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Hemostatic Efficacy and Biocompatibility Evaluation of a Novel Absorbable Porous Starch Hemostat
CONCLUSION: According to our study, Ca2+CPSM could effectively achieve hemostasis in the standard rat liver injury model and exhibited good blood compatibility and in vivo tissue compatibility. These finding suggested that Ca2+CPSM as a new kind of APSH had its extensive clinical application value.PMID:34551638 | DOI:10.1177/15533506211046100
Source: Surgical Innovation - September 23, 2021 Category: Surgery Authors: Jianjun Zhu Zhuona Wu Wenzhong Sun Zhiyun Meng Xiaoxia Zhu Hui Gan Ruolan Gu Xuan Guo Guifang Dou Source Type: research

Fabrication of chitosan@calcium alginate microspheres with porous core and compact shell, and application as a quick traumatic hemostat
Publication date: Available online 24 June 2020Source: Carbohydrate PolymersAuthor(s): Xiaowei Wu, Zonghao Tang, Xiaoming Liao, Zhengchao Wang, Haiqing Liu
Source: Carbohydrate Polymers - June 27, 2020 Category: Biomedical Science Source Type: research

Thermal Treatment Stimulus on Erythrocyte Compatibility and Hemostatic Behaviour of One-Dimensional Bioactive Nano-Structures.
This study identifies the role and significance of heat treatment parameters on blood compatibility and hemostatic performances. Bioactive nanomaterials step-annealed at 550 °C and 600 °C enhances the biocompatibility due to the liberation of nitrate content. This also develops the anisotropic structures such as needle-like and rod-like appearances that positively improve the erythrocyte compatibility. Different stable crystalline phases such as NaCaPO4 , Na2 Ca2 Si3 O9 and Na1.8 Ca1.1 Si6 O14 were observed for all the bioactive materials, while in the case of 800 °C phase transition of Na3 CaPSiO7 was perceived along w...
Source: Biomed Res - May 2, 2020 Category: Research Authors: Chitra S, Bargavi P, Chandran RR, Balakumar S Tags: J Biomed Mater Res A Source Type: research

Hemostasis and Bone Regeneration Using Chitosan/Gelatin-BCP Bi-layer Composite Material
The aim of the study was to determine the hemostatic activity of a composite bi-layered topical hemostat composed of electrospun gelatin loaded with bi-phasic calcium phosphate and chitosan layer and its effect on bone formation. Morphology of the composite hemostat and its individual components were observed using scanning electron microscopy. In vitro biocompatibility of the topical hemostat tested using preosteoblasts cells (MC3t3-E1) showed no adverse toxicity. Confocal microscopy of seeded cells showed good cell adhesion while 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay indicated 15% incre...
Source: ASAIO Journal - July 30, 2019 Category: Medical Devices Tags: Tissue Engineering/ Biomaterials Source Type: research

Fabrication of porous starch microspheres by electrostatic spray and supercritical CO2 and its hemostatic performance.
Abstract Effective control of bleeding is critical to saving lives whether on the battle field or in civilian life. Microporous starch (MS) is a promising hemostat for its extensive sources, huge surface area and good biocompatibility. However, the hemostatic performance of MS is limited because of its complex preparation process and lack of effective component to activate coagulation factors. Herein, porous starch microspheres modified by calcium (Ca-PSM) with dense shell and honeycomb micro-porous core were prepared by electrostatic spray and supercritical CO2 for the first time. The topological morphology of Ca...
Source: International Journal of Biological Macromolecules - November 4, 2018 Category: Biochemistry Authors: Chen J, Chen S, Cheng W, Lin J, Hou S, Liu H, Chen Q Tags: Int J Biol Macromol Source Type: research

Influences of mesoporous zinc-calcium silicate on water absorption, degradability, antibacterial efficacy, hemostatic performances and cell viability to microporous starch based hemostat
In this study, mesoporous zinc-calcium silicate (m-ZCS) was synthesized, and microporous starch (MS) based hemostatic agents of m-ZCS/MS composites for hemorrhage control was fabricated. The results showed that the incorporation of m-ZCS into MS significantly enhanced the water absorption and degradability of the composites, which were dependent on the m-ZCS content. Moreover, the composites with antibacterial property could inhibit the growth of Escherichia coli (E. coli) and the antibacterial ratios increased with the m-ZCS content. The in vitro coagulation evaluation by using activated partial thromboplastin time (APTT)...
Source: Materials Science and Engineering: C - March 17, 2017 Category: Materials Science Source Type: research

Fibrin Glue Market: Asia is expected to witness high growth rates in the next five years, 2021
Fibrin glue is a unique adhesion material used in surgeries for closure of wounds. Fibrin glues are mainly extracted from collective plasma and contain different amounts of purified and virally-inactivated human proteins. Fibrin glue is composed of two components, including fibrinogen and factor XIII. These concentrated ingredients interact with a solution of thrombin and calcium to form coagulum. As the thrombin and fibrinogen/factor XIII solution combine, a clot of a blood protein called fibrin develops in a few seconds, depending on the dilute form of thrombin is used. Some of the characteristics of fibrin glue include ...
Source: Medical Hemostat - November 19, 2016 Category: Medical Equipment Authors: hemostatguy at gmail.com (hemostat guy) Source Type: blogs

Dabbling in Dentistry
Most people will experience dental pain or a dental complication at some point in their lives. Dental pain is an incredibly common complaint by people of all ages, especially those who lack dental insurance and suitable hygiene habits. Sometimes, though, poor dentition or injury is simply a result of bad luck. Patients often present to the ED hoping to find a dentist and an answer to their problems.   Your first thought? “I am not a dentist. What am I going to do?” You’re right to an extent. We are not dentists, and often feel we have little to offer patients for acute issues that require equipment we don’t have...
Source: The Procedural Pause - July 1, 2015 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs

Zeolite-based hemostat QuikClot releases calcium into blood and promotes blood coagulation in vitro.
Conclusion:Zeolite releases Ca(2+) into blood, thus accelerating the intrinsic pathway of blood coagulation and shortening the clot formation time. PMID: 23334236 [PubMed - as supplied by publisher]
Source: Acta Pharmacologica Sinica - January 21, 2013 Category: Drugs & Pharmacology Authors: Li J, Cao W, Lv XX, Jiang L, Li YJ, Li WZ, Chen SZ, Li XY Tags: Acta Pharmacol Sin Source Type: research