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Therapy: Statin Therapy
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Total 12097 results found since Jan 2013.
Concomitant Coronary Atheroma Regression and Stabilization in Response to Lipid-Lowering Therapy
CONCLUSIONS: Triple regression occurred in one third of AMI patients receiving high-intensity lipid-lowering therapy and was associated with alirocumab treatment, higher baseline lipid content and reduced cardiovascular events.PMID:37640248 | DOI:10.1016/j.jacc.2023.08.019
Source: Atherosclerosis - August 28, 2023 Category: Cardiology Authors: Flavio G Biccir è Jonas H äner Sylvain Losdat Yasushi Ueki Hiroki Shibutani Tatsuhiko Otsuka Ryota Kakizaki Thomas M Hofbauer Robert-Jan van Geuns Stefan Stortecky Georgios Cm Siontis Sarah B är Jacob L ønborg Dik Heg Christoph Kaiser David Spirk Joos Source Type: research
Recommendations for statin management in primary prevention: disparities among international risk scores
CONCLUSION: Risk algorithms differ substantially in their estimation of risk, recommendations for statin treatment, and use of ancillary testing, even in identical patients. These results highlight the limitations of currently used risk-based approaches for addressing lipid-specific risk in primary prevention.PMID:37638490 | DOI:10.1093/eurheartj/ehad539
Source: Atherosclerosis - August 28, 2023 Category: Cardiology Authors: G B John Mancini Arnold Ryomoto Eunice Yeoh Liam R Brunham Robert A Hegele Source Type: research
Silent Myocardial Infarction: A Case Report
We present a case of a 59-year-old overweight woman with prediabetes, primary hypertension, and hypercholesterolemia who presented for herpes zoster (HZ) follow-up; she reported having skipped heartbeats and heart rate fluctuations during the review of systems. On further workup, ECG revealed low voltage QRS complexes, flat QRS complexes, flat T waves, and pathological Q waves, suggesting the diagnosis of SMI. Based on the identified risk factors, including high BMI, prediabetes, primary hypertension, hypercholesterolemia, HZ, and newly diagnosed SMI, the patient was advised to continue with lisinopril 20 mg daily, prescri...
Source: Herpes - August 28, 2023 Category: Infectious Diseases Authors: Maria V Kolesova Suzanne Minor Source Type: research
Coronary Artery Calcium Scoring for Cardiovascular Risk Assessment in Patients with Inflammatory Bowel Disease
CONCLUSION: Subclinical atherosclerosis, as evaluated by CAC scoring, is prevalent in patients with IBD, and is associated with cardiovascular events. Further studies are needed to understand underlying biological processes of increased atherosclerotic disease risk among adults with IBD.PMID:37634654 | DOI:10.1016/j.ahj.2023.08.011
Source: Atherosclerosis - August 27, 2023 Category: Cardiology Authors: Robert Naami Nour Tashtish Ian J Neeland Jeffry Katz Preetika Sinh Khurram Nasir Vibhu Chittajallu Emad Mansoor Sanjay Rajagopalan Sadeer Al-Kindi Source Type: research
Atorvastatin reduces renal interstitial fibrosis caused by unilateral ureteral obstruction through inhibiting the transcriptional activity of YAP
In this study, we established a mouse model of obstructive kidney disease induced by unilateral ureteral obstruction (UUO). The UUO procedure significantly upregulated YAP and fibrosis-related gene expression in a time-dependent manner. Morphologically, the renal fibrotic lesions associated with hydronephrosis progressively worsened over time in the UUO group. Atorvastatin, which is widely used to lower blood cholesterol levels, has recently been shown to inhibit Yes1 associated protein (YAP). We treated UUO mice with atorvastatin for 3 and 10 days and observed a decrease in the expression of YAP and fibrosis-related genes...
Source: Biochemical and Biophysical Research communications - August 26, 2023 Category: Biochemistry Authors: Jun Wang Zhichao Wang Fan Xia Qiong Duan Xiaoping Peng Source Type: research
Novel Anti-Inflammatory Therapies in Coronary Artery Disease and Acute Coronary Syndromes
Life (Basel). 2023 Jul 31;13(8):1669. doi: 10.3390/life13081669.ABSTRACTEvidence suggests that inflammation plays an important role in atherosclerosis and the consequent clinical presentation, including stable coronary artery disease (CAD) and acute coronary syndromes (ACS). The most essential elements are cytokines, proteins with hormone-like properties that are produced by the immune cells, endothelial cells, platelets, fibroblasts, and some stromal cells. Interleukins (IL-1β and IL-6), chemokines, interferon-γ (IFN-γ), and tumor necrosis factor-alpha (TNF-α) are the cytokines commonly associated with endothelial dys...
