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Total 20 results found since Jan 2013.

Molecules, Vol. 28, Pages 97: Alpha Ketoglutarate Downregulates the Neutral Endopeptidase and Enhances the Growth Inhibitory Activity of Thiorphan in Highly Aggressive Osteosarcoma Cells
sińska Since natural substances are widely explored as epigenetic modulators of gene expression and epigenetic abnormalities are important causes of cancerogenesis, factors with pro-tumor activities subjected to epigenetic control, e.g., neutral endopeptidase (NEP, neprilysin), are promising anticancer targets for potential therapies acting via epigenetic regulation of gene expression. Alpha-ketoglutarate (AKG) is a naturally occurring co-substrate for enzymes involved in histone and DNA demethylation with suggested anti-cancer activity. Hence, we investigated a potential effect of AKG on the NEP expression in cells d...
Source: Molecules - December 22, 2022 Category: Chemistry Authors: Magdalena Mizerska-Kowalska Adrianna S ławińska-Brych Emilia Niedziela Viktor Brodovskiy Barbara Zdzisi ńska Tags: Article Source Type: research

LncRNA USP1 knockdown weakens the progression of colorectal cancer via modulating UBAP2L-Smad7-TGF- β pathway
CONCLUSION: Our data manifested that USP1 may serve as an oncogene in the tumorigenesis of CRC.PMID:35579161 | DOI:10.2174/1386207325666220509191309
Source: Combinatorial Chemistry and High Throughput Screening - May 17, 2022 Category: Chemistry Authors: Shi-Liang Tu Sheng Chen Shan Gao Quan-Jin Dong Zi-Ang Wan Rui Chai Source Type: research

Effects of long noncoding RNA AK093407 on the biological behavior of colon cancer cells and the underlying mechanism
CONCLUSION: These results showed that knockdown of AK093407 could inhibit colon cancer cell proliferation, induce apoptosis and cell cycle arrest, influence the expression of vital factors in mitochondrial apoptosis pathway and cell cycle regulatory pathway, and may negatively regulate JAK/STAT3 through down-regulating p-Stat3.PMID:35400339 | DOI:10.2174/1386207325666220408092028
Source: Combinatorial Chemistry and High Throughput Screening - April 11, 2022 Category: Chemistry Authors: Zhao Xuerong Sun Ao Wang Jianping Zheng Xin Tian Duoduo Wang Mingjuan Xiao Lijun Zhao Enhong Zheng-Guo Cui Source Type: research

PCSK9 as a new player in cancer: New opportunity or red herring?
Curr Med Chem. 2021 Nov 15. doi: 10.2174/0929867328666211115122324. Online ahead of print.ABSTRACTInitially described as a factor involved in liver regeneration and neuronal differentiation, proprotein convertase subtilisin/kexin type 9 (PCSK9) has become one of the key regulators of low-density lipoprotein cholesterol. Besides that, a number of studies have suggested PCSK9 may play a role in cancer biology. This is particularly true for gastroenteric (gastric and liver cancers) and lung cancers, where higher PCSK9 levels were associated with the increased ability of the tumor to develop and give metastasis as well as with...
Source: Current Medicinal Chemistry - November 16, 2021 Category: Chemistry Authors: Aldo Bonaventura Alessandra Vecchi é Massimiliano Ruscica Francesco Grossi Francesco Dentali Source Type: research

In silico and in vitro screening for potential anticancer candidates targeting GPR120.
In this study, a homology model of GPR120S (short isoform) was generated to identify potential anti-cancer compounds targeting the GPR120 receptor using a combined in silico docking-based virtual screening (DBVS), structure-activity relationships (SAR) and in vitro screening approach. SPECS database of synthetic chemical compounds (∼350,000) was screened using the developed GPR120S model to identify molecules binding to the orthosteric binding pocket followed by an AutoDock SMINA rigid-flexible docking protocol. The best 13 hit molecules were then tested in vitro to evaluate their cytotoxic activity against SW480 - human...
Source: Bioorganic and Medicinal Chemistry Letters - November 5, 2020 Category: Chemistry Authors: Pal A, Curtin JF, Kinsella GK Tags: Bioorg Med Chem Lett Source Type: research

