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Specialty: Biomedical Science
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Total 5325 results found since Jan 2013.
Broadening a SARS-CoV-1-neutralizing antibody for potent SARS-CoV-2 neutralization through directed evolution
Sci Signal. 2023 Aug 15;16(798):eabk3516. doi: 10.1126/scisignal.abk3516. Epub 2023 Aug 15.ABSTRACTThe emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) underscores the need for strategies to rapidly develop neutralizing monoclonal antibodies that can function as prophylactic and therapeutic agents and to help guide vaccine design. Here, we demonstrate that engineering approaches can be used to refocus an existing antibody that neutralizes one virus but not a related virus. Through a rapid affinity maturation strategy, we engineered CR3022, a SARS-CoV-1-neutralizing antibody, to bind to the receptor...
Source: Science Signaling - August 15, 2023 Category: Biomedical Science Authors: Fangzhu Zhao Meng Yuan Celina Keating Namir Shaabani Oliver Limbo Collin Joyce Jordan Woehl Shawn Barman Alison Burns Quoc Tran Xueyong Zhu Michael Ricciardi Linghang Peng Jessica Smith Deli Huang Bryan Briney Devin Sok David Nemazee John R Teijaro Ian A Source Type: research
A Model-Based Cost-Effectiveness Analysis of Long-Acting Monoclonal Antibody (Tixagevimab and Cilgavimab: Evusheld) Preventive Treatment for High-Risk Populations Against SARS-CoV-2 in Korea
CONCLUSION: As the COVID-19 variants and risk group-specific durable efficacy, toxicity (and/or resistance) and optimal dosing of Evusheld remain uncertain, better empirical estimates to inform these values in different epidemiological contexts are needed. These results may help decision-makers prioritize resources toward more equitable and effective COVID-19 control efforts.PMID:37582500 | PMC:PMC10427216 | DOI:10.3346/jkms.2023.38.e250
Source: Journal of Korean Medical Science - August 15, 2023 Category: Biomedical Science Authors: Youngji Jo Sun Bean Kim Jaehun Jung Source Type: research
COVID-19 Vaccination Status Among Korean Pediatric Population With Comorbidities
J Korean Med Sci. 2023 Aug 14;38(32):e248. doi: 10.3346/jkms.2023.38.e248.ABSTRACTThe pediatric population with comorbidities is a high-risk group for severe coronavirus disease 2019 (COVID-19). As of January 2023, the COVID-19 vaccination rate for at least two doses among Korean children 5-11 years is low at 1.1%. We summarized the COVID-19 vaccination status for the pediatric population (5-17 years) with comorbidities through July 2022 using the National Health Insurance Service database. Pediatric patients with comorbidities had higher vaccination rates than the general pediatric population (2.4% vs. 1.1% in 5-11-year-o...
Source: Journal of Korean Medical Science - August 15, 2023 Category: Biomedical Science Authors: Areum Shin Dong Wook Kim Young-Eun Kim Doo Ri Kim Jaehun Jung Yae-Jean Kim Source Type: research
Effects of COVID-19 and Influenza Vaccination on Rheumatic Diseases: Results From a Survey of Patient-Reported Outcomes After Vaccination
CONCLUSION: The results of the survey of patients with ARD revealed that patient-reported AEs and underlying disease flares after receiving the COVID-19 vaccine were significantly higher than those after the influenza vaccine.PMID:37582497 | PMC:PMC10427213 | DOI:10.3346/jkms.2023.38.e247
Source: Journal of Korean Medical Science - August 15, 2023 Category: Biomedical Science Authors: Ji-Won Kim Ju-Yang Jung Chang-Hee Suh Young-Min Ye Hyoun-Ah Kim Source Type: research
A Model-Based Cost-Effectiveness Analysis of Long-Acting Monoclonal Antibody (Tixagevimab and Cilgavimab: Evusheld) Preventive Treatment for High-Risk Populations Against SARS-CoV-2 in Korea
CONCLUSION: As the COVID-19 variants and risk group-specific durable efficacy, toxicity (and/or resistance) and optimal dosing of Evusheld remain uncertain, better empirical estimates to inform these values in different epidemiological contexts are needed. These results may help decision-makers prioritize resources toward more equitable and effective COVID-19 control efforts.PMID:37582500 | PMC:PMC10427216 | DOI:10.3346/jkms.2023.38.e250
Source: Journal of Korean Medical Science - August 15, 2023 Category: Biomedical Science Authors: Youngji Jo Sun Bean Kim Jaehun Jung Source Type: research
COVID-19 Vaccination Status Among Korean Pediatric Population With Comorbidities
J Korean Med Sci. 2023 Aug 14;38(32):e248. doi: 10.3346/jkms.2023.38.e248.ABSTRACTThe pediatric population with comorbidities is a high-risk group for severe coronavirus disease 2019 (COVID-19). As of January 2023, the COVID-19 vaccination rate for at least two doses among Korean children 5-11 years is low at 1.1%. We summarized the COVID-19 vaccination status for the pediatric population (5-17 years) with comorbidities through July 2022 using the National Health Insurance Service database. Pediatric patients with comorbidities had higher vaccination rates than the general pediatric population (2.4% vs. 1.1% in 5-11-year-o...
