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Total 39135 results found since Jan 2013.
Confounding Effects of Tamoxifen: Cautionary and Practical Considerations for the Use of Tamoxifen-Inducible Mouse Models in Atherosclerosis Research
CONCLUSIONS: In this study, we establish that tamoxifen administration results in decreased serum cholesterol, decreased plaque formation, and increased hepatic lipid accumulation. These alterations represent significant confounding variables in atherosclerosis research, and we urge future investigators to take these findings into consideration when planning and executing their own atherosclerosis experiments.PMID:37706321 | DOI:10.1161/ATVBAHA.123.319922
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 14, 2023 Category: Cardiology Authors: Allison M Dubner Sizhao Lu Austin J Jolly Tysen Noble Tyler Hinthorn Raphael A Nemenoff Karen S Moulton Mark W Majesky Mary C M Weiser-Evans Source Type: research
Single-Cell RNA Sequencing of Coronary Perivascular Adipose Tissue From End-Stage Heart Failure Patients Identifies < em > SPP1 < /em > < sup > + < /sup > Macrophage Subpopulation as a Target for Alleviating Fibrosis
CONCLUSIONS: SPP1+ macrophages accumulated in the PVAT surrounding atherosclerotic coronary arteries, and they promoted the migration and proliferation of fibroadipogenic progenitor cells via OPN-CD44/integrin interaction and thus aggravated the fibrosis of coronary PVAT, which was positively correlated to the coronary stenosis burden. Therefore, SPP1+ macrophages in coronary PVAT may participate in the progression of coronary atherosclerosis.PMID:37706320 | DOI:10.1161/ATVBAHA.123.319828
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 14, 2023 Category: Cardiology Authors: Mengxia Fu Songren Shu Zhiming Peng Xiaorui Liu Xiao Chen Zhiwei Zeng Yicheng Yang Hao Cui Ruojin Zhao Xiaohu Wang Leilei Du Min Wu Wei Feng Jiangping Song Source Type: research
Confounding Effects of Tamoxifen: Cautionary and Practical Considerations for the Use of Tamoxifen-Inducible Mouse Models in Atherosclerosis Research
CONCLUSIONS: In this study, we establish that tamoxifen administration results in decreased serum cholesterol, decreased plaque formation, and increased hepatic lipid accumulation. These alterations represent significant confounding variables in atherosclerosis research, and we urge future investigators to take these findings into consideration when planning and executing their own atherosclerosis experiments.PMID:37706321 | DOI:10.1161/ATVBAHA.123.319922
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 14, 2023 Category: Cardiology Authors: Allison M Dubner Sizhao Lu Austin J Jolly Tysen Noble Tyler Hinthorn Raphael A Nemenoff Karen S Moulton Mark W Majesky Mary C M Weiser-Evans Source Type: research
Sex and Racial Disparities in Peripheral Artery Disease
Arterioscler Thromb Vasc Biol. 2023 Sep 14. doi: 10.1161/ATVBAHA.123.319399. Online ahead of print.ABSTRACTSeveral studies have shown that women and racial and ethnic minority patients are at increased risk of developing lower extremity peripheral artery disease and suffering adverse outcomes from it, but a knowledge gap remains regarding the underlying causes of these increased risks. Both groups are more likely to be underdiagnosed, have poorly managed contributory comorbidities, and incur disparities in treatment and management postdiagnosis. Opportunities for improvement in the care of women and racial and ethnic minor...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 14, 2023 Category: Cardiology Authors: Sanjay Divakaran Anna K Krawisz Eric A Secemsky Shashi Kant Source Type: research
Single-Cell RNA Sequencing of Coronary Perivascular Adipose Tissue From End-Stage Heart Failure Patients Identifies < em > SPP1 < /em > < sup > + < /sup > Macrophage Subpopulation as a Target for Alleviating Fibrosis
CONCLUSIONS: SPP1+ macrophages accumulated in the PVAT surrounding atherosclerotic coronary arteries, and they promoted the migration and proliferation of fibroadipogenic progenitor cells via OPN-CD44/integrin interaction and thus aggravated the fibrosis of coronary PVAT, which was positively correlated to the coronary stenosis burden. Therefore, SPP1+ macrophages in coronary PVAT may participate in the progression of coronary atherosclerosis.PMID:37706320 | DOI:10.1161/ATVBAHA.123.319828