The Application of the RNA Interference Technologies for KRAS: Current Status, Future Perspective and Associated Challenges.
Abstract KRAS is a member of the murine sarcoma virus oncogene-RAS gene family. It plays an important role in the prevention, diagnosis and treatment of tumors during tumor cell growth and angiogenesis. KRAS is the most commonly mutated oncogene in human cancers, such as the pancreatic cancers, colon cancers, and lung cancers. Detection of KRAS gene mutation is an important indicator for tracking the status of oncogenes, illuminating the developmental prognosis of various cancers, and the efficacy of radiotherapy and chemotherapy. However, the efficacy of different patients in clinical treatment is not the same. S...
Source: Current Topics in Medicinal Chemistry - August 27, 2019 Category: Chemistry Authors: Shao YT, Ma L, Zhang TH, Xu TR, Ye YC, Liu Y Tags: Curr Top Med Chem Source Type: research

SERPINA3 Silencing Inhibits the Migration, Invasion, and Liver Metastasis of Colon Cancer Cells.
CONCLUSION: SERPINA3 silencing could inhibit the migration, invasion, and liver metastasis of colon cancer cells. PMID: 29855767 [PubMed - as supplied by publisher]
Source: Anal Sci - May 31, 2018 Category: Chemistry Authors: Cao LL, Pei XF, Qiao X, Yu J, Ye H, Xi CL, Wang PY, Gong ZL Tags: Dig Dis Sci Source Type: research

Gossypol induces death receptor-5 through activation of ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL. Additions and Corrections
This article has been retracted by the publisher. An investigation at MD Anderson determined that image of control HCT116 cells treated with TRAIL and the image of cells transfected with CHOP siRNA and treated with TRAIL in Fig. 5C were reused. Additionally, the Journal determined that the actin immunoblot in Fig. 2A was reused as the actin immunoblot in Fig. 3B; the control/TRAIL treated image had been reused in the DR5/Gossypol+TRAIL and in the scrambled siRNA/TRAIL images in Fig. 4B; the scrambled siRNA/Gossypol image from Fig. 4B was reused as the NAC image in Fig. 7C; and the control/Gossypol image was reused as the C...
Source: Journal of Biological Chemistry - August 4, 2016 Category: Chemistry Authors: Sung, B., Ravindran, J., Prasad, S., Pandey, M. K., Aggarwal, B. B. Tags: Additions and Corrections Source Type: research

Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax. Additions and Corrections
This article has been retracted by the publisher. An investigation at MD Anderson determined that the image of medium control and the image of DR4+DR5 siRNA treated with TRAIL in Fig. 3B were reused.
Source: Journal of Biological Chemistry - August 4, 2016 Category: Chemistry Authors: Gupta, S. C., Reuter, S., Phromnoi, K., Park, B., Hema, P. S., Nair, M., Aggarwal, B. B. Tags: Additions and Corrections Source Type: research

TrpC5 Regulates ABCB1 Production in Colorectal Cancer Signal Transduction
5-Fluorouracil (5-Fu) is commonly used in the chemotherapy of colorectal cancer (CRC), but resistance to 5-Fu occurs in most cases, allowing cancer progression. Suppressing ABCB1 (ATP-binding cassette, subfamily B, member 1), which is a pump overproduced in cancer cells to export cytotoxic drugs, is an attractive strategy to overcome drug resistance. In the present study, transient receptor potential channel TrpC5 was found to be overproduced at the mRNA and protein levels together with ABCB1 in 5-Fu-resistant human CRC HCT-8 (HCT-8/5-Fu) and LoVo (LoVo/5-Fu) cells. More nuclear-stabilized β-catenin accumulation was found...
Source: Journal of Biological Chemistry - January 2, 2015 Category: Chemistry Authors: Wang, T., Chen, Z., Zhu, Y., Pan, Q., Liu, Y., Qi, X., Jin, L., Jin, J., Ma, X., Hua, D. Tags: Cell Biology Source Type: research