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Total 5325 results found since Jan 2013.
Changes in hospitalizations and emergency department respiratory viral diagnosis trends before and during the COVID-19 pandemic in Ontario, Canada
In this study, we examined whether this reduction translated to reduced hospital admissions and emergency department (ED) visits associated with influenza, respiratory syncytial virus (RSV), human metapneumovirus, human parainfluenza virus, adenovirus, rhinovirus/enterovirus, and common cold coronavirus in Ontario. MethodsHospital admissions were identified from the Discharge Abstract Database and exclude elective surgical admissions and non-emergency medical admissions (January 2017-March 2022). Emergency department (ED) visits were identified from the National Ambulatory Care Reporting System. International Classificatio...
Source: PLoS One - June 16, 2023 Category: Biomedical Science Authors: Steven Habbous Source Type: research
Multivariate epidemic count time series model
by Shinsuke Koyama
An infectious disease spreads not only over a single population or community but also across multiple and heterogeneous communities. Moreover, its transmissibility varies over time because of various factors such as seasonality and epidemic control, which results in strongly nonstationary behavior . In conventional methods for assessing transmissibility trends or changes, univariate time-varying reproduction numbers are calculated without taking into account transmission across multiple communities. In this paper, we propose a multivariate-count time series model for epidemics. We also propos e a statis...
Source: PLoS One - June 16, 2023 Category: Biomedical Science Authors: Shinsuke Koyama Source Type: research
An allosteric inhibitor of sirtuin 2 deacetylase activity exhibits broad-spectrum antiviral activity
Most drugs used to treat viral disease target a virus-coded product. They inhibit a single virus or virus family, and the pathogen can readily evolve resistance. Host-targeted antivirals can overcome these limitations. The broad-spectrum activity achieved by host targeting can be especially useful in combating emerging viruses and for treatment of diseases caused by multiple viral pathogens, such as opportunistic agents in immunosuppressed patients. We have developed a family of compounds that modulate sirtuin 2, an NAD+-dependent deacylase, and now report the properties of a member of that family, FLS-359. Biochemical and...
Source: Journal of Clinical Investigation - June 15, 2023 Category: Biomedical Science Authors: Kathryn L. Roche, Stacy Remiszewski, Matthew J. Todd, John L. Kulp III, Liudi Tang, Alison V. Welsh, Ashley P. Barry, Chandrav De, William W. Reiley, Angela Wahl, J. Victor Garcia, Micah A. Luftig, Thomas Shenk, James R. Tonra, Eain A. Murphy, Lillian W. Source Type: research
Targeting patients for early COVID-19 therapy; Pre-infection metabolic dysfunction, polycystic ovary syndrome and risk of severe disease in patients under 65: A Massachusetts community-based observational study
by Susan R. Sama, Rebecca Gore, Ann Z. Bauer, Lawrence Garber, Richard Rosiello, Devi Sundaresan, Anne McDonald, David Kriebel
IntroductionThe demographics of those developing severe coronavirus disease (COVID-19) outcomes are shifting to younger patients. In an observational study utilizing electronic health records from a Massachusetts group medical practice, we identified 5025 patients with confirmed COVID-19 from March 1 to December 18, 2020. Of these, 3870 were under 65 years of age. We investigated the hypothesis that pre-infection metabolic or immunologic dysregulation including polycystic ovary syndrome (PCOS) incr...
Source: PLoS One - June 15, 2023 Category: Biomedical Science Authors: Susan R. Sama Source Type: research
Relationship between institutional ventilated COVID-19 case volume and in-hospital death: A multicenter cohort study
ConclusionsThere may be no significant relationship between institutional case volume and in-hospital mortality in patients with ventilated COVID-19.
Source: PLoS One - June 15, 2023 Category: Biomedical Science Authors: Shunsuke Amagasa Source Type: research
Two Years of Experience and Methodology of Korean COVID-19 Living Clinical Practice Guideline Development
CONCLUSION: We provided timely recommendations on living schemes and disseminated them to the public, policymakers and various stakeholders using webpages and social media. Although the output was successful, there were some limitations. The rigor of development issues, urgent timelines for public dissemination, education for new developers, and spread of several new COVID-19 variants have worked as barriers. Therefore, we must prepare systematic processes and funding for future pandemics.PMID:37309700 | PMC:PMC10261709 | DOI:10.3346/jkms.2023.38.e195
Source: Journal of Korean Medical Science - June 13, 2023 Category: Biomedical Science Authors: Miyoung Choi Hyeon-Jeong Lee Su-Yeon Yu Jimin Kim Jungeun Park Seungeun Ryoo Inho Kim Dong Ah Park Young Kyung Yoon Joon-Sung Joh Sunghoon Park Ki Wook Yun Chi-Hoon Choi Jae-Seok Kim Sue Shin Hyun Kim Kyungmin Huh In-Seok Jeong Soo-Han Choi Sung Ho Hwang Source Type: research
Effect of Wearing Personal Protective Equipment (PPE) for COVID-19 Treatment on Blood Culture Contamination: Implication for Optimal PPE Strategies
J Korean Med Sci. 2023 Jun 12;38(23):e180. doi: 10.3346/jkms.2023.38.e180.ABSTRACTThe personal protective equipment (PPE) used to minimize exposure to hazards can hinder healthcare workers from performing sophisticated procedures. We retrospectively reviewed 77,535 blood cultures (202,012 pairs) performed in 28,502 patients from January 2020 to April 2022. The contamination rate of all blood cultures was significantly elevated in the coronavirus disease 2019 ward at 4.68%, compared to intensive care units at 2.56%, emergency rooms at 1.13%, hematology wards at 1.08%, and general wards at 1.07% (All of P < 0.001). This f...