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 14, 2023 Category: Cardiology Authors: Mengxia Fu Songren Shu Zhiming Peng Xiaorui Liu Xiao Chen Zhiwei Zeng Yicheng Yang Hao Cui Ruojin Zhao Xiaohu Wang Leilei Du Min Wu Wei Feng Jiangping Song Source Type: research
Aggressive LDL-C Lowering and the Brain: Impact on Risk for Dementia and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association
The objective of this scientific statement is to evaluate contemporary evidence that either supports or refutes the conclusion that aggressive low-density lipoprotein cholesterol lowering or lipid lowering exerts toxic effects on the brain, leading to cognitive impairment or dementia or hemorrhagic stroke. The writing group used literature reviews, references to published clinical and epidemiology studies, clinical and public health guidelines, authoritative statements, and expert opinion to summarize existing evidence and to identify gaps in current knowledge. Although some retrospective, case control, and prospective lon...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 14, 2023 Category: Cardiology Authors: Larry B Goldstein Peter P Toth Jennifer L Dearborn-Tomazos Robert P Giugliano Benjamin J Hirsh Jessica M Pe ña Magdy H Selim Daniel Woo American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular and Source Type: research
Sex and Racial Disparities in Peripheral Artery Disease
Arterioscler Thromb Vasc Biol. 2023 Sep 14. doi: 10.1161/ATVBAHA.123.319399. Online ahead of print.ABSTRACTSeveral studies have shown that women and racial and ethnic minority patients are at increased risk of developing lower extremity peripheral artery disease and suffering adverse outcomes from it, but a knowledge gap remains regarding the underlying causes of these increased risks. Both groups are more likely to be underdiagnosed, have poorly managed contributory comorbidities, and incur disparities in treatment and management postdiagnosis. Opportunities for improvement in the care of women and racial and ethnic minor...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 14, 2023 Category: Cardiology Authors: Sanjay Divakaran Anna K Krawisz Eric A Secemsky Shashi Kant Source Type: research
Aggressive LDL-C Lowering and the Brain: Impact on Risk for Dementia and Hemorrhagic Stroke: A Scientific Statement From the American Heart Association
The objective of this scientific statement is to evaluate contemporary evidence that either supports or refutes the conclusion that aggressive low-density lipoprotein cholesterol lowering or lipid lowering exerts toxic effects on the brain, leading to cognitive impairment or dementia or hemorrhagic stroke. The writing group used literature reviews, references to published clinical and epidemiology studies, clinical and public health guidelines, authoritative statements, and expert opinion to summarize existing evidence and to identify gaps in current knowledge. Although some retrospective, case control, and prospective lon...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 14, 2023 Category: Cardiology Authors: Larry B Goldstein Peter P Toth Jennifer L Dearborn-Tomazos Robert P Giugliano Benjamin J Hirsh Jessica M Pe ña Magdy H Selim Daniel Woo American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular and Source Type: research
Biomechanical characterization of tissue types in murine dissecting aneurysms based on histology and 4D ultrasound-derived strain
Biomech Model Mechanobiol. 2023 Sep 14. doi: 10.1007/s10237-023-01759-6. Online ahead of print.ABSTRACTAbdominal aortic aneurysm disease is the local enlargement of the aorta, typically in the infrarenal section, causing up to 200,000 deaths/year. In vivo information to characterize the individual elastic properties of the aneurysm wall in terms of rupture risk is lacking. We used a method that combines 4D ultrasound and direct deformation estimation to compute in vivo 3D Green-Lagrange strain in murine angiotensin II-induced dissecting aortic aneurysms, a commonly used mouse model. After euthanasia, histological staining ...