Source: Atherosclerosis - August 26, 2023 Category: Cardiology Authors: Yannis Dimitroglou Constantina Aggeli Panagiotis Theofilis Panagiotis Tsioufis Evangelos Oikonomou Christos Chasikidis Konstantinos Tsioufis Dimitris Tousoulis Source Type: research
Application of Atorvastatin Combined with Ezetimibe in Elderly Patients with Hypertension Combined with T2DM and Analysis of Significance of Changes in Serum Bilirubin Levels During Treatment
CONCLUSION: AT combined with EZ can effectively improve glucose, lipids, inflammation and upregulate serum bilirubin in patients with HY combined with T2DM.PMID:37632947
Source: Alternative Therapies in Health and Medicine - August 26, 2023 Category: Complementary Medicine Authors: Siyu Zhu Tehasi Wang Qingyi Wang Mengyu Du Source Type: research
Novel Anti-Inflammatory Therapies in Coronary Artery Disease and Acute Coronary Syndromes
Life (Basel). 2023 Jul 31;13(8):1669. doi: 10.3390/life13081669.ABSTRACTEvidence suggests that inflammation plays an important role in atherosclerosis and the consequent clinical presentation, including stable coronary artery disease (CAD) and acute coronary syndromes (ACS). The most essential elements are cytokines, proteins with hormone-like properties that are produced by the immune cells, endothelial cells, platelets, fibroblasts, and some stromal cells. Interleukins (IL-1β and IL-6), chemokines, interferon-γ (IFN-γ), and tumor necrosis factor-alpha (TNF-α) are the cytokines commonly associated with endothelial dys...
Source: Atherosclerosis - August 26, 2023 Category: Cardiology Authors: Yannis Dimitroglou Constantina Aggeli Panagiotis Theofilis Panagiotis Tsioufis Evangelos Oikonomou Christos Chasikidis Konstantinos Tsioufis Dimitris Tousoulis Source Type: research
Acute Myocardial Infarction and Risk of Cognitive Impairment and Dementia: A Review
Biology (Basel). 2023 Aug 21;12(8):1154. doi: 10.3390/biology12081154.ABSTRACTCognitive impairment (CI) shares common cardiovascular risk factors with acute myocardial infarction (AMI), and is increasingly prevalent in our ageing population. Whilst AMI is associated with increased rates of CI, CI remains underreported and infrequently identified in patients with AMI. In this review, we discuss the evidence surrounding AMI and its links to dementia and CI, including pathophysiology, risk factors, management and interventions. Vascular dysregulation plays a major role in CI, with atherosclerosis, platelet activation, microin...
Source: Atherosclerosis - August 26, 2023 Category: Cardiology Authors: Elizabeth Hui En Thong Ethan J W Quek Jing Hong Loo Choi-Ying Yun Yao Neng Teo Yao Hao Teo Aloysius S T Leow Tony Y W Li Vijay K Sharma Benjamin Y Q Tan Leonard L L Yeo Yao Feng Chong Mark Y Chan Ching-Hui Sia Source Type: research
Application of Atorvastatin Combined with Ezetimibe in Elderly Patients with Hypertension Combined with T2DM and Analysis of Significance of Changes in Serum Bilirubin Levels During Treatment
CONCLUSION: AT combined with EZ can effectively improve glucose, lipids, inflammation and upregulate serum bilirubin in patients with HY combined with T2DM.PMID:37632947
Source: Alternative Therapies in Health and Medicine - August 26, 2023 Category: Complementary Medicine Authors: Siyu Zhu Tehasi Wang Qingyi Wang Mengyu Du Source Type: research
A Systematic Review and Meta-analysis on the Role of Statins in the Prevention of Mortality Following Pancreatic Cancer
CONCLUSION: Statins reduce the risk of mortality in patients with PC. However, no significant relation has been observed in RCTs. Therefore, it is necessary to be cautious in interpreting the results.PMID:37622694 | DOI:10.2174/1871520623666230824095226
Source: Cancer Control - August 25, 2023 Category: Cancer & Oncology Authors: Khatereh Anbari Mehdi Mohammadian Amiri Saeid Heidari-Soureshjani Catherine Mt Sherwin Karamali Kasiri Source Type: research
Coronary CT angiography and coronary atherosclerosis : Where do we stand today?
Herz. 2023 Aug 25. doi: 10.1007/s00059-023-05207-0. Online ahead of print.ABSTRACTCardiac computed tomography (CT) has made substantial progress in recent years. The main field of application is CT coronary angiography for visualization of the coronary arteries and for the detection and exclusion of coronary artery stenosis. This has been included in international guidelines for the management of stable coronary artery disease or chronic coronary syndrome as well as for the diagnostic work-up of patients with acute chest pain; however, it must be taken into account that the diagnostic validity is only sufficiently high whe...
Source: Atherosclerosis - August 25, 2023 Category: Cardiology Authors: Stephan Achenbach Source Type: research
Acute hepatitis of unknown etiology in an adult female: A case report
CONCLUSION: Idiopathic hepatitis makes treatment challenging. It can leave patients feeling confused and unfulfilled. Thus, educating the patient thoroughly for shared decision-making and management becomes essential.PMID:37621598 | PMC:PMC10445075 | DOI:10.12998/wjcc.v11.i22.5288
Source: Herpes - August 25, 2023 Category: Infectious Diseases Authors: Lucinda Dass Alexandra Marie Malabanan Pacia Mahgol Hamidi Source Type: research