Source: Journal of Korean Medical Science - June 13, 2023 Category: Biomedical Science Authors: Jae Hyeon Park Taek Soo Kim Chan Mi Lee Chang Kyung Kang Wan Beom Park Nam Joong Kim Pyoeng Gyun Choe Myoung-Don Oh Source Type: research
Two Years of Experience and Methodology of Korean COVID-19 Living Clinical Practice Guideline Development
CONCLUSION: We provided timely recommendations on living schemes and disseminated them to the public, policymakers and various stakeholders using webpages and social media. Although the output was successful, there were some limitations. The rigor of development issues, urgent timelines for public dissemination, education for new developers, and spread of several new COVID-19 variants have worked as barriers. Therefore, we must prepare systematic processes and funding for future pandemics.PMID:37309700 | DOI:10.3346/jkms.2023.38.e195
Source: Journal of Korean Medical Science - June 13, 2023 Category: Biomedical Science Authors: Miyoung Choi Hyeon-Jeong Lee Su-Yeon Yu Jimin Kim Jungeun Park Seungeun Ryoo Inho Kim Dong Ah Park Young Kyung Yoon Joon-Sung Joh Sunghoon Park Ki Wook Yun Chi-Hoon Choi Jae-Seok Kim Sue Shin Hyun Kim Kyungmin Huh In-Seok Jeong Soo-Han Choi Sung Ho Hwang Source Type: research
Effect of Wearing Personal Protective Equipment (PPE) for COVID-19 Treatment on Blood Culture Contamination: Implication for Optimal PPE Strategies
J Korean Med Sci. 2023 Jun 12;38(23):e180. doi: 10.3346/jkms.2023.38.e180.ABSTRACTThe personal protective equipment (PPE) used to minimize exposure to hazards can hinder healthcare workers from performing sophisticated procedures. We retrospectively reviewed 77,535 blood cultures (202,012 pairs) performed in 28,502 patients from January 2020 to April 2022. The contamination rate of all blood cultures was significantly elevated in the coronavirus disease 2019 ward at 4.68%, compared to intensive care units at 2.56%, emergency rooms at 1.13%, hematology wards at 1.08%, and general wards at 1.07% (All of P < 0.001). This f...
Source: Journal of Korean Medical Science - June 13, 2023 Category: Biomedical Science Authors: Jae Hyeon Park Taek Soo Kim Chan Mi Lee Chang Kyung Kang Wan Beom Park Nam Joong Kim Pyoeng Gyun Choe Myoung-Don Oh Source Type: research
Two Years of Experience and Methodology of Korean COVID-19 Living Clinical Practice Guideline Development
CONCLUSION: We provided timely recommendations on living schemes and disseminated them to the public, policymakers and various stakeholders using webpages and social media. Although the output was successful, there were some limitations. The rigor of development issues, urgent timelines for public dissemination, education for new developers, and spread of several new COVID-19 variants have worked as barriers. Therefore, we must prepare systematic processes and funding for future pandemics.PMID:37309700 | DOI:10.3346/jkms.2023.38.e195
Source: Journal of Korean Medical Science - June 13, 2023 Category: Biomedical Science Authors: Miyoung Choi Hyeon-Jeong Lee Su-Yeon Yu Jimin Kim Jungeun Park Seungeun Ryoo Inho Kim Dong Ah Park Young Kyung Yoon Joon-Sung Joh Sunghoon Park Ki Wook Yun Chi-Hoon Choi Jae-Seok Kim Sue Shin Hyun Kim Kyungmin Huh In-Seok Jeong Soo-Han Choi Sung Ho Hwang Source Type: research
Effect of Wearing Personal Protective Equipment (PPE) for COVID-19 Treatment on Blood Culture Contamination: Implication for Optimal PPE Strategies
J Korean Med Sci. 2023 Jun 12;38(23):e180. doi: 10.3346/jkms.2023.38.e180.ABSTRACTThe personal protective equipment (PPE) used to minimize exposure to hazards can hinder healthcare workers from performing sophisticated procedures. We retrospectively reviewed 77,535 blood cultures (202,012 pairs) performed in 28,502 patients from January 2020 to April 2022. The contamination rate of all blood cultures was significantly elevated in the coronavirus disease 2019 ward at 4.68%, compared to intensive care units at 2.56%, emergency rooms at 1.13%, hematology wards at 1.08%, and general wards at 1.07% (All of P < 0.001). This f...
