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Integrative landscape analysis of prognostic model biomarkers and immunogenomics of disulfidptosis-related genes in breast cancer based on LASSO and WGCNA analyses
CONCLUSION: The risk score model was effective for predicting both prognosis and sensitivity to therapeutic drugs, suggesting its possible usefulness for the management of patients with breast cancer.PMID:37736788 | DOI:10.1007/s00432-023-05372-z
Source: Clinical Breast Cancer - September 22, 2023 Category: Cancer & Oncology Authors: Shuyan Liu Yiwen Zheng Shujin Li Yaoqiang Du Xiaozhen Liu Hongchao Tang Xuli Meng Qinghui Zheng Source Type: research
The role of LOXL2 induced by glucose metabolism-activated NF- κB in maintaining drug resistance through EMT and cancer stemness in gemcitabine-resistant PDAC
J Mol Med (Berl). 2023 Sep 22. doi: 10.1007/s00109-023-02369-6. Online ahead of print.ABSTRACTGemcitabine is considered a standard treatment for pancreatic cancer, but developing drug resistance greatly limits the effectiveness of chemotherapy and increases the rate of recurrence. Lysyl oxide-like 2 (LOXL2) is highly expressed in pancreatic cancer and is involved in carcinogenesis and EMT regulation. However, studies on the role of LOXL2 in drug resistance are limited. Here, we investigated the mechanism of LOXL2 induction and the effect of LOXL2 on EMT and CSC in gemcitabine-resistant pancreatic cancer. Glucose metabolism...
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Yun Sun Lee Hyung Sun Kim Hyo Jung Kim Hyeon Woong Kang Da Eun Lee Myeong Jin Kim Woosol Chris Hong Ju Hyun Kim Minsoo Kim Jae-Ho Cheong Joon Seong Park Source Type: research
Duodenal-type follicular lymphoma in < sup > 18 < /sup > F-FDG PET/CT imaging: a case report
We report a case of a 36-year-old male patient with multiple, small, gray polypoid lesions in the descending duodenum which were detected by esophagogastroduodenoscopy. The pathological diagnosis was low-grade D-FL. 18F-FDG PET/CT was performed for staging and revealed the pancreas and peripheral lymph nodes were involved by FL, with a clinical IV stage. The patient underwent a bone marrow smear cytology, which revealed no bone marrow abnormalities, and excluded bone marrow involvement. He was treated with six cycles of chemotherapy using the R-CHOP regimen and reached complete remission.PMID:37736494 | PMC:PMC10509290
Source: Molecular Medicine - September 22, 2023 Category: Molecular Biology Authors: Wenpeng Huang Fangfang Chao Yushuo Peng Xiaoyue Zhang Qi Yang Lele Song Liming Li Lei Kang Source Type: research
Integrative landscape analysis of prognostic model biomarkers and immunogenomics of disulfidptosis-related genes in breast cancer based on LASSO and WGCNA analyses
CONCLUSION: The risk score model was effective for predicting both prognosis and sensitivity to therapeutic drugs, suggesting its possible usefulness for the management of patients with breast cancer.PMID:37736788 | DOI:10.1007/s00432-023-05372-z
Source: Clinical Genitourinary Cancer - September 22, 2023 Category: Cancer & Oncology Authors: Shuyan Liu Yiwen Zheng Shujin Li Yaoqiang Du Xiaozhen Liu Hongchao Tang Xuli Meng Qinghui Zheng Source Type: research
Taxane-Based Chemotherapy Is Effective in Metastatic Appendiceal Adenocarcinoma
Oncologist. 2023 Sep 20:oyad263. doi: 10.1093/oncolo/oyad263. Online ahead of print.ABSTRACTAppendiceal cancer is a rare, orphan disease with no therapies currently approved by the FDA for its treatment. Given the limited data regarding drug efficacy, these tumors have historically been treated with chemotherapy designed for colon cancer. However, an overwhelming body of molecular data has demonstrated that appendiceal adenocarcinoma is a distinct entity with key molecular differences from colon cancer, notably rare APC mutation. Recognizing that APC loss-of-function is thought to contribute to taxane resistance and that t...
Source: The Oncologist - September 22, 2023 Category: Cancer & Oncology Authors: Julia Dansby Aditya More Mohammad Zeineddine Abdelrahman Yousef Alisha Bent Farshid Dayyani Robert Wolff Michael Overman John Paul Shen Source Type: research
ctDNA-guided adjuvant treatment after radical-intent treatment of metastatic spread from colorectal cancer-the first interim results from the OPTIMISE study
CONCLUSION: The study was proven to be feasible and continues in the planned large-scale phase II trial. Results from the OPTIMISE study will potentially optimize the adjuvant treatment of patients undergoing radical-intent treatment of mCRC, thereby improving survival and reducing chemotherapy-related toxicity.PMID:37738268 | DOI:10.1080/0284186X.2023.2259083
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Louise Bach Callesen Torben Fr østrup Hansen Rikke Fredslund Andersen Niels Pallisgaard Stine Kramer Sven Schlander S øren Rafael Rafaelsen Anders Kindberg Boysen Lars Henrik Jensen Anders Jakobsen Karen-Lise Garm Spindler Source Type: research
Decentralizing cancer care in sub-Saharan Africa through an integrated regional cancer centre model: The case of Kenya
This study aimed to analyze the status of the utilization of services at regional cancer centers. We analyzed data from the district health information system, focusing on patient demographics, visit type, cancer stage, and the type of treatment provided. For comparison, a trend analysis of new cancer cases recorded at the main national referral hospital between 2011-2021 was also conducted. We conducted a descriptive analysis of the variables of interest; the median was used to summarize continuous variables and percentages were used for categorical variables. A total of 29,321 patients visited the regional centers in 202...
