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Evaluation of Safety and Immunogenicity of a SARS-CoV-2(Severe Acute Respiratory Syndrome Coronavirus 2) Booster Vaccine (LEM-mR203)
Conditions:  COVID-19 Infection;  COVID-19 Vaccine Adverse Reaction Interventions:  Biological: LEM-mR203;  Biological: Placebo Sponsor:  Lemonex Not yet recruiting
Source: ClinicalTrials.gov - September 11, 2023 Category: Research Source Type: clinical trials
Covid Vaccines May Roll Out Within Days
The F.D.A. is expected to approve a new round of shots by Pfizer and Moderna as early as Monday to prepare Americans for the fall and winter season when infections usually tick upward.
Source: NYT Health - September 11, 2023 Category: Consumer Health News Authors: Christina Jewett Tags: Drugs (Pharmaceuticals) Vaccination and Immunization Coronavirus (2019-nCoV) Deaths (Fatalities) Influenza Elderly Health Insurance and Managed Care Respiratory Syncytial Virus (RSV) Coronavirus Omicron Variant Immune System BioNTech S Source Type: news
Heterologous DNA-prime/protein-boost immunization with a monomeric SARS-CoV-2 spike antigen redundantizes the trimeric receptor-binding domain structure to induce neutralizing antibodies in old mice
A multitude of alterations in the old immune system impair its functional integrity. Closely related, older individuals show, for example, a reduced responsiveness to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccines. However, systematic strategies to specifically improve the efficacy of vaccines in the old are missing or limited to simple approaches like increasing the antigen concentration or injection frequencies. We here asked whether the intrinsic, trimeric structure of the SARS-CoV-2 spike (S) antigen and/or a DNA- or protein-based antigen delivery platform affects priming of functional antibody r...
Source: Frontiers in Immunology - September 11, 2023 Category: Allergy & Immunology Source Type: research
Unleashing the power of shark variable single domains (VNARs): broadly neutralizing tools for combating SARS-CoV-2
The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) generated a joint global effort to develop vaccines and other treatments that could mitigate the negative effects and the rapid spread of the virus. Single-domain antibodies derived from various sources, including cartilaginous fish, camelids, and humans, have gained attention as promising therapeutic tools against coronavirus disease 2019. Shark-derived variable new antigen receptors (VNARs) have emerged as the smallest naturally occurring antigen-binding molecules. Here, we compile and review recent published studies on VNARs with the...
Source: Frontiers in Immunology - September 11, 2023 Category: Allergy & Immunology Source Type: research
DeSantis backs Florida surgeon general in urging residents against new Covid vaccines
Democrats say deaths will follow false claim by Dr Joseph Ladapo that new boosters were not tested on humansCovid-19 deaths are inevitable in Florida, Democrats are warning, after rightwing Republican governor Ron DeSantis joined the state ’s controversial surgeon general in urging residents to ignore public health advice and avoidnew vaccines targeting aresurgence of the virus.The extraordinary advice came at a feisty press conference in Jacksonville this week that was also marred by anunseemly shouting match between DeSantis, a candidate for his party ’s presidential nomination, and a Black Air Force veteran.Continue reading...
Source: Guardian Unlimited Science - September 9, 2023 Category: Science Authors: Richard Luscombe in Miami Tags: Florida US news Vaccines and immunisation Ron DeSantis Republicans Coronavirus Pfizer Science Health Infectious diseases Pharmaceuticals industry Source Type: news
Should I get a COVID-19 booster?
On 12 September, a vaccine advisory group to the Centers for Disease Control and Prevention (CDC) once again will wrestle with the question of who in the United States should receive a booster shot to protect against COVID-19.
As several new variants and an uptick in COVID-19 hospitalization fuel concerns among some health officials and the public, three companies have made new COVID-19 vaccines that can be used as a booster (or as primary doses for the unvaccinated). The Food and Drug Administration (FDA) is expected to approve at least one of these latest iterations before Tuesday’s meeting of CDC’s Advisory Com...
Source: Science of Aging Knowledge Environment - September 8, 2023 Category: Geriatrics Source Type: research
GPs begin early rollout of COVID-19 and flu jabs to care home patients
GP practices will start to deliver hundreds of thousands of flu and COVID-19 jabs to patients in care homes from today as this year's accelerated vaccination campaign gets underway.
