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Nutrition: Vitamin D

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Total 30 results found since Jan 2013.

A Novel De Novo Frameshift Pathogenic Variant in the FAM111B Resulting in Progressive Osseous Heteroplasia Phenotype
ConclusionThis is the first case of POH phenotype associated with a novel de novo pathogenic frameshift variant inFAM111B. Whether the frameshift change inFAM111B predicts POH remains unclear. Further evaluations are necessary to fully elucidate this finding and the potential role and mechanism by which theFAM111B variants contributes to POH phenotype.
Source: Calcified Tissue International - December 27, 2022 Category: Orthopaedics Source Type: research

Crohn & #39;s Disease Presenting as Metabolic Myopathy: A Case Report
We report a 20-yearr-old lady who presented with a painful proximal myopathy. On examination, she was malnourished with pallor, angular cheilitis, Bitots spots, and bilateral pitting pedal edema. Laboratory evaluation showed iron deficiency anemia, hypoalbuminemia, and very low vitamin D levels with elevated creatine phosphokinase levels. A possibility of osteomalacic metabolic myopathy due to vitamin D deficiency was considered. The malabsorption workup was negative. A colonoscopic biopsy showed noncaseating granulomatous inflammation suggestive of Crohn's disease. With supplementary therapy and specific treatm...
Source: Neurology India - July 1, 2022 Category: Neurology Authors: Sabu Kunnathuparambil George Neena Baby Prasanth Varghese Thalakottur Kuriakose Joseph Source Type: research

Epidemiological and genetic features of anti-3 ‑hydroxy-3-methylglutaryl-CoA reductase necrotizing myopathy: Single-center experience and literature review
CONCLUSION: In northern Spain, anti-HMGCR IMNM preferentially affects people over 50 years of age who are carriers of the HLA-DRB1*11 allele and take statins. Both low vitamin D levels and hypothyroidism may play a potential predisposing role in the development of this disease.PMID:35487805 | DOI:10.1016/j.ejim.2022.04.017
Source: European Journal of Internal Medicine - April 29, 2022 Category: Internal Medicine Authors: Diana Prieto-Pe ña Javier G Ocejo-Vinyals Joel Mazariegos-Cano Ana L Pelayo-Negro Sara Remuzgo-Mart ínez Fernanda Genre Alicia Garc ía-Dorta M ónica Renuncio-García V íctor M Martínez-Taboada Carmen Garc ía-Ibarbia Julio S ánchez-Martín Marcos L Source Type: research

Osteomalacic Myopathy in Children and Adolescents with Vitamin-D Deficiency
Conclusions: Vitamin-D deficiency should be considered in the differential diagnosis of proximal myopathy in children and adolescents.
Source: Neurology India - December 23, 2021 Category: Neurology Authors: Suhalika S Sahni Shruti Kakkar Ruchika Kumar Jatinder S Goraya Source Type: research

Association Between Vitamin D and Statin-Related Myopathy: A Meta-analysis
ConclusionsThe present meta-analysis provides evidence that low 25OHD level is associated with statin-related myopathy and that exogenous vitamin D supplementation can improve statin-related muscular intolerance associated with low 25OHD level in most cases. Our findings may provide useful insight for the prevention and treatment of statin-related myopathy.
Source: American Journal of Cardiovascular Drugs - July 23, 2021 Category: Cardiology Source Type: research

Vitamin D supplementation rescues simvastatin induced myopathy in mice via improving mitochondrial cristae shape.
In conclusion, these findings suggested that moderate vitamin D supplementation rescued simvastatin induced myopathy via improving the mitochondrial cristae shape and function. PMID: 32479918 [PubMed - as supplied by publisher]
Source: Toxicology and Applied Pharmacology - May 28, 2020 Category: Toxicology Authors: Ren L, Xuan L, Han F, Zhang J, Gong L, Lv Y, Zhang W, Yang S, Xu B, Yan Y, Guo L, Liu H, Wan Z, Liu L Tags: Toxicol Appl Pharmacol Source Type: research

Effect of Vitamin D Analogue on Rosuvastatin-Induced Myopathy in Wistar Rats.
Conclusion: The present study shows that the vitamin D analogue alfacalcidol prevents statin-induced myopathy. The serum CK levels are comparable to the control group on day 15 of vitamin D administration. PMID: 32292293 [PubMed - in process]
Source: The Scientific World Journal - April 16, 2020 Category: Science Tags: ScientificWorldJournal Source Type: research

Phosphate Metabolism in Health and Disease
AbstractPhosphorus, a 5A element with atomic weight of 31, comprises just over 0.6% of the composition by weight of plants and animals. Three isotopes are available for studying phosphorus metabolism and kinetics.31P is stable, whereas the radioactive isotope33P has a half-life of 25  days and32P has a half-life of 14  days. Phosphate ester and phosphoanhydride are common chemical linkages and phosphorus is a key element in organic molecules involved in a wide variety of essential cellular functions. These include biochemical energy transfer via adenosine triphosphate (ATP), maintenance of genetic information wi th nucle...
Source: Calcified Tissue International - April 6, 2020 Category: Orthopaedics Source Type: research

An overview of statin-induced myopathy and perspectives for the future.
Authors: Nikolic D, Banach M, Chianetta R, Luzzu LM, Pantea Stoian A, Diaconu CC, Citarrella R, Montalto G, Rizzo M Abstract Introduction: Statins remain the most commonly prescribed lipid-lowering drug class for the treatment of atherosclerotic cardiovascular disease. Their well-recognized side effects are known as statin-associated muscle symptom (SAMS). Some advances in this field have been made in recent years, but the understanding of the mechanisms has lagged. Investigating the specific role of the anti-HMGCR autoantibody, pharmacokinetic genetic variants, characterization of the known phenotypes of statin to...
Source: Expert Opinion on Drug Safety - April 3, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research

Vitamin D serum level in subjects with critical illness polyneuropathy and myopathy.
CONCLUSION: Almost all subjects showed Vitamin D deficiency. No difference was detected between those with and without CIPNM. The condition might represent a secondary phenomenon resulting from the inflammatory process as well as from conditions that could interfere with vitamin D metabolism. PMID: 32131367 [PubMed - in process]
Source: Journal of Musculoskeletal Neuronal Interactions - March 6, 2020 Category: Neurology Tags: J Musculoskelet Neuronal Interact Source Type: research

Worsening of unrecognized tumor-induced osteomalacia with inadvertent use of recombinant human parathyroid hormone.
Conclusion Hypophosphatemia with teriparatide use is an oddity. Unexplained hypophosphatemia in a patient on teriparatide should make the physician think of hypophosphatemic osteomalacia. Serum phosphate levels should be estimated prior to teriparatide use and its use refrained in patients with unexplained hypophosphatemia. PMID: 31566250 [PubMed - as supplied by publisher]
Source: Endokrynologia Polska - September 29, 2019 Category: Endocrinology Authors: Pal R, Agrawal K, Gupta S, Bhansali A, Behera A, Bhadada SK Tags: Endokrynol Pol Source Type: research