Source: Journal of Korean Medical Science - August 15, 2023 Category: Biomedical Science Authors: Areum Shin Dong Wook Kim Young-Eun Kim Doo Ri Kim Jaehun Jung Yae-Jean Kim Source Type: research
Effects of COVID-19 and Influenza Vaccination on Rheumatic Diseases: Results From a Survey of Patient-Reported Outcomes After Vaccination
CONCLUSION: The results of the survey of patients with ARD revealed that patient-reported AEs and underlying disease flares after receiving the COVID-19 vaccine were significantly higher than those after the influenza vaccine.PMID:37582497 | PMC:PMC10427213 | DOI:10.3346/jkms.2023.38.e247
Source: Journal of Korean Medical Science - August 15, 2023 Category: Biomedical Science Authors: Ji-Won Kim Ju-Yang Jung Chang-Hee Suh Young-Min Ye Hyoun-Ah Kim Source Type: research
A data-driven Markov process for infectious disease transmission
by Chengliang Wang, Sohaib Mustafa
The 2019 coronavirus pandemic exudes public health and socio-economic burden globally, raising an unprecedented concern for infectious diseases. Thus, describing the infectious disease transmission process to design effective intervention measures and restrict its spread is a critical scientific i ssue. We propose a level-dependent Markov model with infinite state space to characterize viral disorders like COVID-19. The levels and states in this model represent the stages of outbreak development and the possible number of infectious disease patients. The transfer of states between levels...
Source: PLoS One - August 10, 2023 Category: Biomedical Science Authors: Chengliang Wang Source Type: research
Numerical Investigation of Ag-Franckeite-Barium Titanium-BP-Based Highly Performed Surface Plasmon Resonance Sensor for Virus SARS-CoV-2 Detection
AbstractThe severe respiratory syndrome coronavirus-2 (SARS-CoV-2) is researching the COVID-19 pandemic epidemic as a worldwide health concern. Analytical tools that are sensitive, quick to produce results, affordable, and accurate with high precision are necessary to observe infected individuals for effective quarantine and prompt treatment. Therefore, this paper presents a numerical investigation of the Kretschmann configuration-based surface plasmon resonance (SPR) sensor, a label-free, highly sensitive, low-cost device for detecting SARS-CoV-2. The proposed sensor comprises of six layers, and is Bor Kron7 (BK7)-silver ...
Source: Plasmonics - August 8, 2023 Category: Biomedical Science Source Type: research
Impact of the COVID-19 Pandemic on Admission and Mortality Among Patients With Severe Emergency Diseases at Emergency Departments in Korea in 2020: Registry Data From the National Emergency Department Information System
J Korean Med Sci. 2023 Jul 31;38(30):e243. doi: 10.3346/jkms.2023.38.e243.ABSTRACTWe aimed to investigate the impact of the coronavirus disease 2019 (COVID-19) pandemic on admissions of patients with acute myocardial infarction, stroke, and severe trauma, and their excess mortality in emergency departments (EDs) in South Korea using registry data from the National Emergency Department Information System (NEDIS) for patients attending EDs of regional and local emergency medical centers. During the outbreak period of 2020, there were 350,698 ED visits, which was lower than the total in 2019 (392,627 visits). Multiple logisti...
Source: Journal of Korean Medical Science - August 1, 2023 Category: Biomedical Science Authors: Sun Kyoung Na Jeung-Hee Kim Weon-Young Lee Mi Ra Oh Source Type: research
Psychological and Personality Characteristics Associated With COVID-19 Vaccination Behavior in Korean General Population
CONCLUSIONS: People weighed the benefits of COVID-19 vaccination against the risk of side effects when deciding to receive the COVID-19 vaccine. Our findings also indicate that this vaccination behavior may be affected by coping mechanisms and psychological factors.PMID:37527911 | DOI:10.3346/jkms.2023.38.e234
Source: Journal of Korean Medical Science - August 1, 2023 Category: Biomedical Science Authors: Seunghyong Ryu Ju-Wan Kim Ju-Yeon Lee Young-Shin Kang Hee-Young Shin Sook-In Jung Jae-Min Kim Sung-Wan Kim Source Type: research
Change in Severity and Clinical Manifestation of MIS-C Over SARS-CoV-2 Variant Outbreaks in Korea
CONCLUSION: Omicron period were associated with less severe clinical manifestation compared to pre-delta and delta periods. Although incidence rate of MIS-C was lower for the omicron period than pre-delta and delta periods, number of patients reported with MIS-C may pose a substantial clinical burden.PMID:37527908 | DOI:10.3346/jkms.2023.38.e225
Source: Journal of Korean Medical Science - August 1, 2023 Category: Biomedical Science Authors: Young June Choe Eun Hwa Choi Jong Woon Choi Byung Wook Eun Lucy Youngmin Eun Yae-Jean Kim Yeo Hyang Kim Young A Kim Yun-Kyung Kim Ji Hee Kwak Hyukmin Lee June Dong Park Yeon Haw Jung Jin Gwack Sangwon Lee MIS-C Surveillance Group Source Type: research