Source: GP Online News - September 8, 2023 Category: Primary Care Tags: Coronavirus Source Type: news
Broad-Spectrum Antiviral Effect of Cannabidiol Against Enveloped and Nonenveloped Viruses
Conclusions: It was demonstrated that CBD inhibits structurally dissimilar viruses, suggesting that this phytochemical has broad-spectrum antiviral effect, representing a valuable alternative in emergency situations during viral outbreaks, like the one caused by severe acute respiratory syndrome coronavirus 2 in 2020.PMID:37682578 | DOI:10.1089/can.2023.0103
Source: Cell Research - September 8, 2023 Category: Cytology Authors: Agostina B Marquez Josefina Vicente Eliana Castro Daiana Vota Mar Ãa S RodrÃguez-Varela Priscila A Lanza Castronuovo Giselle M Fuentes Alejandro R Parise Leonardo Romorini Diego E Alvarez Carlos A Bueno Cristina L Ramirez Agustina Alaimo Cybele C Garc à Source Type: research
Why aren ’t we all being offered an autumn Covid booster? We can’t let cost prevent us keeping Britain healthy | Sheena Cruickshank
The UK ’s limited vaccine offer ignores the serious threat of long Covid – and the knock-on effects on the economyRecent headlines have been flagging thatCovid may be coming back, but, as weary as we all may be of this pesky virus, the truth is that it never really went away. Unlike viruses such as flu, there is no evidence that Covid has settled into a seasonal pattern. Its constant presence means that it has plenty of opportunity to gather new mutations that continue to make it worrisome.While we can limit the likelihood of exposure by enhancing ventilation orwearing masks, vaccination remains an important cornerston...
Source: Guardian Unlimited Science - September 8, 2023 Category: Science Authors: Sheena Cruickshank Tags: Vaccines and immunisation Coronavirus Health Infectious diseases NHS UK news Science Source Type: news
Sinopharm (HB02)-associated vaccine-induced immune thrombotic thrombocytopenia: a case report
ConclusionThis case highlights the possibility of vaccine-induced thrombotic thrombocytopenia occurrence by whole-virus coronavirus disease 2019 vaccines. Compared with vector-based vaccines, this phenomenon is rare for whole-virus vaccines. More studies on this type of vaccine regarding thrombotic thrombocytopenia should be considered.
Source: Journal of Medical Case Reports - September 8, 2023 Category: General Medicine Source Type: research
Management of coronavirus disease 2019 vaccine-induced cutaneous complications: A comprehensive literature review
J Family Community Med. 2023 Jul-Sep;30(3):161-170. doi: 10.4103/jfcm.jfcm_3_23. Epub 2023 Jul 24.ABSTRACTDespite the numerous reports of cutaneous manifestations associated with vaccines for coronavirus disease 2019 (COVID-19), the relationship between COVID-19 vaccines and cutaneous side effects remains unevaluated. In this review, we examine these manifestations and their management. Reported dermatoses included injection-site reaction (early and delayed), type I allergic reaction, morbilliform eruption, pityriasis rosea, Sweet syndrome, lichen planus, psoriasis, herpes zoster reactivation, erythema multiforme, Stevens-...
Source: Herpes - September 7, 2023 Category: Infectious Diseases Authors: Nouf F Bin Rubaian Abdullah A Aljalfan Serene R Almuhaidib Source Type: research
Stimuli-Responsive Hydrogel Microcapsules Harnessing the COVID-19 Immune Response for Cancer Therapeutics
We present the development of stimuli-responsive microcapsules, loaded with a viral immunogenetic agent, harnessing the immune response against the Coronavirus Disease 2019, COVID-19, to selectively attack liver cancer cells (hepatoma) or recognize breast cancer or hepatoma, by expression of green fluorescence protein, GFP. The pH-responsive microcapsules, modified with DNA-tetrahedra nanostructures, increased hepatoma permeation by 50%. Incorporation of a GFP-encoding lentivirus vector inside the tumor-targeting pH-stimulated miRNA-triggered and Alpha-fetoprotein-dictated microcapsules enables the demonstration of neoplas...
Source: Angewandte Chemie - September 7, 2023 Category: Chemistry Authors: Amit Fischer Avner Ehrlich Yevgeni Plotkin Yu Ouyang Klil Asulin Ioannidis Konstantinos Chunhai Fan Yaakov Nahmias Itamar Willner Source Type: research
Management of coronavirus disease 2019 vaccine-induced cutaneous complications: A comprehensive literature review
J Family Community Med. 2023 Jul-Sep;30(3):161-170. doi: 10.4103/jfcm.jfcm_3_23. Epub 2023 Jul 24.ABSTRACTDespite the numerous reports of cutaneous manifestations associated with vaccines for coronavirus disease 2019 (COVID-19), the relationship between COVID-19 vaccines and cutaneous side effects remains unevaluated. In this review, we examine these manifestations and their management. Reported dermatoses included injection-site reaction (early and delayed), type I allergic reaction, morbilliform eruption, pityriasis rosea, Sweet syndrome, lichen planus, psoriasis, herpes zoster reactivation, erythema multiforme, Stevens-...
Source: Herpes - September 7, 2023 Category: Infectious Diseases Authors: Nouf F Bin Rubaian Abdullah A Aljalfan Serene R Almuhaidib Source Type: research
