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Total 83 results found since Jan 2013.

C2C12 myoblasts are more sensitive to the toxic effects of simvastatin than myotubes and show impaired proliferation and myotube formation
In conclusion, myoblasts were more susceptible to the toxic effects of simvastatin and simvastatin impaired myoblast proliferation and myotube formation. Impaired muscle regeneration may represent a new mechanism of statin myotoxicity.PMID:34111424 | DOI:10.1016/j.bcp.2021.114649
Source: Biochemical Pharmacology - June 10, 2021 Category: Drugs & Pharmacology Authors: Gerda M Sanvee Jamal Bouitbir Stephan Kr ähenbühl Source Type: research

P047  An unusual case of dermatomyositis with co-existent anti-GAD and anti-NXP2 antibody positivity
Conclusion GAD antibodies are known to be associated with many disorders including diabetes and stiff person syndrome and can recognise different epitopes in various diseases. This is the first documented case of GAD occurring in a DM patient, in the presence of NXP2 antibodies. IVIG is used to treat both s tiff man syndrome and refractory DM. It is possible that the combination of GAD and NXP2 contributed to the pathogenesis and severity of the clinical presentation in this case.Disclosure K. Beharry: None.G. Barminski: None.D. De Lord: None.
Source: Rheumatology - April 26, 2021 Category: Rheumatology Source Type: research

Patients with low IGF-I after curative surgery for Cushing's syndrome have an adverse long-term outcome of hypercortisolism-induced myopathy
CONCLUSION: Lower individual IGF-I concentrations six months after curative surgery for Cushing's syndrome are associated with adverse long-term myopathy outcome and IGF-I might be essential for muscle regeneration in the early phase after correction of hypercortisolism.PMID:33830940 | DOI:10.1530/EJE-20-1285
Source: European Journal of Endocrinology - April 8, 2021 Category: Endocrinology Authors: Frederick Vogel Leah Braun German Rubinstein Stephanie Zopp Sarina Benedix Holger Schneider Katrin Ritzel Katharina Schilbach Ralf Schmidmaier Felix Beuschlein Martin Bidlingmaier Martin Reincke Source Type: research

Endogenous glucose production in critical illness
Nutr Clin Pract. 2021 Mar 8. doi: 10.1002/ncp.10646. Online ahead of print.ABSTRACTRegulation of endogenous glucose production (EGP) by hormonal, neuronal, and metabolic signaling pathways contributes to the maintenance of euglycemia under normal physiologic conditions. EGP is defined by the generation of glucose from substrates through glycogenolysis and gluconeogenesis, usually in fasted states, for local and systemic use. Abnormal increases in EGP are noted in patients with diabetes mellitus type 2, and elevated EGP may also impact the pathogenesis of nonalcoholic fatty liver disease and congestive heart failure. In thi...
Source: Nutrition in Clinical Practice - March 8, 2021 Category: Nutrition Authors: Nameer Al-Yousif Sagar Rawal Michael Jurczak Hussain Mahmud Faraaz Ali Shah Source Type: research

GSE21961 cerebellum and hippocampus - deletor x wt
Contributors : Anu Wartiovaara ; Henna Tyynismaa ; Nuno RaimundoSeries Type : Expression profiling by arrayOrganism : Mus musculusProgressive mitochondrial respiratory chain (RC) deficiency is associated with a wide spectrum of adult-onset degenerative diseases, as well as with normal aging. We have previously generated the Deletor mice to model late-onset progressive RC defects. Here we report novel tissue-specific pathways contributing to mitochondrial disease pathogenesis, identified by gene expression analysis. We found that RC-deficient muscle fibers secrete the fasting-induced hormone, fibroblast growth factor 21 (FG...
Source: GEO: Gene Expression Omnibus - October 29, 2020 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

Updates in Feline Diabetes Mellitus and Hypersomatotropism
This article provides guidance on the use of flash glucose monitoring in cats and demonstrates how this technique can be used in a range of feline diabetic cases, including those where management is proving challenging. Other aspects of complicated feline diabetic care are also discussed, including management of the sick diabetic cat, potassium depletion myopathy, and treatment options for cats with hypersomatotropism-associated diabetes mellitus. The use of insulin glargine 300 U/ml as a promising new long-acting insulin for diabetic cats is also discussed.
Source: Veterinary Clinics of North America: Small Animal Practice - July 13, 2020 Category: Veterinary Research Authors: Linda Fleeman, Ruth Gostelow Source Type: research

Metabolic  alterations in spinal and bulbar muscular atrophy.
Metabolic alterations in spinal and bulbar muscular atrophy. Rev Neurol (Paris). 2020 Jul 03;: Authors: Francini-Pesenti F, Vitturi N, Tresso S, Sorarù G Abstract Spinal and bulbar muscular atrophy (SBMA) is a rare, X-linked neuromuscular disease characterised by lower motor neurons degeneration, slowly progressive myopathy and multisystem involvement. SBMA is caused by trinucleotide repeat expansion in the first exon of the androgen receptor (AR) gene on chromosome X that encodes a polyglutamine (polyQ) tract in the AR protein. Disease onset occurs between 30-60 years of age with easy fatigability, ...
Source: Revue Neurologique - July 9, 2020 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Do most patients with obesity or type 2 diabetes, and atrial fibrillation, also have undiagnosed heart failure? A critical conceptual framework for understanding mechanisms and improving diagnosis and treatment
AbstractObesity and diabetes can lead to heart failure with preserved ejection fraction (HFpEF), potentially because they both cause expansion and inflammation of epicardial adipose tissue and thus lead to microvascular dysfunction and fibrosis of the underlying left ventricle. The same process also causes an atrial myopathy, which is clinically evident as atrial fibrillation (AF); thus, AF may be the first manifestation of HFpEF. Many patients with apparently isolated AF have latent HFpEF or subsequently develop HFpEF. Most patients with obesity or diabetes who have AF and exercise intolerance have increased left atrial p...
Source: European Journal of Heart Failure - December 16, 2019 Category: Cardiology Authors: Milton Packer Tags: Review Source Type: research

Dynamic derangement in amino acid profile during and after a stroke-like episode in adult-onset mitochondrial disease: a case report
ConclusionsGrowth differentiation factor-15 can be used not only for the diagnosis of mitochondrial disease, but as an indicator of its acute exacerbation. A stroke-like episode of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes reflects a drastic derangement of multiple amino acids. The involvement of aspartic acid in the episodes should be explored in future studies.
Source: Journal of Medical Case Reports - October 20, 2019 Category: General Medicine Source Type: research