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Attenuation of cancer proliferation by suppression of glypican-1 and its pleiotropic effects in neoplastic behavior
Oncotarget. 2023 Mar 21;14:219-235. doi: 10.18632/oncotarget.28388.ABSTRACTGlypicans (GPC1-6) are associated with tumorigenic processes and their involvement in neoplastic behavior has been discussed in different cancer types. Here, a cancer-wide GPC expression study, using clinical cancer patient data in The Cancer Genome Atlas, reveals net upregulation of GPC1 and GPC2 in primary solid tumors, whereas GPC3, GPC5 and GPC6 display lowered expression pattern compared to normal tissues. Focusing on GPC1, survival analyses of the clinical cancer patient data reveal statistically significant correlation between high expression...
Source: Oncotarget - March 21, 2023 Category: Cancer & Oncology Authors: Fang Cheng Victor Ch érouvrier Hansson Grigorios Georgolopoulos Katrin Mani Source Type: research

Cancers, Vol. 14, Pages 3122: Cordycepin (3 & prime;-Deoxyadenosine) Suppresses Heat Shock Protein 90 Function and Targets Tumor Growth in an Adenosine Deaminase-Dependent Manner
Cancers, Vol. 14, Pages 3122: Cordycepin (3′-Deoxyadenosine) Suppresses Heat Shock Protein 90 Function and Targets Tumor Growth in an Adenosine Deaminase-Dependent Manner Cancers doi: 10.3390/cancers14133122 Authors: Su-Chan Lee Lujain Alaali HyukJean Kwon Mohammed Rigi Charles G. Eberhart Alterations in metabolism and energy production are increasingly being recognized as important drivers of neoplasia, raising the possibility that metabolic analogs could disrupt oncogenic pathways. 3′-deoxyadenosine, also known as cordycepin, is an adenosine analog that inhibits the growth of sever...
Source: Cancers - June 25, 2022 Category: Cancer & Oncology Authors: Su-Chan Lee Lujain Alaali HyukJean Kwon Mohammed Rigi Charles G. Eberhart Tags: Article Source Type: research

Sclerostin Suppression Facilitates Uveal Melanoma Progression Through Activating Wnt/ β-Catenin Signaling Via Binding to Membrane Receptors LRP5/LRP6
ConclusionSOST silencing may facilitate the malignant progression of UM cells through activating Wnt/β-catenin signaling. Mechanistically, SOST may exert this function by interacting with LRP5/LRP6 membrane receptors.
Source: Frontiers in Oncology - June 17, 2022 Category: Cancer & Oncology Source Type: research

MiR-26a inhibits proliferation and apoptosis of uveal melanoma cells via regulating p53/MDM2 pathway.
CONCLUSIONS: Highly expressed miR-26a can inhibit the proliferation and promote apoptosis of SP6.5 cells, whose potential mechanism may be related to the regulation on the p53/MDM2 pathway. PMID: 33277871 [PubMed - as supplied by publisher]
Source: Journal of B.U.ON. - December 7, 2020 Category: Cancer & Oncology Tags: J BUON Source Type: research

Pristimerin-induced uveal melanoma cell death via inhibiting PI3K/Akt/FoxO3a signalling pathway.
Abstract Uveal melanoma (UM) is a highly invasive intraocular malignancy with high mortality. Presently, there is no FDA-approved standard for the treatment of metastatic UM. Pristimerin is a natural quinine methide triterpenoid compound with anti-angiogenic, anti-cancer and anti-inflammatory activities. However, Pristimerin potential cytotoxic effect on UM was poorly investigated. In the present study, we found the migration and invasion of UM-1 cells were inhibited by Pristimerin which also caused a rapid increase of ROS, decreased mitochondrial membrane potential, induced the accumulation of cells in G0/G1 phas...
Source: J Cell Mol Med - April 28, 2020 Category: Molecular Biology Authors: Yan F, Liao R, Silva M, Li S, Jiang Y, Peng T, Lazarovici P, Zheng W Tags: J Cell Mol Med Source Type: research