Source: Journal of Korean Medical Science - June 13, 2023 Category: Biomedical Science Authors: Jae Hyeon Park Taek Soo Kim Chan Mi Lee Chang Kyung Kang Wan Beom Park Nam Joong Kim Pyoeng Gyun Choe Myoung-Don Oh Source Type: research
Two Years of Experience and Methodology of Korean COVID-19 Living Clinical Practice Guideline Development
CONCLUSION: We provided timely recommendations on living schemes and disseminated them to the public, policymakers and various stakeholders using webpages and social media. Although the output was successful, there were some limitations. The rigor of development issues, urgent timelines for public dissemination, education for new developers, and spread of several new COVID-19 variants have worked as barriers. Therefore, we must prepare systematic processes and funding for future pandemics.PMID:37309700 | PMC:PMC10261709 | DOI:10.3346/jkms.2023.38.e195
Source: Journal of Korean Medical Science - June 13, 2023 Category: Biomedical Science Authors: Miyoung Choi Hyeon-Jeong Lee Su-Yeon Yu Jimin Kim Jungeun Park Seungeun Ryoo Inho Kim Dong Ah Park Young Kyung Yoon Joon-Sung Joh Sunghoon Park Ki Wook Yun Chi-Hoon Choi Jae-Seok Kim Sue Shin Hyun Kim Kyungmin Huh In-Seok Jeong Soo-Han Choi Sung Ho Hwang Source Type: research
Effect of Wearing Personal Protective Equipment (PPE) for COVID-19 Treatment on Blood Culture Contamination: Implication for Optimal PPE Strategies
J Korean Med Sci. 2023 Jun 12;38(23):e180. doi: 10.3346/jkms.2023.38.e180.ABSTRACTThe personal protective equipment (PPE) used to minimize exposure to hazards can hinder healthcare workers from performing sophisticated procedures. We retrospectively reviewed 77,535 blood cultures (202,012 pairs) performed in 28,502 patients from January 2020 to April 2022. The contamination rate of all blood cultures was significantly elevated in the coronavirus disease 2019 ward at 4.68%, compared to intensive care units at 2.56%, emergency rooms at 1.13%, hematology wards at 1.08%, and general wards at 1.07% (All of P < 0.001). This f...
Source: Journal of Korean Medical Science - June 13, 2023 Category: Biomedical Science Authors: Jae Hyeon Park Taek Soo Kim Chan Mi Lee Chang Kyung Kang Wan Beom Park Nam Joong Kim Pyoeng Gyun Choe Myoung-Don Oh Source Type: research
Two Years of Experience and Methodology of Korean COVID-19 Living Clinical Practice Guideline Development
CONCLUSION: We provided timely recommendations on living schemes and disseminated them to the public, policymakers and various stakeholders using webpages and social media. Although the output was successful, there were some limitations. The rigor of development issues, urgent timelines for public dissemination, education for new developers, and spread of several new COVID-19 variants have worked as barriers. Therefore, we must prepare systematic processes and funding for future pandemics.PMID:37309700 | DOI:10.3346/jkms.2023.38.e195
Source: Journal of Korean Medical Science - June 13, 2023 Category: Biomedical Science Authors: Miyoung Choi Hyeon-Jeong Lee Su-Yeon Yu Jimin Kim Jungeun Park Seungeun Ryoo Inho Kim Dong Ah Park Young Kyung Yoon Joon-Sung Joh Sunghoon Park Ki Wook Yun Chi-Hoon Choi Jae-Seok Kim Sue Shin Hyun Kim Kyungmin Huh In-Seok Jeong Soo-Han Choi Sung Ho Hwang Source Type: research
Effect of Wearing Personal Protective Equipment (PPE) for COVID-19 Treatment on Blood Culture Contamination: Implication for Optimal PPE Strategies
J Korean Med Sci. 2023 Jun 12;38(23):e180. doi: 10.3346/jkms.2023.38.e180.ABSTRACTThe personal protective equipment (PPE) used to minimize exposure to hazards can hinder healthcare workers from performing sophisticated procedures. We retrospectively reviewed 77,535 blood cultures (202,012 pairs) performed in 28,502 patients from January 2020 to April 2022. The contamination rate of all blood cultures was significantly elevated in the coronavirus disease 2019 ward at 4.68%, compared to intensive care units at 2.56%, emergency rooms at 1.13%, hematology wards at 1.08%, and general wards at 1.07% (All of P < 0.001). This f...
Source: Journal of Korean Medical Science - June 13, 2023 Category: Biomedical Science Authors: Jae Hyeon Park Taek Soo Kim Chan Mi Lee Chang Kyung Kang Wan Beom Park Nam Joong Kim Pyoeng Gyun Choe Myoung-Don Oh Source Type: research
