material along with a pore-loaded endosomal disruptor, chloroquine (CQ). It is demonstrated that CMSNs are capable of...
Source: Journal of Industrial and Engineering Chemistry - November 16, 2019 Category: Chemistry Source Type: research

Gene Therapy Leaves a Vicious Cycle
Reena Goswami1, Gayatri Subramanian2, Liliya Silayeva1, Isabelle Newkirk1, Deborah Doctor1, Karan Chawla2, Saurabh Chattopadhyay2, Dhyan Chandra3, Nageswararao Chilukuri1 and Venkaiah Betapudi1,4* 1Neuroscience Branch, Research Division, United States Army Medical Research Institute of Chemical Defense, Aberdeen, MD, United States 2Department of Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Sciences, Toledo, OH, United States 3Roswell Park Comprehensive Cancer Center, Buffalo, NY, United States 4Department of Physiology and Biophysics, Case Western Reserve University, Clev...
Source: Frontiers in Oncology - April 23, 2019 Category: Cancer & Oncology Source Type: research

Complement C5b-9 and Cancer: Mechanisms of Cell Damage, Cancer Counteractions, and Approaches for Intervention
In conclusion, osmotic burst of inflated complement-damaged cells may occur, but these bursts are most likely a consequence of metabolic collapse of the cell rather than the cause of cell death. The Complement Cell Death Mediator: A Concerted Action of Toxic Moieties Membrane pores caused by complement were first visualized by electron microscopy on red blood cell membranes as large ring structures (22). Similar lesions were viewed on E. coli cell walls (23). Over the years, ample information on the fine ultrastructure of the MAC that can activate cell death has been gathered (24) and has been recently further examined (...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance
The molecular mechanism by which cancer-associated fibroblasts (CAFs) confer chemoresistance in ovarian cancer is poorly understood. The purpose of the present study was to evaluate the roles of CAFs in modulating tumor vasculature, chemoresistance, and disease progression. Here, we found that CAFs upregulated the lipoma-preferred partner (LPP) gene in microvascular endothelial cells (MECs) and that LPP expression levels in intratumoral MECs correlated with survival and chemoresistance in patients with ovarian cancer. Mechanistically, LPP increased focal adhesion and stress fiber formation to promote endothelial cell motil...
Source: Journal of Clinical Investigation - December 19, 2017 Category: Biomedical Science Authors: Cecilia S. Leung, Tsz-Lun Yeung, Kay-Pong Yip, Kwong-Kwok Wong, Samuel Y. Ho, Lingegowda S. Mangala, Anil K. Sood, Gabriel Lopez-Berestein, Jianting Sheng, Stephen T.C. Wong, Michael J. Birrer, Samuel C. Mok Source Type: research

Abstract 4111: The salt inducible kinase 2 (SIK2) links lipid metabolism to survival of ovarian cancer metastasis
Conclusion:Our results suggested that SIK2 phosphorylation and activation were required to establish ovarian cancer lesions at the adipocyte-rich omental environment. Therefore we suggest a therapeutic role for targeting SIK2 in preventing ovarian cancer metastases.Citation Format: Fabrizio Miranda, Shujuan Liu, Sandra Herrero-Gonzalez, David Mannion, Stefan Knapp, Ahmed A. Ahmed. The salt inducible kinase 2 (SIK2) links lipid metabolism to survival of ovarian cancer metastasis. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philade...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Miranda, F., Liu, S., Herrero-Gonzalez, S., Mannion, D., Knapp, S., Ahmed, A. A. Tags: Tumor Biology Source Type: research

Proteomic Delineation of Ovarian Cancer Cell Line Aggregates Genomics and Proteomics
Ovarian cancer is a lethal gynecological disease that is characterized by peritoneal metastasis and increased resistance to conventional chemotherapies. This increased resistance and the ability to spread is often attributed to the formation of multicellular aggregates or spheroids in the peritoneal cavity, which seed abdominal surfaces and organs. Given that the presence of metastatic implants is a predictor of poor survival, a better understanding of how spheroids form is critical to improving patient outcome, and may result in the identification of novel therapeutic targets. Thus, we attempted to gain insight into the p...
Source: Journal of Biological Chemistry - July 9, 2015 Category: Chemistry Authors: Musrap, N., Tuccitto, A., Karagiannis, G. S., Saraon, P., Batruch, I., Diamandis, E. P. Tags: Genomics and Proteomics Source Type: research

Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-x L strategies through Mcl-1 down-regulation
Abstract Ovarian carcinoma is the leading cause of death from gynecologic cancer in the developed world and is characterized by acquired chemoresistance leading to an overall 5-year survival rate of about 30 %. We previously showed that Bcl-xL and Mcl-1 cooperatively protect platinum-resistant ovarian cancer cells from apoptosis. Despite BH3-mimetics represent promising drugs to target Bcl-xL, anti-Mcl-1 strategies are still in pre-clinical studies and required new investigations. Calcium is a universal second messenger and dysregulation of calcium signal is often observed during carcinogenesis. As change in cyto...
Source: Apoptosis - January 27, 2015 Category: Molecular Biology Source Type: research

Novel Roles of Mitochondrial Uniporter in Ovarian Cancer Cell Biology
This study highlights the potential of nanomaterials as a tool to broaden our understanding of cellular processes, establishes MICU1 as a novel regulator of the machinery in cancer cells that prevents apoptosis, and emphasizes the need to synergize nanoparticle design with understanding of mitochondrial machinery for enhancing targeted cellular toxicity.
Source: Journal of Biological Chemistry - June 14, 2013 Category: Chemistry Authors: Arvizo, R. R., Moyano, D. F., Saha, S., Thompson, M. A., Bhattacharya, R., Rotello, V. M., Prakash, Y. S., Mukherjee, P. Tags: Signal Transduction Source Type: research