Source: Biomechanics and Modeling in Mechanobiology - September 14, 2023 Category: Biomedical Science Authors: Achim Hegner Hannah L Cebull Antonio J G ámez Christopher Blase Craig J Goergen Andreas Wittek Source Type: research
The impact of frailty evaluation on the risk of venous thromboembolism in patients with hip fracture following surgery: a meta-analysis
CONCLUSION: Frailty is associated with a higher incidence of postoperative VTE in patients with hip fracture.PMID:37707745 | DOI:10.1007/s40520-023-02529-1
Source: Aging Clinical and Experimental Research - September 14, 2023 Category: Geriatrics Authors: Haixia Zhang Fang Wu Jianbin Sun Yongchao Liu Zifu Zhou Xuejun Wu Bin Liang Source Type: research
Biomechanical characterization of tissue types in murine dissecting aneurysms based on histology and 4D ultrasound-derived strain
Biomech Model Mechanobiol. 2023 Sep 14. doi: 10.1007/s10237-023-01759-6. Online ahead of print.ABSTRACTAbdominal aortic aneurysm disease is the local enlargement of the aorta, typically in the infrarenal section, causing up to 200,000 deaths/year. In vivo information to characterize the individual elastic properties of the aneurysm wall in terms of rupture risk is lacking. We used a method that combines 4D ultrasound and direct deformation estimation to compute in vivo 3D Green-Lagrange strain in murine angiotensin II-induced dissecting aortic aneurysms, a commonly used mouse model. After euthanasia, histological staining ...
Source: Biomechanics and Modeling in Mechanobiology - September 14, 2023 Category: Biomedical Science Authors: Achim Hegner Hannah L Cebull Antonio J G ámez Christopher Blase Craig J Goergen Andreas Wittek Source Type: research
Role of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as potential biomarkers in Beh çet's disease: a meta-analysis
CONCLUSION: NLR and PLR can be regarded as general markers of inflammation according to the results of this meta-analysis.PMID:37707568 | DOI:10.1007/s00393-023-01412-8
Source: Zeitschrift fur Rheumatologie - September 14, 2023 Category: Rheumatology Authors: Young Ho Lee Gwan Gyu Song Source Type: research
Biomechanical characterization of tissue types in murine dissecting aneurysms based on histology and 4D ultrasound-derived strain
Biomech Model Mechanobiol. 2023 Oct;22(5):1773-1788. doi: 10.1007/s10237-023-01759-6. Epub 2023 Sep 14.ABSTRACTAbdominal aortic aneurysm disease is the local enlargement of the aorta, typically in the infrarenal section, causing up to 200,000 deaths/year. In vivo information to characterize the individual elastic properties of the aneurysm wall in terms of rupture risk is lacking. We used a method that combines 4D ultrasound and direct deformation estimation to compute in vivo 3D Green-Lagrange strain in murine angiotensin II-induced dissecting aortic aneurysms, a commonly used mouse model. After euthanasia, histological s...
Source: Biomechanics and Modeling in Mechanobiology - September 14, 2023 Category: Biomedical Science Authors: Achim Hegner Hannah L Cebull Antonio J G ámez Christopher Blase Craig J Goergen Andreas Wittek Source Type: research
Safety and effectiveness of stent-assisted coiling with adjunctive techniques in ruptured acute aneurysms: a propensity score-matched cohort study
CONCLUSIONS: Although stent treatment for RIA results in some incidents of complications, it is safe and effective. Besides, the SAC group showed better vascular imaging results compared with the CA group.PMID:37708395 | DOI:10.3171/2023.7.JNS231133
Source: Journal of Neurosurgery - September 14, 2023 Category: Neurosurgery Authors: Ziwei Chen Yanhong Xin Liang Zou Ji Ma Chengbao Yang Source Type: research
The impact of frailty evaluation on the risk of venous thromboembolism in patients with hip fracture following surgery: a meta-analysis
CONCLUSION: Frailty is associated with a higher incidence of postoperative VTE in patients with hip fracture.PMID:37707745 | DOI:10.1007/s40520-023-02529-1
Source: Aging Clinical and Experimental Research - September 14, 2023 Category: Geriatrics Authors: Haixia Zhang Fang Wu Jianbin Sun Yongchao Liu Zifu Zhou Xuejun Wu Bin Liang Source Type: research
