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Total 5394 results found since Jan 2013.

Increasing SARS-CoV-2 seroprevalence among UK pediatric patients on dialysis and kidney transplantation between January 2020 and August 2021
ConclusionsAnti-SARS-CoV-2 seroprevalence was low in 2020 and increased in early 2021. Serological surveillance complements nucleic acid detection and antigen testing to build a greater picture of the epidemiology of COVID-19 and is therefore important to guide public health responses.Graphical abstractA higher resolution version of the Graphical abstract is available asSupplementary information
Source: Pediatric Nephrology - September 22, 2023 Category: Urology & Nephrology Source Type: research

Viruses, Vol. 15, Pages 1952: Real-World Experience of the Comparative Effectiveness and Safety of Combination Therapy with Remdesivir and Monoclonal Antibodies versus Remdesivir Alone for Patients with Mild-to-Moderate COVID-19 and Immunosuppression: A Retrospective Single-Center Study in Aichi, Japan
Hiroshige Mikamo The coronavirus disease (COVID-19) pandemic continues to threaten global public health. Remdesivir and monoclonal antibodies have shown promise for COVID-19 treatment of patients who are immunocompromised, including those with cancer, transplant recipients, and those with autoimmune disorder. However, the effectiveness and safety of this combination therapy for patients who are immunosuppressed remain unclear. We compared the efficacy and safety of combination therapy and remdesivir monotherapy for patients with mild-to-moderate COVID-19 who were immunosuppressed. Eighty-six patients treated in July 2...
Source: Viruses - September 19, 2023 Category: Virology Authors: Jun Hirai Nobuaki Mori Daisuke Sakanashi Wataru Ohashi Yuichi Shibata Nobuhiro Asai Hideo Kato Mao Hagihara Hiroshige Mikamo Tags: Article Source Type: research

A pediatric case series of catastrophic gastrointestinal complications of posttransplant lymphoproliferative disease with increasing incidence, high association with coronavirus disease 2019, higher mortality, and a plea for early endoscopy to prevent late fatal outcome
ConclusionSince 80% of our patients had exposure to coronavirus, a potential relationship might be suggested between the two. Furthermore, as we witnessed in one case, urgent endoscopic investigation in immunocompromised patients presenting with gastrointestinal symptoms can improve the clinical outcomes and therefore should be considered for early diagnosis of posttransplant lymphoproliferative disorder.
Source: Journal of Medical Case Reports - September 19, 2023 Category: General Medicine Source Type: research

Pediatric cancer care management during the COVID-19 pandemic: a review of the literature and a single-centre real-life experience of an Italian pediatric oncology unit
In conclusion, we reported the real-life experience of our pediatric oncology unit during the pandemic period.EXPERT OPINION: Starting from the data available in literature, and our experience, showing the rarity of severe COVID-19 disease in pediatric patients with solid tumors, we recommend carefully tailoring all the oncological treatments (chemotherapy/targeted therapy/stem cell transplantation/radiotherapy). The aim is the preservation of the treatment's timing, balanced with an evaluation of possible severe COVID-19 disease.PMID:37712347 | DOI:10.1080/14737140.2023.2245148
Source: Expert Review of Anticancer Therapy - September 15, 2023 Category: Cancer & Oncology Authors: Olga Nigro Chiara Oltolini Federica Barzaghi Caterina Uberti Foppa Maria Pia Cicalese Maura Massimino Elisabetta Schiavello Source Type: research

Elevated tacrolimus levels among COVID-19 kidney transplant recipients are associated with worse disease severity and clinical outcomes
CONCLUSION: Elevated tacrolimus levels occur in many renal transplant recipients with moderate to severe COVID-19 and are associated with worse clinical outcomes. Close drug monitoring is crucial to avoid toxicities and minimize over-immunosuppression complications.PMID:37675489 | DOI:10.5414/CN111137
Source: Clinical Nephrology - September 7, 2023 Category: Urology & Nephrology Authors: Angelito Yango Bipin Bista Bernard Fischbach Shana Machado Alexandra Clark Sanna Khoja Nicole Dion Giovana Saracino Jessica Taylor Hoylan Fernandez Sathishkumar Seeliyur Duraiswamy Giuliano Testa Source Type: research