Efficient Inhibition of Uveal Melanoma via Ternary siRNA Complexes
Publication date: Available online 23 November 2019Source: International Journal of PharmaceuticsAuthor(s): Lingxiao Xie, Yan Yang, Jie ShenAbstractUveal melanoma (UM) is rare yet the most common and malignant primary intraocular tumor in adults. Due to the lack of effective treatment, the mortality rate of UM has remained high over the past few decades. In the present study, hyaluronic acid (HA) coated chitosan (Chi)/siRNA ternary complexes have been developed and characterized as a novel therapeutic strategy molecularly targeting hypoxia-inducible factor 1α (HIF-1α) pathway for the treatment of UM. The cytotoxicity, ce...
Source: International Journal of Pharmaceutics - November 23, 2019 Category: Drugs & Pharmacology Source Type: research

Cancers, Vol. 11, Pages 1278: Increased Non-Homologous End Joining Makes DNA-PK a Promising Target for Therapeutic Intervention in Uveal Melanoma
This study has shown that sister chromatid exchange (SCE) is low in UM which is likely due to a reduced expression of FANCD2. As FANCD2 can function to suppress non-homologous end joining (NHEJ), this study therefore investigated NHEJ in UM. The activation of the catalytic subunit of the NHEJ pathway protein DNA-dependent protein kinase (DNA-PK) was measured by analysing the foci formation and the ligation efficiency by NHEJ determined using a plasmid-based end-joining assay. Using small-interfering RNA (siRNA) knock-down, and chemical inhibitors of DNA-PK, the survival of primary UM cultures and two cell lines were determ...
Source: Cancers - August 29, 2019 Category: Cancer & Oncology Authors: Doherty Bryant Valluru Rennie Sisley Tags: Article Source Type: research

Complement C5b-9 and Cancer: Mechanisms of Cell Damage, Cancer Counteractions, and Approaches for Intervention
In conclusion, osmotic burst of inflated complement-damaged cells may occur, but these bursts are most likely a consequence of metabolic collapse of the cell rather than the cause of cell death. The Complement Cell Death Mediator: A Concerted Action of Toxic Moieties Membrane pores caused by complement were first visualized by electron microscopy on red blood cell membranes as large ring structures (22). Similar lesions were viewed on E. coli cell walls (23). Over the years, ample information on the fine ultrastructure of the MAC that can activate cell death has been gathered (24) and has been recently further examined (...
Source: Frontiers in Immunology - April 9, 2019 Category: Allergy & Immunology Source Type: research

Elucidating the role of the FoxO3a transcription factor in the IGF-1-induced migration and invasion of uveal melanoma cancer cells.
Abstract Uveal melanoma (UM) is the most common primary intraocular malignant tumor of adults. It has high mortality rate due to liver metastasis. However, the epidemiology and pathogenesis of liver metastasis in UM are not elucidated and there is no effective therapy available for preventing the development of this disease. IGF-1 is a growth factor involved in cell proliferation, malignant transformation and inhibition of apoptosis. In previous report, IGF-1 receptor was found to be highly expressed in UM and this was related to tumor prognosis. FoxO3a is a Forkhead box O (FOXO) transcription factor and a downstr...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - November 19, 2016 Category: Drugs & Pharmacology Authors: Yan F, Liao R, Farhan M, Wang T, Chen J, Wang Z, Little PJ, Zheng W Tags: Biomed Pharmacother Source Type: research

Abstract 3334: The role of nuclear HER3 in breast cancer resistance
HER3 is reported to be overexpressed in 18-29% of human breast cancers and suggested to be a marker of reduced disease-specific survival in 4,406 patients with invasive breast carcinoma. Overexpression and subcellular localization of HER3 may be a negative predictive marker for targeted therapies, and HER3 status may play a role in the development of drug resistance and metastasis. Translocation of ERBB family members EGFR, HER2 and HER4 into nucleus for regulating gene transcription have been reported, but only a few studies about nuclear HER3 have been reported and the biological role of nuclear HER3 is still unknown. HE...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Tang, P. M. K., Khoo, U. S., Harris, A. L., Kong, A. Tags: Molecular and Cellular Biology Source Type: research