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Mary F Nyangasi Angela A McLigeyo David Kariuki Siwillis Mithe Albert Orwa Valerian Mwenda Source Type: research
The impact of intensified staging and combined therapies in locally advanced pancreatic cancer: a secondary analysis of prospective studies
CONCLUSIONS: The use of comprehensive pre-treatment staging, including laparoscopy and 18F-FDG-PET/CT scan, is an effective approach in identifying occult metastatic disease in LAPC patients. Our findings offer valuable insights into accurate staging and treatment efficacy, providing evidence-based support for optimal management strategies in LAPC patients.PMID:37737898 | DOI:10.1097/JS9.0000000000000755
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Michele Fiore Gian Marco Petrianni Pasquale Trecca Gabriele D'Ercole Alessandro Coppola Vincenzo La Vaccara Silvia Taralli Paola Cimini Carlo Greco Edy Ippolito Maria Lucia Calcagni Bruno Beomonte Zobel Damiano Caputo Roberto Coppola Sara Ramella Rolando Source Type: research
Correction to: A comparison of two techniques of postoperative analgesia: lignocaine-fentanyl intravenous infusion and ropivacaine-fentanyl epidural infusion in patients undergoing cytoreductive cancer surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC)-prospective randomized control study
Langenbecks Arch Surg. 2023 Sep 22;408(1):370. doi: 10.1007/s00423-023-03113-x.NO ABSTRACTPMID:37736776 | DOI:10.1007/s00423-023-03113-x
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Kiran Mahendru Rakesh Garg Sachidanand Jee Bharati Vinod Kumar Nishkarsh Gupta Seema Mishra Sushma Bhatnagar Mukurdipi Ray Suryanarayana Deo Source Type: research
Chemo-immune cell therapy by intratumoral injection of adoptive NK cells with capecitabine in gastric cancer xenograft model
CONCLUSION: Although NK cell therapy could effectively decrease the mitotic count in vivo, the obtained findings indicated lesser potency than MC despite ex vivo activation. In order to enhance NK cell therapy effectiveness, suppressive features of the tumor microenvironment and inhibitory immune checkpoints blockade should be considered.PMID:37736341 | PMC:PMC10509737 | DOI:10.34172/bi.2022.26386
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Zeinab Ghazvinian Shahrokh Abdolahi Mohammad Ahmadvand Amir Hossein Emami Samad Muhammadnejad Hamid Asadzadeh Aghdaei Jafar Ai Mohammad Reza Zali Iman Seyhoun Javad Verdi Kaveh Baghaei Source Type: research
Cytotoxicity of WT1-reactive T cells against Wilms tumor: An implication for antigen-specific adoptive immunotherapy
CONCLUSION: WT1-reactive T cells can be effectively enriched from the PBMCs of patients with Wilms tumor. Ex vivo generated WT1-reactive T cells might be considered an adoptive immunotherapeutic option for WT1+ Wilms tumors.PMID:37736339 | PMC:PMC10509739 | DOI:10.34172/bi.2023.27576
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Seyed Mostafa Monzavi Amir Ali Hamidieh Mohammad Vasei Jafar Ai Naser Ahmadbeigi Hamid Arshadi Samad Muhammadnejad Abdol-Mohammad Kajbafzadeh Source Type: research
Activity of pazopanib in < em > EWSR1-NFATC2 < /em > translocation-associated bone sarcoma
Oncoscience. 2023 Sep 20;10:44-53. doi: 10.18632/oncoscience.587. eCollection 2023.ABSTRACTPazopanib is a multi-kinase inhibitor that is currently approved for treatment of advanced renal cell carcinoma and chemotherapy-refractory soft tissue sarcoma. In this case report, we discuss the case of a patient with a EWSR1-NFATC2 fusion positive bone sarcoma who had exceptional tumor control through using pazopanib and surgery for an overall duration exceeding 5 years. We also review the literature on EWSR1-NFATC2 translocation-associated sarcomas and use of pazopanib in bone sarcomas.PMID:37736255 | PMC:PMC10511123 | DOI:10.18632/oncoscience.587
Source: Cancer Control - September 22, 2023 Category: Cancer & Oncology Authors: Mohamed A Gouda Maria A Zarzour Ara A Vaporciyan Kalevi Kairemo Hubert H Chuang Vivek Subbiah Source Type: research
Construction of an anoikis ‒related prognostic signature to predict immunotherapeutic response and prognosis in hepatocellular carcinoma
CONCLUSION: A successful anoikis-related prognostic signature and corresponding clinical nomogram were established, which might facilitate better predictions of prognosis and therapeutic responses for HCC patients.PMID:37736789 | DOI:10.1007/s00432-023-05428-0
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Chen Xiong Guoqiang Pan Hanchao Wang Guangxiao Meng Lunjie Yan Ruizhe Li Yuchuan Yan Yafei Yang Xiao Zhang Chuncheng Yang Zhaoru Dong Tao Li Source Type: research
Integrative landscape analysis of prognostic model biomarkers and immunogenomics of disulfidptosis-related genes in breast cancer based on LASSO and WGCNA analyses
CONCLUSION: The risk score model was effective for predicting both prognosis and sensitivity to therapeutic drugs, suggesting its possible usefulness for the management of patients with breast cancer.PMID:37736788 | DOI:10.1007/s00432-023-05372-z
Source: Cell Research - September 22, 2023 Category: Cytology Authors: Shuyan Liu Yiwen Zheng Shujin Li Yaoqiang Du Xiaozhen Liu Hongchao Tang Xuli Meng Qinghui Zheng Source Type: research
