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Specialty: Biomedical Science

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Total 5325 results found since Jan 2013.

Metamaterial-Based Sensors Loaded Corona-Shaped Resonator for COVID-19 Detection by Using Microwave Techniques
AbstractThe paper proposes microwave-based metamaterial-based sensors for coronavirus infection detection. A sensor has been developed to calculate the electromagnetic wave ’s coefficients of transmission (S21) and reflection (S11) at resonance frequency. The computer simulation technology (CST) tools have been used to create the system and evaluate its consequences. The sensor uses electromagnetic interaction with a blood sample from a person who has COVID-19. This is done by watching for an alteration in the resonant frequency, which serves as a sign of COVID-19. Infectious people’s blood samples indicated a 740-MHz ...
Source: Plasmonics - August 30, 2023 Category: Biomedical Science Source Type: research

Non-1 < sup > st < /sup > seizure was less severe than 1 < sup > st < /sup > seizure with non-urgent level among suspected seizures transferred by ambulance
by Yotaro Asano, Ayataka Fujimoto, Keisuke Hatano, Keishiro Sato, Takahiro Atsumi, Hideo Enoki, Tohru Okanishi BackgroundTo prioritize emergency medical calls for ambulance transport for patients with suspected seizures, information about whether the event is their 1st or non-1st seizure is important. However, little is known about the difference between 1st and non-1st seizures in terms of severity. We hypothesized that patients transferred multiple times ( ≥2 times) would represent a milder scenario than patients on their first transfer. The purpose of this study was to compare patients with suspected seizures on 1st t...
Source: PLoS One - August 29, 2023 Category: Biomedical Science Authors: Yotaro Asano Source Type: research

Pulmonary embolism in COVID-19 pneumonia patients admitted to temporary hospital - The follow-up study
CONCLUSIONS: Ongoing SARS-CoV-2 infection along with massive involvement of lung tissue and concomitant thrombi in pulmonary arteries are challenging for physicians. It seems that simple D-dimer concentration assessment at admission may be a helpful tool not only to predict PE but also to estimate the long-term prognosis.PMID:37633116 | DOI:10.1016/j.advms.2023.08.002
Source: Advances in Medical Sciences - August 26, 2023 Category: Biomedical Science Authors: Tomasz Lewczuk Remigiusz Kazimierczyk Bozena Sobkowicz Anna Lisowska Source Type: research

Targeted drug delivery in pulmonary therapy based on adhesion and transmission of nanocarriers designed with a metal-organic framework
This study aimed to design a magnetic field-assisted targeted drug delivery system to the lungs using three types of metal-organic frameworks (MOFs) and nanoliposomes. The optimization of the system was based on three main parameters: the surface density of the nanocarriers' (NCs) adherence to each of the lung branches, the amount of drug transferred to each branch, and the toxicity based on the rate of nanocarrier delivery to the branches. The study investigated the effect of increasing the diameter of the drug carriers and the amount of drug loaded onto the NCs in improving drug delivery to targeted areas of the lung. Re...
Source: Biomechanics and Modeling in Mechanobiology - August 25, 2023 Category: Biomedical Science Authors: Hamed Ranjbar Amirhamzeh Farajollahi Mohsen Rostami Source Type: research

Regulation of coronavirus nsp15 cleavage specificity by RNA structure
In this study we investigate the role of RNA secondary structure in SARS-CoV-2 nsp15 endonuclease activity. Using a series ofin vitro endonuclease assays, we observed that thermodynamically stable RNA structures were protected from nsp15 cleavage relative to RNAs lacking stable structure. We leveraged the s2m RNA from the SARS-CoV-1 3 ’UTR as a model for our structural studies as it adopts a well-defined structure with several uridines, two of which are unpaired and thus highly probable targets for nsp15 cleavage. We found that SARS-CoV-2 nsp15 specifically cleaves s2m at the unpaired uridine within the GNRNA pentaloop o...
Source: PLoS One - August 24, 2023 Category: Biomedical Science Authors: Indraneel Salukhe Source Type: research

Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12
Sci Signal. 2023 Aug 22;16(799):eadg0485. doi: 10.1126/scisignal.adg0485. Epub 2023 Aug 22.ABSTRACTThe second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) evokes calcium ion (Ca2+) release from endosomes and lysosomes by activating two-pore channels (TPCs) on these organelles. Rather than directly binding to TPCs, NAADP associates with proteins that indirectly confer NAADP sensitivity to the TPC complex. We investigated whether and how the NAADP-binding proteins Jupiter microtubule-associated homolog 2 (JPT2) and like-Sm protein 12 (LSM12) contributed to NAADP-TPC-Ca2+ signaling in human cells. Biochemic...
Source: Science Signaling - August 22, 2023 Category: Biomedical Science Authors: Gihan S Gunaratne Eugen Brailoiu Sushil Kumar Yu Yuan James T Slama Timothy F Walseth Sandip Patel Jonathan S Marchant Source Type: research

Single-cell RNA sequencing and multiple bioinformatics methods to identify the immunity and ferroptosis related biomarkers of SARS-CoV-2 infections to ischemic stroke
CONCLUSION: We believe these genes (B4GALT5, CRISPLD2, F5, ACSL1, CREB5) may regulate the immune response and ferroptosis of multiple immune cells, mainly including monocytes, which may contribute to the development of COVID-19-related IS. In addition, these genes may be potential targets for the treatment of COVID-19-related IS.PMID:37606960 | DOI:10.18632/aging.204966
Source: Aging - August 22, 2023 Category: Biomedical Science Authors: Xiang Zhao Qingyu Liang Hao Li Zhitao Jing Dongmei Pei Source Type: research

Convergent activation of two-pore channels mediated by the NAADP-binding proteins JPT2 and LSM12
Sci Signal. 2023 Aug 22;16(799):eadg0485. doi: 10.1126/scisignal.adg0485. Epub 2023 Aug 22.ABSTRACTThe second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) evokes calcium ion (Ca2+) release from endosomes and lysosomes by activating two-pore channels (TPCs) on these organelles. Rather than directly binding to TPCs, NAADP associates with proteins that indirectly confer NAADP sensitivity to the TPC complex. We investigated whether and how the NAADP-binding proteins Jupiter microtubule-associated homolog 2 (JPT2) and like-Sm protein 12 (LSM12) contributed to NAADP-TPC-Ca2+ signaling in human cells. Biochemic...
Source: Science Signaling - August 22, 2023 Category: Biomedical Science Authors: Gihan S Gunaratne Eugen Brailoiu Sushil Kumar Yu Yuan James T Slama Timothy F Walseth Sandip Patel Jonathan S Marchant Source Type: research