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TNFAIP2 confers cisplatin resistance in head and neck squamous cell carcinoma via KEAP1/NRF2 signaling
CONCLUSIONS: Our results reveal the antioxidant and cisplatin resistance-regulating roles of the TNFAIP2/KEAP1/NRF2/JNK axis in HNSCC, suggesting that TNFAIP2 might be a potential target in improving the cisplatin treatment effect, particularly for patients with cisplatin resistance.PMID:37525222 | PMC:PMC10391982 | DOI:10.1186/s13046-023-02775-1
Source: Cell Research - July 31, 2023 Category: Cytology Authors: Teng Xu Yuemei Yang Zhihong Chen Jinsong Wang Xiaolei Wang Yang Zheng Chao Wang Yachen Wang Zaiou Zhu Xu Ding Junbo Zhou Gang Li Hongchuang Zhang Wei Zhang Yunong Wu Xiaomeng Song Source Type: research

Promotion of ferroptosis in head and neck cancer with divalent metal transporter 1 inhibition or salinomycin
We examined the role of DMT1 inhibition or salinomycin in promoting ferroptosis by lysosomal iron targeting in HNC cells. RNA interference was performed by transfection of siRNA targeting DMT1 or scrambled control siRNA in HNC cell lines. Cell death and viability, lipid peroxidation, iron contents, and molecular expression were compared between the DMT1 silencing or salinomycin group and the control. DMT1 silencing markedly accelerated cell death induced by the ferroptosis inducers. DMT1 silencing marked increases in the labile iron pool, intracellular ferrous and total iron contents, and lipid peroxidation. DMT1 silencing...
Source: Human Cell - March 8, 2023 Category: Cytology Source Type: research

HPV-mediated regulation of SMAD4 modulates the DNA damage response in head and neck cancer
CONCLUSIONS: Our results give a clear molecular mechanism at the basis of HPV regulation of the DDR pathway. In particular, we show how HPV stabilizes SMAD4 to promote DDR protein expression, which may be used to facilitate viral replication and HNC onset. Moreover, we found that SMAD4 silencing in HPV-positive HNC cell lines increases sensitivity to cisplatin treatment, suggesting that HPV-positive HNC with low SMAD4 expression may be preferentially susceptible to similar treatments.PMID:35144669 | DOI:10.1186/s13046-022-02258-9
Source: Cell Research - February 11, 2022 Category: Cytology Authors: Simona Citro Claudia Miccolo Alessandro Medda Lavinia Ghiani Marta Tagliabue Mohssen Ansarin Susanna Chiocca Source Type: research

Upregulation of microRNA-141 contributes to suppressing epithelial-mesenchymal transition and lymph node metastasis in laryngeal cancer through HOXC6-dependent TGF- β signaling pathway.
In this study, we aim to explore the roles of microRNA-141 (miR-141), Homeobox C6 (HOXC6) and TGF-β signaling pathway in epithelial-mesenchymal transition (EMT) and lymph node metastasis in laryngeal cancer. Initially, we identified differentially expressed genes in laryngeal cancer, among which HOXC6 was identified. Then the target miRNA of HOXC6 was predicted and verified. Next, expression of miR-141, HOXC6, TGF-β1, Smad3, Vimentin and Snail in cancer tissues was detected. Then, AMC-HN-8 cells were transfected with miR-141 mimic, miR-141 inhibitor and HOXC6-siRNA to investigate specific role of miR-141, HOXC6 and TGF-�...
Source: Cellular Signalling - October 15, 2019 Category: Cytology Authors: Chen L, Sun DZ, Fu YG, Yang PZ, Lv HQ, Gao Y, Zhang XY Tags: Cell Signal Source Type: research

Hippo/Mst1 overexpression induces mitochondrial death in head and neck squamous cell carcinoma via activating β-catenin/Drp1 pathway.
Abstract Mammalian Ste20-like kinase 1 (Mst1) is associated with cell apoptosis. In the current study, we explored the regulatory effects of Mst1 on squamous cell carcinoma of the head and neck (SCCHN) in vitro. SCCHN Cal27 cells and Tu686 cells were transfected with adenovirus-loaded Mst1 to detect the role of Mst1 in cell viability. Then, siRNA against Drp1 was transfected into cells to evaluate the influence of mitochondrial fission in cancer survival. Our data illustrated that Mst1 overexpression promoted SCCHN Cal27 cell and Tu686 cell death via activating mitochondria-related apoptosis. Cells transfected wit...
Source: Cell Stress and Chaperones - May 23, 2019 Category: Cytology Authors: Ma C, Fan L, Wang J, Hao L, He J Tags: Cell Stress Chaperones Source Type: research

Upregulated MicroRNA-141 Suppresses Epithelial-Mesenchymal Transition and Lymph Node Metastasis via HOXC6-Dependent TGF- β Signaling Pathway in Laryngeal Cancer.
This study investigated the roles of microRNA-141 (miR-141), Homeobox C6 (HOXC6), and the transforming growth factor-β (TGF-β) signaling pathway in epithelial-mesenchymal transition (EMT) and lymph node metastasis in laryngeal cancer. Initially, differentially expressed genes related to laryngeal cancer were retrieved, from which HOXC6 was identified. Next, HOXC6 was determined to be a target gene of miR-141. The regulatory relationship of miR-141, HOXC6 and the TGF-β signaling pathway were then explored accordingly. To further investigate the associated underlying mechanism, Hep-2 cells were transfected with miR-141 mi...
Source: Am J Physiol Cell Ph... - April 23, 2019 Category: Cytology Authors: Sun DZ, Wang XH, Fu YG, Yang PZ, Lv HQ, Yin YW, Zhang XY Tags: Am J Physiol Cell Physiol Source Type: research

The Nedd8 ‐activating enzyme inhibitor MLN4924 (TAK‐924/Pevonedistat) induces apoptosis via c‐Myc‐Noxa axis in head and neck squamous cell carcinoma
ConclusionsThese findings determined the over ‐expression levels of neddylation enzymes in HNSCC and revealed novel mechanisms underlying neddylation inhibition induced growth suppression in HNSCC cells, which provided preclinical evidence for further clinical evaluation of neddylation inhibitors (eg, MLN4924) for the treatment of HNSCC.
Source: Cell Proliferation - October 19, 2018 Category: Cytology Authors: Wenjuan Zhang, Yupei Liang, Lihui Li, Xiaofang Wang, Zi Yan, Changsheng Dong, Mu ‐Sheng Zeng, Qian Zhong, Xue‐Kui Liu, Jinha Yu, Shuyang Sun, Xiaojun Liu, Jihui Kang, Hu Zhao, Lak Shin Jeong, Yanmei Zhang, Lijun Jia Tags: ORIGINAL ARTICLE Source Type: research

MCP1-Induced Epithelial-Mesenchymal Transition in Head and Neck Cancer by AKT Activation.
CONCLUSION: The overexpression of MCP1 in HNC cells may partially induce EMT through the AKT pathway. A high cellular expression of MCP1 was associated with pathological neck metastases. PMID: 26026089 [PubMed - in process]
Source: Cell Research - June 1, 2015 Category: Cytology Authors: Lee CC, Ho HC, Su YC, Lee MS, Hung SK, Lin CH Tags: Anticancer Res Source Type: research